Initial experience with the endoscopic application of fibrin tissue adhesive in the upper gastrointestinal tract

Groitl, H.; Scheele, J.

doi:10.1007/bf00312692

Cited by 37 publications

(16 citation statements)

References 7 publications

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“…Endoscopic filling of the fistula with fibrin glue is reported as an effective treatment [17]. Thrombin and fibrinogen provide the surgical seal, and adhesion strength Fig.…”

Section: Discussionmentioning

confidence: 99%

Successful endoscopic clipping and application of fibrin glue for an esophago-mediastinal fistula after an esophagectomy

et al. 2011

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A 64-year-old man visited our hospital complaining of abdominal discomfort. A 2-cm-long 0-IIc ? IIa esophageal superficial carcinoma was detected in the middle third of the thoracic esophagus with endoscopy and esophagography. Computed tomography (CT) did not detect any metastasis. The patient underwent videoassisted thoracic surgery of the esophagus (VATS-E). Anastomotic leakage and a thoracic abscess were detected 16 days after the operation. Repeated thoracic drainages and conservative therapy with enteral nutrition were continued for approximately 1 month, but an esophago-mediastinal fistula and small mediastinal cavity remained. Additional drainage using interventional radiology (IVR) reduced the size of the cavity, but could not cure the esophago-mediastinal fistula, 68 days after the operation. The occurrence of an esophago-respiratory fistula followed by a thoracic abscess is a very serious and frequently fatal complication. We performed endoscopic clipping and filling with fibrin glue and succeeded in closing the fistula. Oral intake was started after training in swallowing, and the patient was discharged from hospital 172 days after the operation. One year after the operation he has no sign of a recurrence of the tumor or fistula. We demonstrated a case in which an esophago-mediastinal fistula was successfully repaired by endoscopic clipping with fibrin glue after an operation.

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“…Endoscopic filling of the fistula with fibrin glue is reported as an effective treatment [17]. Thrombin and fibrinogen provide the surgical seal, and adhesion strength Fig.…”

Section: Discussionmentioning

confidence: 99%

Successful endoscopic clipping and application of fibrin glue for an esophago-mediastinal fistula after an esophagectomy

et al. 2011

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“…Subsequently, with the introduction of different types of biological tissue adhesives and the development of dual and triple lumen catheters in 1984, fibrin glues have been used in the endoscopic treatment of fistulas of the digestive tract [34] . However, only proximal and distal digestive tract fistulas are accessible for endoscopic evaluation and management.…”

Section: Discussionmentioning

confidence: 99%

Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant

Ávalos-González

Portilla-deBuen²,

Leal-Cortés³

et al. 2010

WJG

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“…Considering the elevated concentration of the different components present inside the Tissucol P.U., histological studies showed that a soaring proliferation of fibroblasts is present only 4 hours after medication in humans [20]. During the first week the proliferation of newly growing capillary bed is present (as demonstrated in rabbit bone, known to be refractory to regeneration), leading to a wide tissue repairing [19].…”

Section: The Fibrin Glue In Surgery Why?mentioning

confidence: 98%

Drug Targets in Colonoscopic Polypectomy: Biological Sealants with Special Reference to Fibrin-Glue (Tissucol)

Venezia¹

2005

curr drug targets immune endocr metabol disord

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The increasing outpatient use of colonoscopy in the diagnostic study and prophylaxis of colon diseases has allowed early identification of polypoid neoformations, thus indicating their increased incidence during the asymptomatic phase. In this respect, the application of biological sealants immediately before the polypectomy has represented a novel therapeutic strategy in the treatment of these preneoplastic lesions. The injection of biological sealants with needle under the polyp peduncle or sub-mucosa has demonstrated a protective action on the electrocoagulated area, an anti-haemorrhagic effect owing to the strengthened seal of the eschar that is formed, and a facilitated tissue regeneration, respectively. The author report his experience acquired over the past five years with regard to the use of biological sealant in colonoscopic polypectomy and conclude that biological sealants, a human fibrin glue, which utilises components of the human plasma, may allow a more generous removal of neoformations, the absence of post-polypectomy complications and, consequently, the dramatic reduction of time of patient's admission in the hospital. In fact, all patients were discharged after two hours from polypectomy, thus implying a better quality of life for patients, in the absence of post-operative complications and a reduction of non-medical costs.

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Initial experience with the endoscopic application of fibrin tissue adhesive in the upper gastrointestinal tract

Cited by 37 publications

References 7 publications

Successful endoscopic clipping and application of fibrin glue for an esophago-mediastinal fistula after an esophagectomy

Successful endoscopic clipping and application of fibrin glue for an esophago-mediastinal fistula after an esophagectomy

Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant

Drug Targets in Colonoscopic Polypectomy: Biological Sealants with Special Reference to Fibrin-Glue (Tissucol)

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