Inhibitory Effects of Essential Oil Extracts From Panax Plants Against β-Secretase, Cholinesterase, and Amyloid Aggregation

Kawamoto, Hirokazu; Takeshita, Fumiaki; Murata, Kazuya

doi:10.1177/1934578x19881549

Cited by 8 publications

(10 citation statements)

References 25 publications

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“…Kayamoto et al [ 29 ] showed the ability of the fatty acid methyl linoleate to exert a selective activity against AChE with an IC 50 value of 68.8 μM, whereas a weak inhibitory activity was reported against BChE (IC 50 of 247.8 μM). Not active was methyl palmitate against both enzymes.…”

Section: Resultsmentioning

confidence: 99%

An Insight into Salvia haematodes L. (Lamiaceae) Bioactive Extracts Obtained by Traditional and Green Extraction Procedures

Tundis

Passalacqua

Bonesi

et al. 2022

Plants

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Even though Salvia is one of the most known genera of the Lamiaceae family, some traditionally used Salvia species are still now less investigated. To that end, the present study aims to evaluate the chemical profile and the potential bioactivities of extracts and related fractions obtained from the endemic sage Salvia haematodes L. by applying a traditional extraction method such as Soxhlet apparatus (SHS) and the rapid solid–liquid dynamic extraction (RSLDE) by Naviglio extractor® (SHN), considered among the “green techniques” operating at room temperature and with minimum solvent employment and minimum energy. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity was measured by a modified Ellman’s method. The antioxidant activity was investigated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing ability power (FRAP), and β-carotene bleaching tests. The SHN methanol fraction resulted the most active in all assays in particular in inhibiting lipid peroxidation with IC50 of 1.7 and 1.6 μg/mL, respectively, after 30 and 60 min of incubation. The SHN n-hexane fraction exhibited a selective activity against AChE with half-maximal inhibitory concentration (IC50) of 22.9 μg/mL, while the SHS n-hexane extract was more active against BChE (IC50 of 30.9 μg/mL). Based on these results, these fractions were subjected to further bio-fractionation by Medium Pressure Liquid Chromatography (MPLC) and the relative obtained fractions were investigated for their AChE and BChE inhibitory activity. A comparative analysis with bio-activity and chemical profile was performed. The observed biological effects provided us with a good starting point for further studies on S. haematodes extracts and fractions such as agents beneficial for the treatment of AD.

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Section: Resultsmentioning

confidence: 99%

An Insight into Salvia haematodes L. (Lamiaceae) Bioactive Extracts Obtained by Traditional and Green Extraction Procedures

Tundis

Passalacqua

Bonesi

et al. 2022

Plants

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“…Amyloid plaques also provoke the formation of neurofibrillary tangles of τ-protein, which along with Aβ plaques provoke the destruction of neuronal cells. Additionally, the formation of Aβ plaques leads to oxidative stress in the neurons, which accelerates the development of AD (Bui and Nguyen, 2017;Folch et al, 2016;Kawamoto et al, 2019;Kumar et al, 2015;Magalingam et al, 2018;Selkoe and Hardy, 2016).…”

Section: Description Symptoms and Pathophysiology Of Admentioning

confidence: 99%

“…The cholinergic hypothesis explains the pathophysiology of AD by a decrease of neurotransmitter ACh. It is proven that cognitive decline and memory loss are linked to the loss of cholinergic activity in the neocortex and hippocampus of AD patients brain (Bui and Nguyen, 2017;Damuka et al, 2020;Folch et al, 2016;Hampel et al, 2018;Kawamoto et al, 2019). AChE primarily degrades ACh in cholinergic synapses, while a closely related enzyme BChE has a role as a coregulator of cholinergic neurotransmission by hydrolyzing ACh.…”

Section: Description Symptoms and Pathophysiology Of Admentioning

confidence: 99%

“…Finally, a study claimed AD in older ages can be prevented if a subject took inhibitors of β-secretase and Aβ aggregation regularly from adolescence (Kawamoto et al, 2019).…”

Section: Current Therapeutic Strategies For Admentioning

confidence: 99%

“…and it is also found in other members of the Amaryllidaceae family, e.g. Narcissus and Leucojum species (Kawamoto et al, 2019;Thakur et al, 2019), while donepezil and rivastigmine are synthetic drugs. It has been reported that the aforementioned AChE inhibitors have numerous harmful effects including diarrhea, abdominal pain, skin rash, hepatotoxicity (Bui and Nguyen, 2017), which leads to the conclusion that there is an urgent need to search for new, efficient and safe AChE inhibitors.…”

