Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71

Choi, Hee Joung; Song, Hyuk‐Hwan; Lee, Jae-Sug; Ko, Hyun‐Jeong; Song, Jae-Hyoung

doi:10.4062/biomolther.2015.200

Cited by 24 publications

(19 citation statements)

References 28 publications

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“…Furthermore, these flavonoids were evaluated for their potential to inhibit viral attachment and entry. None of these flavonoids were found to be involved in the inhibition of attachment or entry of the virus in Vero cells [84].…”

Section: Flavonoids Isolated From Scutellaria Baicalensis Georgimentioning

confidence: 94%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

159

101

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Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.

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Section: Flavonoids Isolated From Scutellaria Baicalensis Georgimentioning

confidence: 94%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

159

101

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“…Ribavirin, a broad-spectrum nucleoside analogue, exhibited expected antiviral action. This antiviral drug was previously shown to have an inhibitory effect on many DNA and RNA viruses in cell culture 33 . However, ribavirin showed only a marginal effect on CVB3 infection of Vero cells.…”

Section: Discussionmentioning

confidence: 99%

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway

Song

Ahn

Kim

et al. 2019

Sci Rep

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Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for the prevention and treatment of CVB3 infection. We found that Saururus chinensis Baill extract showed critical antiviral activity against CVB3 infection in vitro . Further, manassantin B inhibited replication of CVB3 and suppressed CVB3 VP1 protein expression in vitro . Additionally, oral administration of manassantin B in mice attenuated CVB3 infection-associated symptoms by reducing systemic production of inflammatory cytokines and chemokines including TNF-α, IL-6, IFN-γ, CCL2, and CXCL-1. We found that the antiviral activity of manassantin B is associated with increased levels of mitochondrial ROS (mROS). Inhibition of mROS generation attenuated the antiviral activity of manassantin B in vitro . Interestingly, we found that manassantin B also induced cytosolic release of mitochondrial DNA based on cytochrome C oxidase DNA levels. We further confirmed that STING and IRF-3 expression and STING and TBK-1 phosphorylation were increased by manassantin B treatment in CVB3-infected cells. Collectively, these results suggest that manassantin B exerts antiviral activity against CVB3 through activation of the STING/TKB-1/IRF3 antiviral pathway and increased production of mROS.

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“…The antiviral activity was evaluated by the sulforhodamine (SRB) method based on the cytopathic effect (CPE) induced by viral infection, as previously reported [ 11 ]. One day before infection, 2 × 10 4 RD cells/well were seeded into a 96-well culture plate (Falcon; BD Biosciences, San Jose, CA, USA) and incubated at 37°C in an atmosphere of 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

Antiviral Activity of Itraconazole against Echovirus 30 InfectionIn Vitro

Lee

Choi

Song

et al. 2017

Osong Public Health Res Perspect

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ObjectivesEchovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30.MethodsThe cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known antiviral drugs, rupintrivir and pleconaril. The time course and time-of-addition assays were used to approximate the time at which itraconazole exerts its activity in the viral cycle.ResultsItraconazole and rupintrivir demonstrated the greatest potency against echovirus 30, demonstrating concentration-dependent activity, whereas pleconaril showed no antiviral activity. Itraconazole did not directly inactivate echovirus 30 particles or impede viral uptake into RD cells, but did affect the initial stages of echovirus 30 infection through interference with viral replication.ConclusionItraconazole can be considered a lead candidate for the development of antiviral drugs against echovirus 30 that may be used during the early stages of echovirus 30 replication.

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Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71

Cited by 24 publications

References 28 publications

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway

Antiviral Activity of Itraconazole against Echovirus 30 InfectionIn Vitro

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