Inhibitory Effects of Dryopteris erythrosora Extract on Tyrosinase Activity and Melanin Production in B16F10 Melanoma Cells

Skin color is determined by melanin distributed in the skin, hair, eye, heart, and brain. Melanin protects the skin against ultraviolet and scavenges the cellular reactive oxygen species. However, the abnormal accumulation of melanin induces hyperpigmentation diseases such as melisma, freckles, etc. Recent studies have focused on discovering plant-origin whitening agents against hyperpigmentation with fewer side effects and higher biocompatibility. Salt marsh plants have unique functional secondary metabolites that are not present in land plants due to their special habitat conditions comprising mixed inorganic salts and organic substances. Artemisia littoricola is a halophyte classified as belonging to the division Magnoliophyta, class Magnoliopsida, order Asterales, family Asteraceae, and genus Artemisia. It is expected that by cultivating and collecting this plant, large amounts of raw material can be procured for the cosmetic industry. This study examines the crude extract and solvent-fractionated extracts of A. littoricola (H2O, n-butanol, 85% aq. MeOH, and n-hexane) and evaluates the inhibition of melanogenesis in B16F10 murine melanoma cells. The crude extract and solvent fractions of A. littoricola inhibited the oxidation of tyrosine and L-DOPA in a concentration-dependent manner, indicating an inhibitory effect on melanin production. All extracts also inhibited the expression of proteins responsible for melanin synthesis, namely TRP-1 and TRP-2. Results of the current study reveal the anti-melanogenic properties of A. littoricola and indicate the potential application as a natural source of cosmeceutical agents with skin-whitening effects.

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Effect of Artemisia littoricola Extracts on Melanogenesis in Murine Melanoma Cells

Yang

Lee

Zhou

et al. 2023

JKFN

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Inhibitory Effects of Dryopteris erythrosora Extract on Tyrosinase Activity and Melanin Production in B16F10 Melanoma Cells

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Effect of Artemisia littoricola Extracts on Melanogenesis in Murine Melanoma Cells

Effect of Artemisia littoricola Extracts on Melanogenesis in Murine Melanoma Cells

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