Inhibitory effects of resveratrol on orthodontic tooth movement and associated root resorption in rats

Liu, Xiaocan; Wang, Xuxia; Zhang, Lina; Yang, Fan; Nie, Fujiao; Zhang, Jun

doi:10.1016/j.archoralbio.2019.104642

Cited by 20 publications

(17 citation statements)

References 33 publications

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“…e rats were kept in transparent plastic cages at a constant temperature of 24-25 °C, 55% humidity, and 12 h light/12 h dark cycles for 1 week for the purpose of acclimation. e rats were fed soft food to minimize the risk of detachment of the orthodontic appliance after placement [16]. e orthodontic appliance was placed for all rats except for those in the negative control group, as described in previous studies [17,18].…”

Section: Animal Model and Study Groupsmentioning

confidence: 99%

Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Golshah

Omidi

Nikkerdar

et al. 2021

International Journal of Dentistry

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Introduction. Knowledge about the effects of medications, vitamins, and various supplements on orthodontic tooth movement (OTM) is imperative for orthodontists. This study aimed to assess the effect of methotrexate (MTX) injection on OTM in rats. Materials and Methods. Twenty-eight male Wistar rats were randomized into four groups (n = 7). The first molar and central incisor were connected using a nickel-titanium (NiTi) coil spring with a 50 g load in each rat. The two experimental groups received 0.75 mg/kg and 1.5 mg/kg MTX, respectively, intraperitoneally for 21 days. The negative control group did not receive any injection and did not undergo orthodontic treatment. The positive control group underwent orthodontic treatment and received 0.9% saline (NaCl) injections for 21 days. All rats were sacrificed with chloroform inhalation after 21 days; their maxilla was resected, and the mean number of Howship’s lacunae, blood vessels, osteoclasts, and resorption lacunae was counted. The reduction in bone volume (bone volume to total volume ratio (BV/TV)) at the site of the maxillary molar was quantified by microcomputed tomography (micro-CT). Results. OTM, the number of osteoclasts, and the number of blood vessels significantly increased in rats treated with MTX ( P < 0.05 ). However, the increase in the number of Howship’s lacunae and resorption lacunae was not significant ( P > 0.05 ). Lower BV/TV in the MTX groups was in agreement with the increased number of osteoclasts. Conclusion. Injection of MTX can significantly increase OTM and decrease root resorption in rats.

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Section: Animal Model and Study Groupsmentioning

confidence: 99%

Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Golshah

Omidi

Nikkerdar

et al. 2021

International Journal of Dentistry

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“…These movements could produce complications, such as root resorption. Liu et al [54] used two doses of resveratrol (5 mg/kg/day and 10 mg/kg/day) to evaluate its effect on the orthodontic tooth movement and root resorption. This study, performed on rats, demonstrated that resveratrol could inhibit tooth movement during orthodontic treatment and reduce the rate of root resorption during orthodontic therapy as described in (Figure 2).…”

Section: Remineralization Cell Viability and Differentiationmentioning

confidence: 99%

Polyphenols in Dental Applications

2020

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(1) Background: polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials. (2) Methods: the use of polyphenols to modify the surface properties of dental materials, mostly enamel and dentin, to afford them with better adhesion to resins and improved biological properties, such as antimicrobial activity, started more than 20 years ago, but no general overview has been written to our knowledge. (3) Results: the present review is aimed to show that molecules from all the major classes of polyphenolics allow for low coast improvements of dental materials and engineering of dental tissues.

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“…Trauma to the periodontal ligament can trigger external root resorption, so the correct handling of an avulsed tooth before replantation is of paramount importance 4 . External root resorption is a strictly local phenomenon and is more frequent in replanted teeth 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Replanted teeth have varying degrees of resorption, are generally asymptomatic and are often not diagnosed 4 . These complications are related to the involvement of the healing of the pulp and the periodontal ligament 3 .…”

Section: Introductionmentioning

confidence: 99%

Mediators involved in tooth resorption following delayed replantation: an experimental study

Silva

Longo

Oliveira

et al. 2021

Preprint

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Inflammatory and replacement tooth resorption are common outcomes following tooth replantation, biological mediators involved in these processes are widely unknown. The aim study was to investigate molecules involved in tooth resorption following permanent tooth avulsion and delayed replantation. Dog premolars were extracted and kept dry for 20, 60 and 90 minutes (n= 30). The teeth were replanted, splinted. After 120 days, the animals were euthanized and tissues were removed for histological processing. Slides were stained for microscopic analysis, submitted to tartrate resistant acid phosphatase (TRAP) histoenzymology and immunostained for RANK, RANKL, OPG, alkaline phosphatase and periostin. Data obtained were submitted to statistical analysis using the chi-square, Fisher and one-way ANOVA tests (alpha= 0.05). In inflammatory resorption areas, TRAP + and RANK + osteoclasts surrounding the replanted teeth were identified, regardless of the extra-alveolar time. RANKL synthesis in this region was higher in longer extra-alveolar times and was more intense after keeping the tooth dry for 90 minutes compared to other periods. In the replacement reabsorption area, there was lower synthesis of periostin and higher alkaline phosphatase production. Inflammatory resorption was characterized by osteoclast recruitment and RANKL synthesis and replacement resorption was characterized by inhibition of periostin and alkaline phosphatase syntheses.

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Inhibitory effects of resveratrol on orthodontic tooth movement and associated root resorption in rats

Cited by 20 publications

References 33 publications

Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Effect of Methotrexate Injection on Orthodontic Tooth Movement: An Experimental Study on Rats

Polyphenols in Dental Applications

Mediators involved in tooth resorption following delayed replantation: an experimental study

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