Inhibitory effects of Lemon balm (Melissa officinalis, L.) extract on the formation of advanced glycation end products

Miroliaei, Mehran; Khazaei, Sima; Moshkelgosha, Sorour; Shirvani, Mansoureh

doi:10.1016/j.foodchem.2011.04.039

Cited by 37 publications

(23 citation statements)

References 25 publications

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“…Based on the above experimental data, researchers concluded that the herb extract, possessing chaperone-like activity, would afford a protective effect against AGE-induced toxicity by suppression of receptor signaling pathways (e.g. RAGE antagonists) [48]. Also, Ma et al (2011) reported that rosmarinic acid, isolated from Salvia miltiorrhiza Bge, has a more potent inhibitory effect against the formation of AGEs in α-glucosidase (IC50 0.04 µM) than the positive control (AG with IC50 of 0.11 µM) [63].…”

Section: Cinnamic Acids and Derivativesmentioning

confidence: 99%

“…Thus, the daily consumption of dietary components, mainly from plant sources which have an antioxidant effect, is considered to be of potential benefit for prevention of diabetes and diabetic complications [47]. For example ethanol fractions of Melissa officinalis, L (Lemon balm) were shown to possess high inhibitory effect on the formation of advanced glycation end products in the late stage of the glycation process [48]. Green tea consumption (drinking) also significantly reduced the advanced glycation, the accumulation of AGEs and the cross-linking of tail tendon collagen in diabetes [49].…”

Section: Therapeutic Agentsmentioning

confidence: 99%

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Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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Section: Cinnamic Acids and Derivativesmentioning

confidence: 99%

Section: Therapeutic Agentsmentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…From chemical viewpoint, AGEs are formed by a three-step mechanism in which intense brown pigments appear at the early stage [27]. Since the generation of superoxide radicals is favored by transition metals at the glycoxidation phase of the Maillard reaction [31][32][33], established superoxide radical scavenging with metal chelating activity of balm extract are suggested in contributing to the observed inhibitory [12,23]. Similar metal chelating activity has been reported for guava leaf extract [34].…”

Section: Resultsmentioning

confidence: 71%

“…The extract of LB was prepared as previously described [23]. The LB leaves were air-dried and made into powder.…”

Section: Plant Extractionmentioning

confidence: 99%

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Protection against Advanced Glycation End Products and the Mode of Action of Lemon Balm on Hemoglobin Fructose-Mediated Glycation

Miroliaei¹,

Shafaei²,

Aminjafari³

et al. 2017

Med chem

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The present communication reports on changes in the secondary and tertiary structures of Hemoglobin (Hb) upon fructation. The presence of Lemon balm (LB) provided significant protection toward the formation of early (HbA1c) and advanced glycation end products (Hb-AGEs), as evident from circular dichroism (CD) and fluorescence studies. The degree of AGE modification and its inhibition were characterized with intrinsic fluorescence, the fibrillar state, and the exposure of hydrophobic clusters. An increased signal of intrinsic fluorescence was observed upon glycation, particularly in the later stage of fructation. Glycation mediated fibril formation and its inhibition were assessed by Thioflavin T (ThT) assay. These sequence of events were parallel with an increase in β-sheet content from ~2 to 13% for Hb-AGE, as evidenced by Congo red binding and CD. Furthermore, the late stage of glycation was also marked by an increase loss of heme moiety, confirming the relatively high affinity of ANS toward glycated-globin which was mitigated by applying the balm extract. However, the activity of balm can be attributed to inhibition of oxidative stress and free radicals derived from Hb-AGE, or chelation of metal ions producing in Fenton reaction. Overall, the presence of LB provided significant protection against AGE-induced deleterious processes, can qualify the herb as an effective AGE-inhibitor with potential prevention toward diabetic complications arising from Hb glycation.

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Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds

Afshari

Rahimmalek

Miroliaei

2018

Chemistry & Biodiversity

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A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC. In general, polyphenolic content follows the order of A. pachycephalla > A. nobilis > A. filipendulina > A. santolina > A. aucheri > A. millefolium. Most extracts exhibited marked anti-AGE ability in the bovine serum albumin (BSA)/methylglyoxal (MG) system, though A. pachycephala showed the highest potential. The formation of AGEs was assessed by monitoring the production of fluorescent products and circular dichroism (CD) spectroscopy. Diminution in free radical production (assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays) is discussed as potential mechanism for delay or reduced AGE. The results demonstrate the antiglycative, antioxidant and antimicrobial potential of Achillea species which can be attributed to polyphenols content and the effectiveness on generation of AGEs, thus Achillea species can be considered as natural sources for slowing down glycation related diseases.

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Inhibitory effects of Lemon balm (Melissa officinalis, L.) extract on the formation of advanced glycation end products

Cited by 37 publications

References 25 publications

Plant-Derived Agents with Anti-Glycation Activity

Plant-Derived Agents with Anti-Glycation Activity

Protection against Advanced Glycation End Products and the Mode of Action of Lemon Balm on Hemoglobin Fructose-Mediated Glycation

Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds

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