Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships

Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J

“…Though the literature suggests that the PDE4 inhibitory activity in Ginkgo extracts is associated with the flavanoids [6,21], we assayed both P8A and each of the ginkgolides for their ability to inhibit PDE4. There was a trace of activity in P8A and none in any of the individual ginkgolides (data not shown) suggesting that the effects studied here are independent of PDE4.…”

Phytochemistry of some Brazilian Plants with Aphrodisiac Activity

“…The flavonoids are widely distributed in gymnosperms and angiosperms with therapeutic potential because of their antioxidant, anti-inflammatory, hepatoprotective, cardio protective, antiulcer, anticancer, antimutagenic, antispasmodic, anti-allergic and antiviral activities, besides to show inhibit xanthine oxidase, protein kinase C and PDE (Rahimi et al, 2009;Ko et al, 2004). …”

“…Between a flavon and an isoflavone, it may be easier for isoflavones than flavones to bind to the moiety of PDE-5. The removal of the C-5 hydroxyl group promoted the loss of inhibition of PDE, proposing that the hydroxyl group is vital for PDE-5 inhibition (Ko et al, 2004).…”

Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin

“…Therefore, it is very significant for scientists to screen active compounds from plants and synthesized new derivatives with similar molecular structures as potential anti-tumor drugs or pro-drugs [1][2][3]. As a common active ingredient of many Chinese herbal medicines [4,5], flavonoids reveal little side effects in clinical research [6,7]. Among numerous flavonoids, isoliquiritigenin (ISL) attracted the attention of many scientists.…”