2002
DOI: 10.1248/bpb.25.229
|View full text |Cite
|
Sign up to set email alerts
|

Inhibitory Mechanism of an Extract of Althaea officinalis L. on Endothelin-1-Induced Melanocyte Activation.

Abstract: When the skin is irradiated with UVB light, various cytokines are released, act on normal human melanocytes (NHMC), and induce them to synthesize melanin pigment, to proliferate and to differentiate, which leads to increased pigmentation.1-3) Endothelin-1 (ET-1), 2,4) basic fibroblast growth factor (b-FGF), 5) and a-melanocyte-stimulating hormone, [6][7][8] all of which are produced by normal human keratinocytes (NHKC) and are up-regulated following UVB irradiation, act as mitogens for NHMC. Furthermore, an in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
6
0
6

Year Published

2007
2007
2020
2020

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 22 publications
(14 citation statements)
references
References 25 publications
2
6
0
6
Order By: Relevance
“…Reported literature revealed that the majority of studies on the plant were conducted on the mucilage-rich roots, which were shown to have antitussive action (Nosal'ova et al, 1992), anti-inflammatory and immunostimulant activity (Scheffer & Konig, 1991), hypoglycemic activity (Tomoda et al, 1987), and to increase the phagocytic activity of macrophages (Wagner & Proksch, 1985). Additional studies reported activity against periodontopathic facultative aerobic and anaerobic bacteria (Iauk et al, 2003), and reduction of pigmentation by inhibiting endothelin-1-induced activation of normal human melanocytes (Kobayashi et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Reported literature revealed that the majority of studies on the plant were conducted on the mucilage-rich roots, which were shown to have antitussive action (Nosal'ova et al, 1992), anti-inflammatory and immunostimulant activity (Scheffer & Konig, 1991), hypoglycemic activity (Tomoda et al, 1987), and to increase the phagocytic activity of macrophages (Wagner & Proksch, 1985). Additional studies reported activity against periodontopathic facultative aerobic and anaerobic bacteria (Iauk et al, 2003), and reduction of pigmentation by inhibiting endothelin-1-induced activation of normal human melanocytes (Kobayashi et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…The signaling pathways activated by ETs are still controversial, with reports pointing to the participation of a G i protein (Imokawa et al, 1996(Imokawa et al, , 1997(Imokawa et al, , 2000, cAMP and PKA (Imokawa et al, 1996(Imokawa et al, , 1997, IP 3 (Kang et al, 1998;Kolch et al, 1993;Yada et al, 1991), Ca 2þ rise (Imokawa et al, 1997;Kang et al, 1998;Kobayashi et al, 2002;Yada et al, 1991), PKC (Imokawa et al, 1996(Imokawa et al, , 1997(Imokawa et al, , 2000, PLC (Imokawa et al, 2000;Kang et al, 1998), and MAPKs (Chen et al, 2007;Imokawa et al, 1996Imokawa et al, , 2000. PKC can phosphorylate and directly activate Raf-1 (Cacace et al, 1996;Kolch et al, 1993;Ueffing et al, 1997), which is one of the components of the MAPK signaling pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the prenyl-substituted polyphenols that did not reduce tyrosinase activity may be more effective as skin-whitening agents than as tyrosinase inhibitors. Recently, several melanin-biosynthesis inhibitors lacking tyrosinase inhibition have been reported [14] [15].…”
mentioning
confidence: 99%