Inhibitory role of opioid peptides in the regulation of aggressive and sexual behaviors in male japanese quails

Kotegawa, Takeru; Abe, Tamae; Tsutsui, Kazuyoshi

doi:10.1002/(sici)1097-010x(19970201)277:2<146::aid-jez6>3.0.co;2-p

Cited by 44 publications

(31 citation statements)

References 47 publications

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“…Low doses of morphine increase play, whereas opioid blockade with naloxone reduces play, which suggests that opioid reduction is associated with reduced pleasure and interaction in vigorous social relationships (55). Interestingly, naloxone has also been found to facilitate increased sexual behavior in some species (56). …”

Section: The Opioids and Borderline Personality Disordermentioning

confidence: 99%

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

Stanley¹,

Siever²

2010

AJP

248

152

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Borderline personality disorder is characterized by affective instability, impulsivity, identity diffusion, and interpersonal dysfunction. Perceived rejection and loss often serve as triggers to impulsive, suicidal, and self-injurious behavior, affective reactivity, and angry outbursts, suggesting that the attachment and affiliative system may be implicated in the disorder. Neuropeptides, including the opioids, oxytocin, and vasopressin, serve a crucial role in the regulation of affiliative behaviors and thus may be altered in borderline personality disorder. While clinical data are limited, the authors propose alternative neuropeptide models of borderline personality disorder and review relevant preclinical research supporting the role of altered neuropeptide function in this disorder in the hope of stimulating more basic research and the development of new treatment approaches.

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Section: The Opioids and Borderline Personality Disordermentioning

confidence: 99%

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

Stanley¹,

Siever²

2010

AJP

248

152

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“…Opioids and dopamine in the mPOA are strongly implicated in male sexual behavior in mammals and birds (Hull et al, 1995; Kleitz-Nelson et al, 2010b; Kotegawa et al, 1997; Van Furth et al, 1995). In starlings, converging data demonstrate that opioids act in the mPOA to modulate sexually-motivated song in a complex manner (Kelm et al, 2011; Kelm-Nelson et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Contributions of testosterone and territory ownership to sexually-motivated behaviors and mRNA expression in the medial preoptic area of male European starlings

Spool

Stevenson

Angyal

et al. 2016

Hormones and Behavior

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Animals integrate social information with their internal endocrine state to control the timing of behavior, but how these signals are integrated in the brain is not understood. The medial preoptic area (mPOA) may play an integrative role in the control of courtship behavior, as it receives projections from multiple sensory systems, and is central to the hormonal control of courtship behavior across vertebrates. Additionally, data from many species implicate opioid and dopaminergic systems in the mPOA in the control of male courtship behavior. We used European starlings to test the hypothesis that testosterone (T) and social status (in the form of territory possession) interact to control the timing of courtship behavior by modulating steroid hormone-, opioid- and dopaminergic-related gene expression in the mPOA. We found that only males given both T and a nesting territory produced high rates of courtship behavior in response to a female. T treatment altered patterns of gene expression in the mPOA by increasing androgen receptor, aromatase, mu-opioid receptor and preproenkephalin mRNA and decreasing tyrosine hydroxylase mRNA expression. Territory possession did not alter mRNA expression in the mPOA, despite the finding that only birds with both T and a nesting territory produced courtship behavior. We propose that T prepares the mPOA to respond to the presence of a female with high rates of courtship song by altering gene expression, but that activity in the mPOA is under a continuous (i.e. tonic) inhibition until a male starling obtains a nesting territory.

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“…Blocking opioid receptors with naloxone in the VTA of male rats increases ASB (reviewed by van Furth and van Ree, 1996). Administering naloxone to the preoptic area in male Japanese quail increases sexual behaviors toward females whereas administration of a d receptor-specific agonist decreases these behaviors (Kotegawa et al, 1997). Infusing a d receptor agonist in the female rat POM inhibits lordosis, a female CSB (Sinchak et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

Woods

Deviche

Corbitt

2010

Journal of Chemical Neuroanatomy

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Inhibitory role of opioid peptides in the regulation of aggressive and sexual behaviors in male japanese quails

Cited by 44 publications

References 47 publications

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model

Contributions of testosterone and territory ownership to sexually-motivated behaviors and mRNA expression in the medial preoptic area of male European starlings

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

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