Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract

Chittrakarn, Somsmorn; Sawangjaroen, Kitja; Prasettho, Supaporn; Janchawee, Benjamas; Keawpradub, Niwat

doi:10.1016/j.jep.2007.11.032

Cited by 66 publications

(55 citation statements)

References 10 publications

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“…Exceptions are the publications by Grewal, who observed seizures at very low doses [15], and by Reanmongkol et al, who observed convulsions at very high doses [31]. The same dosages did not result in toxicity in the experiments of other groups [1,29]. Interestingly, a discoloration of the skin and a hepatic face have been described in the literature [2,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Of the abovementioned alkaloids, mitragynine, corynantheidine, and 7-hydroxamitragynine are known to be pharmacologically active, but the other constituents might also provide a pharmacological effect. The opioid-like effects of analgesia [8] and reduced gastrointestinal motility [1,10] are attributed to mitragynine, which acts at μ-and δ-opioid receptors [8]. 7-Hydroxymitragynine shows a potent analgesic effect in rats even superior to morphine [11] and acts mainly at μ-opioid receptors and to a lesser extent at κ-opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

“…Mitragyna speciosa is an indigenous tree of Southeast Asia whose leaves have been utilized in Thailand and Malaysia over a long period of time as a drug to enhance the ability to work, as a narcotic, or as an alternative to opium [1,2]. M. speciosa is an illegal or controlled substance in several states (depending on the country either mitragynine, the plant itself, or its extracts are illegal), for example, Thailand, Australia, and Denmark [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa)

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa)

et al. 2011

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“…In folk medicine, it is often used to treat diarrhea. Methanolic extract of M. speciosa dose dependently inhibited castor oil-induced diarrhea and intestinal transit in rats (Chittrakarn et al, 2008).…”

Section: Plants Tested For Antidiarrheal Activity In Animal Models Ofmentioning

confidence: 92%

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Kota¹,

Teoh²,

Roufogalis³

2012

New Advances in the Basic and Clinical Gastroenterology

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“…The changes in body mass between the pre-and post-experiment were also determined. The percent inhibition of defecation score and fecal mass was calculated (16,17).…”

Section: Pharmacological Evaluationmentioning

confidence: 99%

Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives

Lakshmanan¹,

Mazumder²,

Sasmal³

et al. 2011

Acta Pharmaceutica

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Irritable bowel syndrome (IBS) is a disorder associated with muscarinic receptors (M 3 ) and characterized by cramping, abdominal pain, bloating, constipation and/or diarrhea (1, 2). Pain and intestinal spasms are the common state in chronic colon conditions such as irritable bowel syndrome, diverticulitis, and colitis. The muscarinic antagonistic activities, mediated by M 3 receptors, are responsible for the smooth muscle spasm (3, 4). Antispasmodics are the most commonly used drugs, of which antimuscarinic agents are an important class. However, the efficacy of these agents is significantly limited due to lack of receptor subtype selectivity, resulting in unacceptable atropine--like side effects.M 3 -selective antimuscarinic agents were sucessfully used in the treatment of IBS with minimal atropine-like side effects (5). A series of 1-substituted imidazoles 1a-d and 2a-d were synthesized and screened for antispasmodic and antidiarrheal activities. Antispasmodic activity was tested at various concentrations on isolated tissue preparations; concentration-response curves were plotted and compared with atropine. All compounds were found to inhibit contraction of the guinea pig ileum. Castor oil-induced diarrhea model in rats was used for evaluation of antidiarrheal activity. Parameters such as intestinal transit and volume of intestinal fluid were measured for antidiarrheal activity at 40 mg kg -1 dose and compared with the standard drug loperamide at 6 mg kg -1 dose. Defecation frequency in the test group was found to be significantly lower (p < 0.01) compared to the control group and comparable with that of the standard. The present study reveals that the compounds exert antidiarrheal activity through possible inhibition of intestinal movement and reduction of capillary permeability in the abdominal cavity.

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Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract

Cited by 66 publications

References 10 publications

Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa)

Intrahepatic Cholestasis Following Abuse of Powdered Kratom (Mitragyna speciosa)

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives

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