Inhibitory Effects of Twenty-Nine Compounds From Potentilla longifolia on Lipid Accumulation and Their Mechanisms in 3T3-L1 Cells

Ma, Qianqian; Li, Ye; Li, Wei; Lin, Shengxi; Zhao, Xiaoyan; Jin, Changchun; Liu, Guancheng; Liu, Huan; Sun, Yunpeng; Yuan, Hai‐Dan; Piao, Guang‐Chun

doi:10.3389/fphar.2020.555715

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…AMP‐activated protein kinase (AMPK) is a conserved serine/threonine protein kinase, which regulates hepatic lipid metabolism (Hardie, Ross, & Hawley, 2012；Ma et al, 2020). To explore the underlying mechanism of how CA inhibited hepatic steatosis, the signaling transducer, and the activator of transcription of AMPK/acetyl ‐ CoA carboxylase (ACC)/sterol‐regulatory element binding protein 1c (SREBP1c) signaling pathway were analyzed in liver tissues.…”

Section: Resultsmentioning

confidence: 99%

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathways

Liu

Cui

Gao

et al. 2021

Phytotherapy Research

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Hawthorn (Crataegus pinnatifida Bunge. var. major) is an edible and medicinal fruit that is very common in food and traditional Chinese medicine. Corosolic acid (CA), a pentacyclic triterpenoid, which is an active component of hawthorn (Crataegus pinnatifida Bunge. var. major), has been exhibiting various pharmacological activities such as antidiabetic, antibacterial, anticancer, antiinflammatory, and antioxidant effects. The study aimed to evaluate the effect of CA on non‐alcoholic steatohepatitis (NASH) in mice induced by 60 kcal% high‐fat diet (HFD) and carbon tetrachloride (CCl4). CA lowered liver index and serum AST, ALT, TG, and TC levels compared to those in the model group. Histological analyses of the liver tissues of mice treated with CA revealed significantly decreased number of lipid droplets and alleviated inflammation and fibrosis. CA inhibited the transcripts of pro‐fibrogenic markers (including α‐SMA, collagen I, and TIMP‐1) and the levels of pro‐inflammatory cytokines (including TNF‐α, IL‐1β, caspase‐1, and IL‐6) associated with hepatic fibrosis, and NF‐κB translocation and TGF‐β1/Smad2 and AMPK pathways. In addition, CA reduced lipid accumulation via the regulation of AMPK and NF‐κB activation in FFA‐induced steatotic HepG2 cells. CA also decreased α‐SMA, collagen I expressions, and Smad2 phosphorylation, which were reduced by TGF‐β1 treatment in LX2 cells. Our results suggested that CA ameliorated NASH through regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathways, and CA could be developed as a potential health functional food or therapeutic agent for NASH patients.

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Section: Resultsmentioning

confidence: 99%

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathways

Liu

Cui

Gao

et al. 2021

Phytotherapy Research

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“…Bioactive molecules to prevent LDA in the liver are actively searched to prevent hepatosteatosis and to combine with anticancer strategies. [84,[123][124][125] Plant extracts with anti-LDA activity are also searched. [88,126,127] For these reasons, phytochemical and pharmacological studies on C. ceramicus should be encouraged, notably using the fruits of the tree (known as Lantupak or Segera, in Borneo), which represent a renewable source of materials and are little studied at present.…”

Section: Discussionmentioning

confidence: 99%

“…Schltdl. ) [ 83–85 ] or the Korean medicinal plant Elaeagnus glabra Thunb., which is a climbing shrub with marked anti‐LDA properties. [ 86 ] This is the case also for the tropical medicinal plant Annona montana Macfad.…”

Section: Ceramicines As Regulators Of Lipogenesismentioning

confidence: 99%

“…Lipogenesis refers to the synthesis of fatty acids from nonlipidic ) [83][84][85] or the Korean medicinal plant Elaeagnus glabra THUNB., which is a climbing shrub with marked anti-LDA properties. [86] This is the case also for the tropical medicinal plant Annona montana MACFAD., for which extracts from the fruits and leaves have been shown to regulate glycemia and lipid synthesis in rats.…”

Section: Ceramicines As Regulators Of Lipogenesismentioning

confidence: 99%

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Limonoids isolated from Chisocheton ceramicus Miq. and the antiadipogenic mechanism of action of ceramicine B

Bailly

2024

Archiv der Pharmazie

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Different types of limonoids have been isolated from plants of the Chisocheton genus, notably from the species Chisocheton ceramicus Miq. which is largely distributed in the Indonesian archipelago and Malaysia region. A variety of natural products have been found in the bark of the tree and characterized as antimicrobial and/or antiproliferative agents. The isolated limonoids include chisomicines A–E, proceranolide, and a few other compounds. A focus is made on a large series of limonoids designated ceramicines A to Z including derivatives with antiparasitic activities, antioxidant, antimelanogenic, and antiproliferative effects and/or acting as regulators of lipogenesis. The lead compound in the series is ceramicine B functioning as a potent inhibitor of lipid droplet accumulation (LDA). Extracts from Chisocheton ceramicus and ceramicines have shown anti‐LDA effects, with little or no cytotoxic effects. Ceramicine B is the most active compound functioning as a regulator of lipid storage in cells and tissues. Ceramicine B is a transcriptional repressor of peroxisome proliferator‐activated receptor γ (PPARγ) and an inhibitor of phosphorylation of the transcription factor FoxO1, acting via an upstream molecular target. Targeting of glycogen synthase kinase‐3β is proposed, based on the analogy with structurally related limonoids known to target this enzyme, and supported by a molecular docking analysis. The target and pathway implicated in ceramicine B activity are discussed. The analysis shed light on ceramicine B as a natural product precursor for the design of novel compounds capable of reducing LDA in cells and of potential interest for the treatment of obesity, liver diseases, and other pathologies.

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Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways

Zhang,

Yuan,

Gao

et al. 2025

Biochemical Pharmacology

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Inhibitory Effects of Twenty-Nine Compounds From Potentilla longifolia on Lipid Accumulation and Their Mechanisms in 3T3-L1 Cells

Cited by 7 publications

References 43 publications

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathways

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathways

Limonoids isolated from Chisocheton ceramicus Miq. and the antiadipogenic mechanism of action of ceramicine B

Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways

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