Inhibitory effects of Porphyra dentata extract on 3T3-L1 adipocyte differentiation

Choi, Su Mi; Lee, Su Yeon; Jang, Da hye; Lee, Suk Jun; Cho, Jeong-Yong; Kim, Sung-Hak

doi:10.5187/jast.2020.62.6.854

Cited by 8 publications

(6 citation statements)

References 47 publications

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“…Polysaccharides in seaweed have been identified as prebiotic fibers that can be fermented to produce short-chain fatty acids, which help prevent metabolic syndrome by changing the composition of the gut bacteriome and increasing the production of short-chain carboxylic acids [ 23 , 24 , 25 ]. Extracts of Porphyra dentata play a role in preventing obesity by exhibiting dual-generative inhibitory properties in 3T3-L1 cells [ 26 ]. In addition, the concentration of P. dentata extract was significantly associated with the suppression of obesity-induced gene expression in 3T3-L1 cells [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Extracts of Porphyra dentata play a role in preventing obesity by exhibiting dual-generative inhibitory properties in 3T3-L1 cells [ 26 ]. In addition, the concentration of P. dentata extract was significantly associated with the suppression of obesity-induced gene expression in 3T3-L1 cells [ 26 ]. Functional peptides—another component of seaweed—are known to inhibit the activity of angiotensin-converting enzymes, which lower blood glucose levels and blood pressure [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Seaweed Consumption with Metabolic Syndrome and Its Components: Findings from the Korean Genome and Epidemiology Study

Park

Lee

Shin

2022

Foods

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This study aimed to investigate the association between seaweed consumption and the odds of developing metabolic syndrome in middle-aged and elderly Koreans. The study included 5777 adults aged 40–69 years from 2001 to 2002 in the Ansan and Ansung cohorts of the Korean Genome and Epidemiology Study. Data on the consumption of seaweed, including laver and kelp/sea mustard, were obtained using a semiquantitative food frequency questionnaire. Multivariable logistic regression models were used to assess the association between seaweed consumption and the odds of developing metabolic syndrome and its components. Women in the highest tertile of laver consumption had lower odds of developing metabolic syndrome than those in the lowest tertile (adjusted odds ratio [AOR]: 0.70; 95% confidence interval [CI]: 0.54–0.92). Both men and women in the highest tertile of laver consumption had lower odds of abdominal obesity than those in the lowest tertile (AOR: 0.64, 95% CI: 0.42–0.98 for men; AOR: 0.53, 95% CI: 0.39–0.72 for women). These findings suggest that laver consumption is inversely associated with the odds of developing metabolic syndrome and abdominal obesity in Korean adults.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Seaweed Consumption with Metabolic Syndrome and Its Components: Findings from the Korean Genome and Epidemiology Study

Park

Lee

Shin

2022

Foods

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“…Besides, the other reason perhaps the feedback of the mature adipocytes, they synthesized and secreted the adiponectin thus weakened the ceRNA effect promotion for AdipoQ. After all, the AdipoQ expression pattern related with the adipogenesis, which was up-regulated with the increase of the differentiation period (34,35). Meanwhile, we co-transfected the 3'UTR and miR-144 inhibitor into pre-adipocyte then induced the pre-adipocyte adipogenesis.…”

Section: Discussionmentioning

confidence: 99%

MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FoxO1 protein complex

Lin

Wen

et al. 2021

Preprint

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Excessive adipogenesis caused obesity, which was a serious risk of health and led to a series of diseases, including type II diabetes (T2D) for example. Adipocyte as the basic unit of adipose tissue has emerged as one of significant target of the treatment of obesity-related metabolic syndromes by revealed its adipogenic molecular mechanism. MicroRNAs (miRNAs) have been demonstrated involving adipogenesis, and played a crucial role in the competitive endogenous RNA (ceRNA) effect. Besides that, C/EBPα as a crucial adipogenic regulator still lacked epigenetic explanation during pre-adipocyte adipogenesis. In this study, we first verified FoxO1 was one of the ceRNA of C/EBPα. They co-regulated adipogenesis through formed a protein complex that directly bound to its promoter to activate AdipoQ, and AdipoQ (Adiponectin) was a negative adipocytokines that suppressed adipogenesis, which played an important role in retaining adipogensis balance. Moreover, an adipose tissue specific enriched miRNA, miR-144 was the key regulator of the ceRNA effect between C/EBPα and FoxO1, which mediated the C/EBPα-FoxO1 complex formation, thus altered AdipoQ, furthermore regulated pre-adipocyte adipogenesis. This research will provide a new supplementary idea of the C/EBPα epigenetic role in pre-adipocyte adipogenesis.

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“…In response to the rising awareness of pet obesity and the associated dietary restrictions imposed by owners, manufacturers of pet probiotics have discerned the evolving needs of pet owners. This recognition has prompted a focus on developing products that align with the dietary requirements of obese pets, reflecting a growing market demand for specialized pet nutrition ( 6 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs

Kang,

Kwak,

Lee

et al. 2024

Microbiol Spectr

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Obesity and overweight among companion animals are significant concerns, paralleling the issues observed in human populations. Recent research has highlighted the potential benefits of various probiotics in addressing weight-related changes, obesity, and associated pathologies. In this study, we delved into the beneficial probiotic mechanisms in high-fat-induced obese canines, revealing that Enterococcus faecium IDCC 2102 (IDCC 2102) and Bifidobacterium lactis IDCC 4301 (IDCC 4301) have the capacity to mitigate the increase in body weight and lipid accumulation in obese canines subjected to a high-fat diet and hyperlipidemic Caenorhabditis elegans ( C. elegans ) strain VS29. Both IDCC 2102 and IDCC 4301 demonstrated the ability to reduce systemic inflammation and hormonal disruptions induced by obesity. Notably, these probiotics induced modifications in the microbiota by promoting lactic acid bacteria, including Lactobacillaceae , Ruminococcaceae , and S24-7 , with concomitant activation of pyruvate metabolism. IDCC 4301, through the generation of bacterial short-chain fatty acids and carboxylic acids, facilitated glycolysis and contributed to ATP synthesis. Meanwhile, IDCC 2102 produced bacterial metabolites such as acetic acid and butyric acid, exhibiting a particular ability to stimulate dopamine synthesis in a canine model. This stimulation led to the restoration of eating behavior and improvements in glucose and insulin tolerance. In summary, we propose novel probiotics for the treatment of obese animals based on the modifications induced by IDCC 2102 and IDCC 4301. These probiotics enhanced systemic energy utilization in response to high caloric intake, thereby preventing lipid accumulation and restoring stability to the fecal microbiota. Consequently, this intervention resulted in a reduction in systemic inflammation caused by the high-fat diet. IMPORTANCE Probiotic supplementation affected commensal bacterial proliferation, and administering probiotics increased glycolysis and activated pyruvate metabolism in the body, which is related to propanate metabolism as a result of pyruvate metabolism activation boosting bacterial fatty acid production via dopamine and carboxylic acid specialized pathways, hence contributing to increased ATP synthesis and energy metabolism activity.

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Inhibitory effects of Porphyra dentata extract on 3T3-L1 adipocyte differentiation

Cited by 8 publications

References 47 publications

Association of Seaweed Consumption with Metabolic Syndrome and Its Components: Findings from the Korean Genome and Epidemiology Study

Association of Seaweed Consumption with Metabolic Syndrome and Its Components: Findings from the Korean Genome and Epidemiology Study

MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FoxO1 protein complex

Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs

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