Inhibitory effects of sesquiterpene lactones on the aggregation and cytotoxicity of prion neuropeptide

Modulating the aggregation of human prion protein PrP106–126 by an indole-based cyclometallated palladium complex

“…The PrP 106–126 peptides mature into insoluble clumps or fibrils after prolonged incubation at 37 °C. 63 However, in the presence of an inhibitor molecule, the production of fibrils is significantly reduced. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) are well-known methods for closely inspecting the external morphological characteristics of insoluble fibrils.…”

β‐Carboline Alkaloids Resist the Aggregation and Cytotoxicity of Human Islet Amyloid Polypeptide

“…The solution environment did not interfere with the normal growth of the peptide. [71,72] For the inhibition experiments, β-carboline was added into the peptide solution for co-incubation, and the final concentration of hIAPP was 5 μM. After incubation at 310 K for 72 h, the samples were dropped onto clean silicon wafers, dried and tested by AFM.…”