Inibidores da via de sinalização do Sonic hedgehog: avaliação de seus efeitos in vitro em leiomioma e leiomiossarcoma uterinos

Abstract

ATCC American Type Culture Collection ATRX ATRX chromatin remodeler B2M Beta-2-microglobulin BAX BCL2 associated X, apoptosis regulator BCL-2 BCL2 apoptosis regulator BMP4 Bone morphogenetic protein 4 CA125 Cancer antigen 125 CAPPESQ Comissão de Ética para Análise de Projetos de Pesquisa CCND1 Cyclin D1 cDNA Complementary Deoxyribonucleic Acid CIT Citoplasma CK Creatine kinase c-MET MET proto-oncogene c-MYC MYC proto-oncogene COSMIC Catalog of Somatic Mutations in Cancer CYP1A1 Cytochrome P450 family 1 subfamily A member 1 CYP1B1 Cytochrome P450 family 1 subfamily B member 1 DDCT Delta-Delta-Ct DHH Desert hedgehog DMSO dimetilsulfóido DNA Deoxyribonucleic acid DNMT DNA (cytosine-5)-methyltransferase DPB Drug-binding pocket ECD Extracellular domain ECL Extracelular FAPESP Fundação de Amparo à Pesquisa do Estado de São Paulo FDA Food and Drug Administration