Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

Okamoto, Eiji; Yano, Tetsuya; Shiraishi, Yasuyuki; Miura, Hidekazu; Yambe, Tomoyuki; Mitamura, Yoshinori

doi:10.1111/aor.12558

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…Eiji Okamoto et al of Tokai University, Sapporo, Japan reported on their axial flow blood pump, “valvo pump,” that is implanted at the aortic valve position. It is anastomosed to the aorta with polytetrafluoroethylene (PTFE) cuffs on the inflow and outflow ports.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2015: A Year in Review

Malchesky¹

2016

Artificial Organs

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In this Editor's Review, articles published in 2015 are organized by category and briefly summarized. We aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ Replacement, Recovery, and Regeneration. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, the International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. We take this time also to express our gratitude to our authors for providing their work to this journal. We offer our very special thanks to our reviewers who give so generously of their time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers, the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2015: A Year in Review

Malchesky¹

2016

Artificial Organs

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“…As an alternative option, a serially connected axial‐flow blood pump (AFBP) enables pulsatile blood perfusion to the downstream end‐organs without any rotational speed modulation 10 . Upstream of the coronary sinus is a suitable position for implantation of the AFBP to avoid disturbance of coronary and cerebral circulation 11 ––this is exactly the concept of the “valvo‐pump” 12,13 .…”

Section: Introductionmentioning

confidence: 99%

In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

et al. 2020

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In this study, we developed a trans‐valve left ventricular assist device (LVAD) that unites a rear‐impeller axial‐flow blood pump (AFBP) and a polymer membrane valve placed at the aortic valve position. The diameter and length of the rear impeller AFBP was 12 and 63 mm, respectively. The polymer membrane valve was similar to the jelly‐fish valve consisting of a valve leaflet made of silicone rubber (thickness 0.5 mm), valve ring (diameter: 25 mm), and valve spokes. The trans‐valve LVAD was examined in a mock circulation. An implantable pulsatile flow (PF) VAD was connected to an atrial reservoir to simulate the left ventricle (LV), and the Hall valve was worn in the inflow port, and the trans‐valve LVAD was placed in the outflow port as an outflow valve. When the motor rotational speed increased to 26 400 rpm, the mean aortic flow increased from 4.2 to 5.3 L/min, mean aortic pressure increased from 83.4 to 100 mm Hg, and mean motor current of the implantable PF VAD decreased from 1.18 to 0.94 A (unloading effect on LV −21%). The energy equivalent pressure increased from 85.2 to 102 mm Hg, and surplus hemodynamic energy (SHE) decreased by −15.4% from the baseline. In conclusion, the trans‐valve LVAD has an advantage of preserving pulsatility without any complicated mechanism and is a novel and promising LV support device.

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“…Then, we developed a new axial flow blood pump (second valvo pump) using our original brushless motor and a passive magnetic bearing . In addition, the hemodynamic change under ventricular assist device (VAD) using the second valvo pump connected in series with the natural heart was investigated using in vivo studies . The experimental results showed that the second valvo pump enabled pulsatile blood perfusion to the end organs downstream from the pump without rotational speed modulation; however, the potential risk of decreased blood flow caused by a pressure drop upstream of the pump was measured.…”

Section: Introductionmentioning

confidence: 99%

“…6 In addition, the hemodynamic change under ventricular assist device (VAD) using the second valvo pump connected in series with the natural heart was investigated using in vivo studies. 7,8 The experimental results showed that the second valvo pump enabled pulsatile…”

Section: Introductionmentioning

confidence: 99%

Development of rear‐impeller axial flow blood pump for realization of axial flow blood pump installed at aortic valve position

et al. 2019

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In this study, rear‐impeller axial flow blood pumps (RIAFBP) were developed to realize a trans‐valve axial ventricular assist device (VAD) which consists of the latter blood pump and a polymer monomembrane aortic valve, such as the jellyfish valve. The motor of the RIAFBP is installed in the left ventricle, and its impeller is placed at the aortic valve position. In the prototype RIAFBP, the rotation of the motor is sustained by polyethylene bushings. The RIAFBP has a length of 50 mm and diameter of 19.6 mm. The miniature RIAFBP has the same construction as that of the prototype; however, it employs a ceramic bearing and fin bearing to improve endurance and to reduce blood stagnation. The miniature RIAFBP has a length of 63 mm and diameter of 12 mm. Both RIAFBPs were examined by an in vitro experiment using a 33% glycerin solution. The prototype RIAFBP achieved a maximum pump outflow of 8.5 L/min against a pump head of 100 mm Hg at a rotational speed of 12 000 rpm. The miniature RIAFBP achieved 7 L/min against a pump head of 70 mm Hg at a rotational speed of 21 600 rpm. In conclusion, the miniature RIAFBP has enough pump performance to realize the trans‐valve axial VAD.

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Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

Cited by 11 publications

References 10 publications

Artificial Organs 2015: A Year in Review

Artificial Organs 2015: A Year in Review

In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

Development of rear‐impeller axial flow blood pump for realization of axial flow blood pump installed at aortic valve position

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