Inhibitory effects of herbal drugs on the growth of human ovarian cancer cell lines through the induction of apoptosis

Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma

“…26 siRNAtransfected cells (siPDPN, siNC, and mock) were plated at Cell Adhesion Assay For cell adhesion assay, siPDPN, siNC, and mock cells were plated at 200 cells per well on 96-well microplates in 100 ml of DMEM þ and incubated at 37 1C. At 30, 60, 90, and 120 min after plating, non-adherent cells were removed by gentle washing with PBS.…”

Chemopreventative Effect of Hochu-ekki-to (TJ-41) on Chemically Induced Biliary Carcinogenesis in Hamsters

“…We have obtained evidence that persistent cholangitis after bilioenterostomy in hamsters accelerates the development of biliary carcinoma through an increase in the proliferative activity of the biliary epithelium in accordance with the severity of cholangitis (9,10) and that etodolac, a selective COX-2 inhibitor, reduces both the occurrence of severe cholangitis and the acceleration of biliary epithelial cell kinetics after bilioenterostomy in hamsters, resulting in the prevention of BOP-induced biliary carcinogenesis (34). Recently, some studies have proved that TJ-41 reduced the development of several kinds of cancer (17)(18)(19)(20) and activities of inflammatory cytokines (35)(36)(37). …”

“…On the other hand, TJ-41 has recently been reported to activate macrophages and natural killer (NK) cells (13)(14)(15). Moreover, some studies have demonstrated that TJ-41 inhibits experimental liver metastasis (16) and also exerts an anti-neoplastic effect in several kinds of malignant tumors, including skin cancer, hepatoma, ovarian cancer, and uterine cancer (17)(18)(19)(20).…”

A Brief Review on the Experimental Aspects of Bojungikki-Tang in Cancer

“…Kao's group suggest that major compounds from BJIKT might act in a synergistic or additive pathway to inhibit Hep3B proliferation 17 . Zhu's group evaluated growth inhibition of 4 herbal medicine (Sho-saiko-to, Hochu-ekki-to, Juzen-taiho-to, and Ninjin-yoei-to) on six human ovarian cancer cells (KF-1, MN-1, A2780 and their respective cisplatinresistant sublines KF-r, MN-r, A2780cp) 18 . However, BJIKT even at high concentrations did not show growth inhibition and apoptosis on all six cancer cell lines 18 .…”

“…Zhu's group evaluated growth inhibition of 4 herbal medicine (Sho-saiko-to, Hochu-ekki-to, Juzen-taiho-to, and Ninjin-yoei-to) on six human ovarian cancer cells (KF-1, MN-1, A2780 and their respective cisplatinresistant sublines KF-r, MN-r, A2780cp) 18 . However, BJIKT even at high concentrations did not show growth inhibition and apoptosis on all six cancer cell lines 18 . Kuo's group investigated the anti-tumor effect of BJIKT, and two other herbal formulas in human gastric cancer MKN-74 cells 19 .…”