Inhibitory Effects of Kampo Medicine on Epstein-Barr Virus Antigen Induction by Tumor Promoter

Furukawa, Mitsuru; Sakashita, Hideo; Kamide, Michihiro; Umeda, Ryozo

doi:10.1016/s0385-8146(12)80021-6

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…This organ is firstly conceptualized as responsible for fluid balance, temperature, and fertility; and secondly, impacts the function of the heart, spleen, and liver, the latter being considered as the center of emotions [55,56]. For the determination of the appropriate herbal prescription, the physician investigates the complaints and symptoms of the patient, including taking their temperature, examining sensation, weakness, or sweating, symptoms which are not often primarily taken into account in conventional medicine [50,57]. To date nutraceuticals include: Dietary supplements (substances which have established nutritional functions able to affect structure and function of body such as vitamins, minerals, amino acids, fatty acids, probiotics, prebiotics, antioxidants, enzymes, coenzyme Q, carnitine, etc.…”

Section: Treatment Approachesmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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The menopausal transition, or perimenopause, is characterized by menstrual irregularities, vasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These changes can also affect the quality of life and one’s self-esteem. Hormone replacement therapy (HRT) is considered the best option to achieve therapeutic relief of different menopausal symptoms but is usually restricted to moderate or severe symptoms. Moreover, many women refuse HRT for a variety of reasons concerning the fear of cancer and other adverse effects. According to these considerations, new topics are emerging: Dissatisfaction with drug costs and conventional healthcare, desire for personalized medicines, and the public perception that “natural is good”. In this context, nonhormonal therapies are mostly evolving, and it is not unusual that women often request a “natural” approach for their symptoms. The aim of this study is to investigate nonhormonal therapies that have been identified to reduce the menopausal symptoms.

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Section: Treatment Approachesmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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“…SSHT has been shown to inhibit coxsackievirus B1 infection by inducing the expression of type I interferons 22 , 23 and has been reported to inhibit antigen production through chemical promoters against Epstein-Barr virus. 24 It has also been reported that SSHT could prevent hepatitis C virus (HCV) disease progression by promoting interleukin-10 and -12 production. 25 …”

Section: Resultsmentioning

confidence: 99%

“… 38 Another component of Scutellariae Radix, wogonin, also has an antiviral effect against the influenza virus 39 and HBV. 40 Lastly, Glycyrrhizae Radix et Rhizoma and its components have been reported to have antiviral activity against HCV, coxsackievirus B3, DHV, influenza, rotavirus, RSV, and herpes simplex virus 41 , 42 ( Table 2 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 51 ).…”

Section: Resultsmentioning

confidence: 99%

“… 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 Furthermore, the antiviral action of SSHT and its constituent herbs has been verified through various experimental studies. 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 Based on these results, it can be assumed that the therapeutic effect of QPT on COVID-19 is derived mainly from the antiviral effects of SSHT and that the synergistic effect of symptomatic treatment with the antiviral effects of other prescriptions contributes to the total effect of SSHT.…”

Section: Resultsmentioning

confidence: 99%

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Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: a narrative review

Kwon¹,

Lee²,

Jin³

et al. 2020

Integrative Medicine Research

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Background While the world struggles under the coronavirus disease 2019 (COVID-19) pandemic, a variety of antiviral agents and symptomatic treatments are being administered to patients and urgent clinical trials are underway. Under these circumstances, it is important to explore various possibilities for the treatment of COVID-19 including herbal medicines. Among various herbal medicines, Soshihotang (SSHT, Xiao Chai Hu Tang in Chinese) has been prescribed to treat various viral diseases and is used in combination with other herbal medicines depending on the patient’s symptoms. Methods For conducting the present review, we searched electronic databases focusing on the antiviral effect of SSHT in experimental and clinical study until April 2020. The search keywords included SSHT, constituents of SSHT, and antiviral effect. We also searched for materials related to topic directly from websites and published books. Based on these search results, we summarized the results of the included materials in the form of a narrative review. Results In a number of recent clinical studies, treatment with SSHT improved the infection status of the respiratory and hepatobiliary systems, and experimental studies demonstrated the antiviral effect of SSHT and its components. Furthermore, SSHT are being used in China—where COVID-19 outbreak first took place—and offer a new option to treat COVID-19. Conclusion Based on the present evidences, it is believed that SSHT is likely to be a new therapeutic option for COVID-19. Conducting further studies might provide improved understanding regarding the use of SSHT in treating COVID-19.

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“…This criterion excludes those situations that are out of the scope of kampo medicine. We also treated patients with kampo medicine and anti‐microbial agents as needed, according to reported favorable effects . Second, a single physician participated in this study, and the selection of kampo formula completely depended on his skill; therefore, objectivity was difficult to confirm.…”

Section: Discussionmentioning

confidence: 99%

Classification of acute phase febrile upper respiratory tract infection: Retrospective chart review

Yoshino

Takada

Horiba

et al. 2017

Traditional & Kampo Medicine

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Aim: Acute upper respiratory tract infections (URI) are a common problem in primary care settings. In traditional East Asian medicine, URI are categorized into three major disorders: influenza-like; common cold; and warmth disorders. The categorization of acute febrile URI, however, is yet to be ascertained. Here, we conducted a single-center retrospective chart review and classification of the various symptoms of acute phase febrile URI. Methods: A retrospective chart review between December 2013 and May 2015 was performed. We included febrile (≥38 C) patients with upper respiratory symptoms within 48 h from the onset of fever. Patient profile and symptoms were investigated at the first consultation and clusters were constructed based on symptoms. Results: The study included 135 patients. Patients were divided into two groups, day 1 and day 2, according to the time from fever onset. The incidence rate of symptoms, such as general fatigue and muscle pain, were higher in day 1 visitors. Local symptoms, including cough, sore throat, and nasal symptoms, were more frequent in day 2 visitors. Three clusters were observed: chills without sweating (60.0%); chills with sweating (23.0%); and without chills (17.0%). Conclusion: Symptoms in acute fever vary. The present three clusters observed suggest that the classical classification of febrile disease is still true. Further studies are necessary to confirm the course of febrile URI described in classical textbooks.

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Inhibitory Effects of Kampo Medicine on Epstein-Barr Virus Antigen Induction by Tumor Promoter

Cited by 6 publications

References 12 publications

A Nutraceutical Approach to Menopausal Complaints

A Nutraceutical Approach to Menopausal Complaints

Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: a narrative review

Classification of acute phase febrile upper respiratory tract infection: Retrospective chart review

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