Inhibitory Effects of Extracts from Shochu Distillation Remnants on the Growth of Human Stomach Tumor Cells

Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway

“…We have previously reported that PSDR showed anticancer effects against various cancer cells in vitro (15,16). However, a comparative study on the anticancer effects of different PSDR has not been performed.…”

“…The result is shown in Fig. 2 (15,16). So, we investigated the induction of apoptosis in HepG2 and HuH-7 cells by barley-, rice-, and sweet potato-PSDR on the basis of fluorescence microscopic and flow cytometric analyses.…”

“…Furthermore, we have obtained valuable powder (PSDR) from SDR by the treatment with ethanol. In addition, rice-PSDR showed an effective growth inhibition of cancer cells along with the induction of apoptosis in vitro (15). Recently, we found that immunostimulatory effects of barley-PSDR on the serum interferon (IFN)-g production and natural killer (NK) activity without toxicity to normal rats in vivo (16).…”

Production of Antitumor Substances from Shochu Distillation Remnants

“…関する研究も行われている． 7,8) 最近，焼酎粕そのも のの培養がん細胞に対する抗腫瘍効果が報告され た． [9][10][11] 本研究では，微生物を利用して，バイオマ ス中に抗腫瘍性物質を生産させ，医薬品の開発に資 することを目的としている．上岡らは既に，リポ ソームのみによる in vitro での顕著ながん細胞増殖 抑制効果を， 12,13) また in vivo での担がんマウスの 延 命 効 果 [14][15][16] 及 び 臨 床 へ の 応 用 を 報 告 し て い る． 17,18) さらに，リポソームをドラッグデリバリー システムのキャリアーとして用い，in vitro での治 療効果を得ている． 19…”

Antitumor and Immunostimulatory Effects of Residual Powder from Barley-Shochu Distillation Remnants

“…8,9) Furthermore, the residual powder obtained from the freeze-dried supernatant of riceShochu distillation remnants had a more effective growth inhibition of human squamous carcinoma cells in vitro as well as inducing apoptosis and showed no toxicity to normal rats in vivo. 10) In this study, we examined how to produce useful powder (barley-powder) from the barley-Shochu distillation remnants and investigated both the effects of barley-powder on the growth inhibition of tumor cells in vitro and on the immunopotentiation of normal rats in vivo.…”