Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells

Seo, Won-Gil; Pae, Hyun‐Ock; Oh, Gi‐Su; Chai, Kyu Yun; Kwon, Tae-Oh; Yun, Young-Gab; Kim, Nayoung; Chung, Hun‐Taeg

doi:10.1016/s0378-8741(01)00221-5

Cited by 125 publications

(82 citation statements)

References 16 publications

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“…Recent studies of natural products with anti-inflammatory activity have been reported, and many of them had been done using macrophage-like cell lines, RAW264.7 cells 8,10,16,[26][27][28] and THP-1 cells. 11,13) However, we chose human colon carcinoma cells for screening because we were focusing on anti-inflammatory compounds in dietary products which might be effective through the mucosal immune response.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-has been identified as the major cytokine mediator in the expression of endotoxicity. 6) LPS-treated culture cells have been used to evaluate the anti-inflammatory effects of various materials, including folk medicines such as Polygonum tinctorium, 7) Cyperus rotundus, 8) Semecarpus anacardium, 9) Ginkgo biloba, 10) and Cryptolepis buchanani, 11) and natural foods such as turmeric, 12) ginger, 13) chicory, 14) and green tea. 15) Although the mechanisms of the anti-inflammatory effects of those materials are different, a wellknown mechanism has been described as inhibition of NF-B activation and NO production caused by antioxidant active compounds.…”

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confidence: 99%

“…15) Although the mechanisms of the anti-inflammatory effects of those materials are different, a wellknown mechanism has been described as inhibition of NF-B activation and NO production caused by antioxidant active compounds. 8,10,16) Buckwheat (Fagopyrum esculentum) is a health food in that it is rich in flavonoids such as rutin. 17) Rutin is an effective radical scavenger, 18) and Mukoda et al 19) have reported that buckwheat hull extract showed strong antioxidant activities in vitro and in vivo.…”

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confidence: 99%

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Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Ishii

Katsumura

Shiozuka

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Ishii

Katsumura

Shiozuka

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…Reactive oxygen species (ROS) are one of the most important factors that induce neuronal damage during ischemia/reperfusion (Sugawara and Chan, 2003). Damaging free radicals such as nitrogen oxide, superoxide, and peroxynitrite were shown to increase after IR (Seo et al, 2001). IR has also been found to be accompanied by reduced antioxidant capacity of brain and increased brain MDA level.…”

Section: Discussionmentioning

confidence: 96%

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

Setorki

Hooshmandi

2017

Bangladesh J Pharmacol

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Neuroprotective effect of Neuroprotective effect of Neuroprotective effect of Ziziphus Ziziphus Ziziphus spina spina spina---christi christi christi on brain injury inon brain injury inon brain injury induced by transient global cerebral duced by transient global cerebral duced by transient global cerebral ischemia and reperfusion in rat ischemia and reperfusion in rat ischemia and reperfusion in rat BJP IntroductionCerebral ischemia occurs when the blood supply to the brain is halted or reduced (Bhuiyan and Kim, 2010). Several factors such as thrombosis, embolism, and systemic hypoperfusion can lead to ischemia (Lakhan et al., 2009). Ischemia reduces the delivery of oxygen and nutrients to the cell which eventually leads to organ dys -function. A reduction of oxygen supply reduces cellular ATP. Required ATP is produced through anaerobic respiration. This leads to an accumulation of lactate, acidosis and finally cell death (Wells et al., 2010).The hippocampus, which plays important roles in learning, memory and emotion, is highly vulnerable to ischemic insults. Hypoxia in this region can lead to inhibition of synaptic potential which is a key mechanism to reduce energy consumption (Meilandt et al., 2004). I/R-induced generation of reactive oxygen species can cause oxidative damage to biomolecules such as lipids, proteins and DNA (Chan, 2001). Increased production of ROS during cerebral ischemia has been considered as a major factor in delayed neuro-nal cell death, especially in hippocampal CA1 pyrami-dal neurons (Hara and Mori, 2000). Anti-oxidant agents may be effective in the treatment of memory and learning deficits. Recently, natural anti-oxidants from plant materials have been reported to reduce neuronal damage caused by free radical (Pham-Huy et al., 2008).Sidr tree (Ziziphus spina-christi, Family Rhamnaceae) is an evergreen tree native to the South of Iran. It has pulpy edible fruits. Traditionally, its leaves are used to treat sores, pneumonia, dysentery, ulcer and as an antiseptics. The leaves contain phytosterols such as β-sitosterol, glycoside, flavonoids, saponins, tannins and lactone (Asgarpanah and Haghighat, 2012). Hydroalcoholic extract of Ziziphus spina-christi was found to be effective against scopolamine-induced anxiety in rats (Setorki, 2016). There is no previous study on the learning and memory-enhancing activities of Z. spina- AbstractThis study evaluated the protective effect of Ziziphus spina-christi on the cerebral oxidative stress and damage induced by ischemia. Male Wistar rats were divided randomly into six groups (seven in each group): Control group did not undergo surgery and received distilled water; shame group underwent surgery without ischemia; ischemic group underwent ischemia without any medication; extract-treated groups underwent ischemia and orally received 50, 100, 200 mg/kg/day doses Z. spina-christi extract. After behavioral tests, anti-oxidant capacity and malondialdehyde level of brain and serum were determined. Treatment of ischemic rats with extract significantly i...

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“…[53][54][55][56] Acorus calamus, 57) Asparagus racemosus, 58) Foeniculum vulgare, 40) Celastrus paniculatus, 19) Centella asiatica, 59) Crocus sativus, 60) Cyperus rotundus, 61) Elettaria cardamomum, 62) Phyllanthus emblica, 63) Glycyrrhiza glabra, 64) Nardostachys jatamansi, 65) Ocimum sanctus, 49) Piper longum, 66) Terminalia chebula, 67) Zingiber officinales 68) and Withania somnifera 69) are ingredients of polyherbal product Abana, have been reported to possess antioxidant property, which susceptible brain cells get exposed to less oxidative stress resulting in reduced brain damage and improved neuronal function.…”

Section: Discussionmentioning

confidence: 99%

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

Parle

Mani

2007

JOURNAL OF HEALTH SCIENCE

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The present study was aimed at investigating the effects of Abana, an Ayurvedic herbomineral preparation on memory and brain cholinesterase activity in mice. Drug Abana was administered orally in three doses (50, 100 and 200 mg/kg) for fifteen days to different groups of young and aged mice. Elevated plus maze and passive avoidance apparatus served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageinginduced amnesia served as the interoceptive behavioral models. Brain cholinesterase activity was also estimated. Abana (50, 100 and 200 mg/kg, orally (p.o.)) produced a dose-dependent improvement in memory scores of young and aged mice. Furthermore, it reversed the amnesia induced by scopolamine (0.4 mg/kg, intraperitoneally (i.p.)) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was reduced by Abana administered orally for 15 days. It may prove to be a useful remedy for the management of Alzheimer's disease.

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Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells

Cited by 125 publications

References 16 publications

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

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