Inhibitory Effects of Myagropsis myagroides Ethanol Extract on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice

Recently, the use of seaweed has attracted significant attention and has resulted in several seaweed-based studies for developing health-promoting foods. Sargassum sp. has been consumed as a part of the diet for centuries, especially in Asian countries, and has been reported to exhibit diverse biological effects, such as antioxidant, anti-obesity, and anti-inflammation effects. The present study involved the evaluation of the total phenolics content and in vitro antioxidant activities of seaweed using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) assays. Moreover, the inhibitory effect of lipid accumulation during the production of 3T3-L1 adipocytes and nitric oxide (NO) in RAW264.7 macrophages were investigated. The results revealed that Sargassum siliquastrum contained the highest total phenolics content (36.67 mg GAE/g of extract) and exhibited the highest antioxidant activity among the 19 Sargassum sp. seaweeds. In terms of the anti-adipogenic activity, the Sargassum nipponium and Sargassum siliquastrum extracts significantly inhibited lipid accumulation (up to 63%) compared to that of the control in 3T3-L1 cells. Additionally, the Sargassum sagamianum extract inhibited NO production (up to 85%) in lipopolysaccharide-induced RAW264.7 cells. Our results provide evidence that Sargassum sp. could be useful for the development of healthy functional foods.

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Inhibitory Activity of Sargassum hemiphyllum Ethanol Extract on Inflammatory Response in LPS-induced RAW 264.7 Cells and Mouse Model

Kim¹,

Kim²,

Park³

et al. 2017

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Inhibitory Effects of Myagropsis myagroides Ethanol Extract on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice

Cited by 3 publications

References 24 publications

Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides

Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides

Inhibition of nitric oxide and lipid accumulation by Sargassum sp. seaweeds and their antioxidant properties

Inhibitory Activity of Sargassum hemiphyllum Ethanol Extract on Inflammatory Response in LPS-induced RAW 264.7 Cells and Mouse Model

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