Inhibitory Mechanism of Baicalein Against α-Glucosidase

He, Chengyun; Liu, Xiaoling; Sun, Junliang

doi:10.1177/1934578x19855825

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…The determination of α ‐Glucosidase inhibitory activity was carried out based on the method of He et al 28 . with some modifications.…”

Section: Methodsmentioning

confidence: 99%

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

Zhang,

Wang,

et al. 2024

J Sci Food Agric

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BackgroundMillet bran (MB), a byproduct of millet production, is rich in functional components, but has a low utilization rate. In recent years, researchers have shown that fermentation can improve the biological activities of cereals and their byproducts. This study used Bacillus natto to ferment millet bran to improve its added value and broaden the application areas of MB. The bioactive component content, physicochemical properties, and functional activities of millet bran extract (MBE) from fermented millet bran were determined.ResultsAfter fermentation, the contents of soluble dietary fiber (SDF), β‐glucan, polypeptides, polyphenols, flavones, and total amino acids increased by 92.0%, 164.4%, 111.4%, 32.5%, 16.4%, and 95.4%, respectively. Scanning electron microscopy revealed that the microscopic morphology of MBE changed from complete and dense blocks to loosely porous shapes after fermentation. After fermentation, the solubility, water holding capacity, and viscosity significantly increased, and the particle size decreased. Moreover, the glucose adsorption capacity (2.1 mmol/g), glucose dialysis retardation index (75.3%), and α‐glucosidase inhibitory (71.4%, mixed reversible inhibition) activity of the fermented MBE (FMBE) were greater than those of the unfermented MBE (0.99 mmol/g, 32.1%, and 35.1%, respectively). FMBE presented better cholesterol and sodium cholate (SC) adsorption properties, and the adsorption was considered inhomogeneous surface adsorption.ConclusionFermentation increased the bioactive component content and improved the physicochemical properties of MBE, thereby improving its hypoglycemic and hypolipidemic properties. This study will not only resolve the problem of millet bran waste but also promote the development of a higher value‐added application method for millet bran.This article is protected by copyright. All rights reserved.

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“…The determination of α ‐Glucosidase inhibitory activity was carried out based on the method of He et al 28 . with some modifications.…”

Section: Methodsmentioning

confidence: 99%

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

Zhang,

Wang,

et al. 2024

J Sci Food Agric

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“…Proinflammatory response suppression is attributed to its flavonoids, of which baicalin is the major member [ 106 ]. It has been reported to possess antidiabetic, antioxidant, and anti-inflammatory effects by activating insulin receptor substrate-1 (IRS-1) and GLUT-4, and involving AMPK signaling cascade [ 107 ], inhibiting α-glucosidase [ 108 ] and the production of TNF-α, IL-6, and other substances induced by lipopolysaccharide (LPS) [ 105 , 106 ]. In an examination of the effect on mice by Wang et al, baicalin 4 mg/kg per day was administered by the intragastric route to streptozocin-induced diabetic pregnant mice.…”

Section: Herbal-based Antidiabetic Medicines and Overview Of The Anti...mentioning

confidence: 99%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

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Chemical Constituents, Hypolipidemic, and Hypoglycemic Activities of Edgeworthia gardneri Flowers

Zhang,

Xue,

Zhao

et al. 2024

Plant Foods Hum Nutr

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Inhibitory Mechanism of Baicalein Against α-Glucosidase

Cited by 3 publications

References 19 publications

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

Chemical Constituents, Hypolipidemic, and Hypoglycemic Activities of Edgeworthia gardneri Flowers

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