2021
DOI: 10.3390/ijms222212601
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Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals

Abstract: Fungi are exposed to various environmental variables during their life cycle, including changes in CO2 concentration. CO2 has the potential to act as an activator of several cell signaling pathways. In fungi, the sensing of CO2 triggers cell differentiation and the biosynthesis of proteins involved in the metabolism and pathogenicity of these microorganisms. The molecular machineries involved in CO2 sensing constitute a promising target for the development of antifungals. Carbonic anhydrases (CAs, EC 4.2.1.1) … Show more

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Cited by 4 publications
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“…The newly developed compounds were also tested for the inhibition of two β-CAs from fungal pathogens. Indeed, in many pathogenic bacteria [41][42][43][44][45][46][47] and fungi [48][49][50][51][52], CAs belonging to several genetic familieshaverelevant physiologic functions and their inhibition may lead to anti-infective effects [53][54][55][56][57].…”
Section: Introductionmentioning
confidence: 99%
“…The newly developed compounds were also tested for the inhibition of two β-CAs from fungal pathogens. Indeed, in many pathogenic bacteria [41][42][43][44][45][46][47] and fungi [48][49][50][51][52], CAs belonging to several genetic familieshaverelevant physiologic functions and their inhibition may lead to anti-infective effects [53][54][55][56][57].…”
Section: Introductionmentioning
confidence: 99%