Section: Current Therapeutic Strategies For Admentioning

confidence: 99%

See 2 more Smart Citations

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

Aradski-Alimpić¹,

Pavlović²,

Janković³

et al. 2021

Lekovite sirovine

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Considering the increase of the elderly population in recent years, the growing prevalence of age-related neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), has become one of the leading healthcare problems. Currently, available therapies for AD and PD are still limited, while medicinal plants used in traditional medicine for millennia can inhibit enzymes involved in the neurodegeneration processes in AD (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and PD (tyrosinase, TYR), hence their inhibiting effects are continuously being investigated especially in the past decade. This study was aimed to review data on medicinal plants as potential cholinesterases and TYR inhibitors reported from January 2018 until May 2021. The literature search was performed using several online bibliographical databases (Scopus, Web of Science, Science Direct, Google Scholar, PubMed, and ResearchGate) and two websites. Data analysis showed that the highest number of representatives belongs to Lamiaceae family (up to 20 %), followed by Asteraceae. Almost half of the tested samples were prepared from whole plant/aerial plant parts followed by leaves. The most frequently tested preparations were methanolic extracts (about 25 % of the samples examined). Additionally, synergistic interactions between different herbs and/or isolated compounds were considered as a promising strategy for further research. The presented data showed that medicinal plants preparations represent an unlimited source for research of new and more effective AD and PD treatments. This review will provide a useful starting point for further research on this topic.

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Chemical Composition, Antiaging Activities and Molecular Docking Studies of Essential Oils from Acca sellowiana (Feijoa)

El-Nashar

Adel

elshazly

et al. 2022

Chemistry & Biodiversity

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This study aimed to investigate the chemical composition of essential oils isolated from Acca sellowiana (feijoa) leaves and stems and elaborate on their relevance as natural anti-aging, coupled with molecular-docking studies. The isolated oils were analysed using gas chromatography-mass spectrometry analysis and investigated for inhibitory effects against acetylcholinesterase, β-secretase, collagenase, elastase and tyrosinase. Molecularmodelling study was performed using MOE-Dock program to evaluate binding interactions of major components with the above-mentioned targets. The leaf oil revealed the predominance of caryophyllene oxide (24.3 %), linalool (7.9 %), and spathulenol (6.6 %), while the stem oil was presented by caryophyllene oxide (38.1 %), αzingiberene (10.1 %) and humulene oxide II (6.0 %). The stem oil expressed superior inhibitory activities against acetylcholinesterase (IC 50 = 0.15 � 0.01 μg/mL), β-secretase (IC 50 = 3.99 � 0.23 μg/mL), collagenase (IC 50 = 408.10 � 20.80 μg/mL), elastase (IC 50 = 0.17 � 0.01 μg/mL) and tyrosinase (IC 50 = 8.45 � 0.40 μg/mL). The valuable binding interactions and docking scores were observed for caryophyllene oxide and α-zingiberene with acetylcholinesterase. Besides, α-zingibirene followed by linalool and τ-cadinol revealed tight fitting with collagenase and elastase. Additionally, linalool, spathulenol and τ-cadinol showed the best binding energy to tyrosinase. This study provides valuable scientific data on A. sellowiana as potential candidates for the development of natural antiaging formulations. The current study provided scientific evidence for the potential use of feijoa essential oils in antiaging formulations and as an adjuvant for the prophylaxis against Alzheimer disease.

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Inhibitory Effects of Essential Oil Extracts From Panax Plants Against β-Secretase, Cholinesterase, and Amyloid Aggregation

Cited by 8 publications

References 25 publications

An Insight into Salvia haematodes L. (Lamiaceae) Bioactive Extracts Obtained by Traditional and Green Extraction Procedures

An Insight into Salvia haematodes L. (Lamiaceae) Bioactive Extracts Obtained by Traditional and Green Extraction Procedures

Enzyme inhibitors as controllers of neurodegenerative diseases: An update of in vitro effects of medicinal plants

Chemical Composition, Antiaging Activities and Molecular Docking Studies of Essential Oils from Acca sellowiana (Feijoa)

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