Inhibitory Effects of Extracts from Peels of Citrus natsudaidai Encapsulated in Hybrid Liposomes on the Growth of Tumor Cells in Vitro

Kadota, Yutaka; Taniguchi, Chiho; Masuhara, Shigeo; Yamamoto, S.; Furusaki, Shintaro; Iwahara, M.; Goto, Kōichi; Matsumoto, Yōko; Ueoka, Ryuichi

doi:10.1248/bpb.27.1465

Cited by 6 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extracts of natsumikan from peels of Citrus natsudaidai were also incorporated in liposomes and evaluated against murine melanoma cells, with satisfactory results [192]. In general, all liposomal extracts showed improved inhibitory effects in relation to those of free extracts.…”

Section: Nanotechnology and Cancer Treatment—tackling Melanomamentioning

confidence: 99%

See 1 more Smart Citation

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

2019

View full text Add to dashboard Cite

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosinase. In addition, the role of nanotechnology as a valuable strategy to effectively deliver selective drugs is emphasized, either incorporating/encapsulating synthetic molecules or natural-derived compounds in lipid-based nanosystems such as liposomes. Nanoformulated compounds have been explored for their improved anticancer activity against melanoma and promising results have been obtained. Indeed, they displayed improved physicochemical properties and higher accumulation in tumoral tissues, which potentiated the efficacy of the compounds in pre-clinical experiments. Overall, these experiments opened new doors for the discovery and development of more effective drug formulations for melanoma treatment.

show abstract

Section: Nanotechnology and Cancer Treatment—tackling Melanomamentioning

confidence: 99%

“…The nanoformulated extract that displayed the most promising activity was that extracted with petroleum ether. For this reason, the liposome properties of Table 3 (C21) and the in vitro activity in Table 4 (F20) are related to this extract [192].…”

Section: Nanotechnology and Cancer Treatment—tackling Melanomamentioning

confidence: 99%