Inhibitory Effects of Sildenafil Citrate on the Tonus of Isolated Dog Internal Anal Sphincter

Aygen, Erhan; Camcı, Celaletdin; Durmus, Ali Sait; Doğru, Osman; Topuz, Ömer; Ayten, Refik; Ayar, Ahmet

doi:10.1007/s10350-005-0064-2

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…Anal tone was reduced by an average of 18% in less than 3 minutes. These findings have been corroborated in in vitro studies [176,177]. Currently there is no published work on whether phosphodiesterase-5 inhibitors can induce healing of fissures but this topic warrants further investigation.…”

Section: Phosphodiesterase-5 Inhibitorssupporting

confidence: 66%

A review of chronic anal fissure management

Collins

Lund

2007

Tech Coloproctol

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Anal fissure management has rapidly progressed in the last 15 years as our understanding of fissure pathophysiology has developed. All methods of treatment aim to reduce the anal sphincter spasm associated with chronic anal fissures. Surgical techniques have been used for over 100 years with success. Lateral internal sphincterotomy remains the surgical treatment of choice for many practitioners. Postoperative impairment of continence remains controversial. Recently, less invasive methods of treatment have been explored. Topical nitrates, calcium channel blockers and botulinum toxin are established treatments. These and other non-surgical treatments are described in this review. Various guidelines and treatment algorithms for anal fissure are also discussed.

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Section: Phosphodiesterase-5 Inhibitorssupporting

confidence: 66%

A review of chronic anal fissure management

Collins

Lund

2007

Tech Coloproctol

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“…There are some trials focusing on new areas of use sildenafil, including chronic anal fissure [16,17], primary pulmonary hypertension [18], the increasing of retinal blood flow [19], and hypercontractile eosophageal motility disorders [20]. Eherer et al [21] reported that sildenafil reduced basal pressure and sphincter volume of the lower oesophageal sphincter.…”

Section: Discussionmentioning

confidence: 98%

Effect of sildenafil on wound healing: an experimental study

Derıcı¹,

Kamer²,

Ünalp³

et al. 2009

Langenbecks Arch Surg

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“…Aygen et al. [75] showed that sildenafil relaxes acetylcholine stimulated contractions of isolated dog IAS. Torrabadella et al.…”

Section: Gastrointestinal Implicationsmentioning

confidence: 99%

“…Ballester et al [74] investigated the relaxant effects of sildenafil on isolated human IAS concluding that it relaxes the augmented tone of human IAS in vitro supporting its potential use in treating chronic anal fissure. Aygen et al [75] showed that sildenafil relaxes acetylcholine stimulated contractions of isolated dog IAS. Torrabadella et al [76] showed that topical 10% sildenafil was accompanied by significant reduction in anal sphincter pressure with average onset of action <3 minutes with maximum effect 1 minute later.…”

Section: Anal Fissurementioning

confidence: 99%

Oral Phosphodiesterase Type 5 Inhibitors: Nonerectogenic Beneficial Uses

Mostafa

2008

The Journal of Sexual Medicine

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Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate monophosphate (cGMP) specifically to 5′ GMP. PDE5 inhibitors were a breakthrough medication that addressed a previously unfulfilled medical need. They promoted vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation. Sildenafil, vardenafil, and tadalafil were approved then introduced as effective treatments for male erectile dysfunction. This impact has stimulated academic, clinical, and industrial research. Aim To highlight the nonerectogenic beneficial uses of oral PDE5 inhibitors. Method A systematic review of published studies in this affair based on a Pubmed and medical subject heading databases search of all concerned articles. Main Outcome Measures Demonstrated beneficial as well as applicable uses of oral PDE5 inhibitors. Results As chemical molecules, these drugs were shown to exert potential nonerectogenic beneficial effects. They showed efficacy as a useful adjunct in the management of pulmonary hypertension. Additional uses were extended to different utilities: essential hypertension, benign prostatic hyperplasia, gastrointestinal disorders, endothelial dysfunction, female sexual dysfunction, genital blood flow, exercise capacity, Raynaud's phenomenon, sperm motility, etc. Conclusion Exploring PDE5 inhibitors for their possible medical applications in diverse specialties seems to be beneficial in making use of these molecules for the welfare of humanity.

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Inhibitory Effects of Sildenafil Citrate on the Tonus of Isolated Dog Internal Anal Sphincter

Cited by 8 publications

References 30 publications

A review of chronic anal fissure management

A review of chronic anal fissure management

Effect of sildenafil on wound healing: an experimental study

Oral Phosphodiesterase Type 5 Inhibitors: Nonerectogenic Beneficial Uses

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