Inhibitory Effects of Wasabi Isothiocyanates on Chemical Mediator Release in RBL-2H3 Rat Basophilic Leukemia Cells

Neolignan inhibitors of antigen-induced degranulation in RBL-2H3 cells from the needles of Pinus thunbergii

“…The clinical manifestations of type I allergic diseases are caused by the release of proinflammatory mediators, such as histamine, leukotrienes, and prostaglandins from IgE-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with the allergen [15]. When granules in basophils or mast cells activate, an enzyme β-hexosaminidase is usually secreted along with histamine, this enzyme is thus used as a biological marker for allergy and immunological research in rat basophilic leukemia 2H3 (RBL-2H3) cell line [16][17][18]. Therefore, inhibition of the release of β-hexosaminidase in RBL-2H3 cells has been used commonly as a reliable parameter to predict possible antiallergic activities of natural sources [19][20][21].…”

Extraction and Characterization of Glucosinolates and Isothiocyanates from Rape Seed Meal

“…Progoitrin is a precursor of the nutritionally harmful goitrin. Gluconapin is a precursor of 3-butenyl ITC, a compound showing potential antibacterial or anticancer effects 16,17 . The results of this study provide a foundation to improve our understanding of the GSLs composition in rapeseed meal.…”

Anti-allergic activity of the Morinda citrifolia extract and its constituents

“…[678] Definitive treatment has not been established, leaving only symptomatic therapy to ameliorate symptoms. [78] Safe, effective and convenient supplements or functional foods are in high demand given that allergy medications may cause side effects. [78]…”

“…[78] Safe, effective and convenient supplements or functional foods are in high demand given that allergy medications may cause side effects. [78]…”

“…[910] An antigen induces the production of specific immunoglobulin E (IgE) antibodies, which interact with receptors on the mast cell membrane surface. [810] Once mast cells are activated by the binding of IgE, degranulation occurs, which leads to the release of inflammatory mediators. This reaction is known as “immediate-type hypersensitivity (ITH)”.…”