Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses

Hong, Seung‐Heon; Yi, Jin-Mu; Kim, Hong-Jun; Choi, Ho‐Young; Kim, Yun-Kyung; Chae, Han-Jung; Kim, Hyung‐Ryong; Kim, Cheorl-Ho; Kim, Hyung-Min

doi:10.1016/j.jep.2005.02.006

Cited by 3 publications

(2 citation statements)

References 14 publications

(13 reference statements)

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“…The heterologous PCA reaction, a type I allergic inflammation, is associated with immediate hypersensitivity and an immune reaction resulting from the release of chemical mediators and cytokines (Hong et al, 2005). Mast cells are a key part of early allergic inflammation (Ezoe et al, 1981;Iuvone et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The mast cells were separated from macrophages and small lymphocytes using the Percoll discontinuous gradient centrifuge method, and the purity of rat peritoneal mast cells (RPMCs) was approximately 95% as assessed by o-toluidine blue staining (Hong et al, 2005). Purified RPMCs suspensions (10 4 cells per 1.8 ml of PBS) were pretreated with the test drug for 20 min at 37 o C, then stimulated by compound 48/80 (6 µg/mL) for 10 min at 37 o C. The released histamine from the RPMCs was separated by centrifugation, and the residual histamine in the RPMCs was collected by disrupting the cells with perchloric acid (Hong et al, 2005). Histamine content was measured by the OPA spectrofluorometric procedure of Shore et al (1959).…”

Section: Type I-iv Allergic Inflammationsmentioning

confidence: 99%

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Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammation and pro-inflammatory enzymes

Lee

Kim

2010

Arch. Pharm. Res.

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We previously reported that arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan isolated from Forsythia koreana, exhibits anti-inflammatory, antioxidant, and analgesic effects in animal models. In addition, arctigenin inhibited eosinophil peroxidase and activated myeloperoxidase in inflamed tissues. In this study, we tested the effects of arctigenin on type I-IV allergic inflammation and pro-inflammatory enzymes in vitro and in vivo. Arctigenin significantly inhibited the heterologous passive cutaneous anaphylaxis induced by ovalbumin in mice at 15 mg/kg, p.o., and compound 48/80-induced histamine release from rat peritoneal mast cells at 10 microM. Arctigenin (15 mg/kg, p.o.) significantly inhibited reversed cutaneous anaphylaxis. Further, arctigenin (15 mg/kg, p.o.) significantly inhibited the Arthus reaction to sheep's red blood cells, decreasing the hemolysis titer, the hemagglutination titer, and the plaque-forming cell number for SRBCs. In addition, arctigenin significantly inhibited delayed type hypersensitivity at 15 mg/kg, p.o. and the formation of rosette-forming cells at 45 mg/kg, p.o. Contact dermatitis induced by picrylchloride and dinitrofluorobenzene was significantly (p < 0.05) inhibited by surface treatment with arctigenin (0.3 mg/ear). Furthermore, arctigenin dose-dependently inhibited pro-inflammatory enzymes, such as cyclooxygenase-1 and 2, 5-lipoxygenase, phospholipase A2, and phosphodiesterase. Our results show that arctigenin significantly inhibited B- and T-cell mediated allergic inflammation as well as pro-inflammatory enzymes.

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Section: Discussionmentioning

confidence: 99%

Section: Type I-iv Allergic Inflammationsmentioning

confidence: 99%

Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammation and pro-inflammatory enzymes

Lee

Kim

2010

Arch. Pharm. Res.

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Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions

Jiang

Nakano

Yatsuzuka

et al. 2007

Biological & Pharmaceutical Bulletin

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Atopic dermatitis, allergic rhinitis, food allergy and asthma are classified as type I allergy. Atopic dermatitis is a common disorder in the population, and recent studies have shown that the disease is increasing, its prevalence increasing by 2-to 3-fold during the past three decades in industrialized countries, 1) and the reported prevalence among children up to the age of 16 ranges between 15% and 30% in Europe. 2)Atopic dermatitis is a condition manifesting eczema, serous papules, scaling and crust and in severe cases, erosion of the affected skin. Itching, a sensation causing the urge to scratch, is the most significant outcome of atopic dermatitis. This unpleasant sensation stimulates scratching of the lesioned skin, thus worsening the lesions.3) In the treatment of atopic dermatitis, anti-histamine and anti-allergy drugs are generally used, but they do not allay a severe itching sensation in atopic dermatitis. 4,5) Corticosteroid is also used as external medicine to relieve cutaneous pruritics, but it has many adverse effects including skin atrophy, rosacea, acne, purpura and so on 6) ; therefore, it is worth developing new treatment drugs besides the generally used medicines.Traditional Chinese medicines have a long history dating back several thousands of years. There are many herb medicines which have been applied to cutaneous disease and some traditional Chinese herbal medicines are prescribed for dermatitis.7) Among these, Moutan Cortex, the root bark of Paeonia suffruticosa ANDREWS, is a widely used drug for cutaneous disease in traditional Chinese medicine. 8,9) In association with this, Moutan Cortex is effective in cardiovascular and female genital disease. 10,11) In addition, Moutan Cortex has been described to show analgesic, sedative, antiinflammatory and antimicrobial properties 12) ; however, we have as yet very little information as to whether Moutan Cortex is effective in experimental allergy models.In the present study, therefore, we demonstrated the inhibitory effects of ethanol extract from Moutan Cortex on experimental immediate allergic reactions both in vitro and in vivo. MATERIALS AND METHODS AnimalsFemale ICR mice (6-10 weeks old) and male Wistar rats (7 weeks old) were obtained from Japan SLC, Inc., Shizuoka, Japan. The animals were housed in an airconditioned room maintained at 24Ϯ2°C with a relative humidity of 55Ϯ15%. They were given standard laboratory rodent food chow (Oriental Yeast, Tokyo) and water ad libitum. All procedures involving animals were conducted in accordance with the Guidelines for Animal Experiments at Okayama University Advanced Science Research Center. Chemicals and ReagentsThe following reagents were used in this study and their sources are shown in parentheses: histamine dihydrochloride (Sigma, St. Louis, MO, U.S.A.), compound 48/80 (Sigma) and Evans blue (Wako, Tokyo, Japan). Compound 48/80 and histamine were dissolved in physiological saline and administered intradermally. The drugs used were azelastine hydrochloride (Sigma), ketotifen fumarate (Sigma)...

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Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

Bezerra-Santos¹,

Pecanha²,

Piuvezam³

2005

Rev. bras. farmacogn.

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The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg/day for 5 days before and during OVA-sensitization strongly reduced the animal death and promoted reduction in total and OVA-specifi c serum IgE level. Spleen cells from AFL-treated sensitized animals showed a decreased proliferative background response when compared with non-sensitized animals. These results demonstrated that sub-acute intraperitoneal treatment with Cissampelos sympodialis extract has an anti-allergic effect.

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Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses

Cited by 3 publications

References 14 publications

Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammation and pro-inflammatory enzymes

Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammation and pro-inflammatory enzymes

Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions

Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

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