Initial hazard assessment of ethyl(dimethyl)(tetradecyl)ammonium ethyl sulfate: Genotoxicity tests and combined repeated-dose and reproductive/developmental toxicity screening in rats

Matsumoto, Mariko; Takano, Masao; Takabe, Michihito; Yamaguchi, Noriko; Iso, Takako; Shigeta, Yoshiyuki; Murata, Yoshitaka; Hirose, Nozomu; Inoue, Kaoru; Hirose, Akihiko

doi:10.1016/j.yrtph.2021.104914

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…We report the results of an OECD TG 422 study and hazard assessment of polyoxymethylene. Our earlier work on hazard assessment of other substances is also available in scientific journals (Kawashima et al, 2020;Matsumoto et al, 2021;Igarashi et al, 2020Igarashi et al, , 2018aIgarashi et al, , 2018b. Study reports are accessible via the Japan Existing Chemical Database (JECDB, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Matsumoto¹,

Fujii

Hirose³

et al. 2021

Fundam. Toxicol. Sci.

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The Japanese government requires risk assessment of chemicals under the Chemical Substances Control Law (CSCL). Toxicity data for polyoxymethylene (paraformaldehyde; CAS No.: 30525-89-4) for human health are insufficient though the chemical needs a screening assessment under the CSCL. Thus, polyoxymethylene was selected by the Safety Examination of Existing Chemicals and Safety Programmes of the Ministry of Health, Labour and Welfare (MHLW) to assess repeated-dose and reproductive/developmental toxicity. A combined toxicity screening was conducted following the OECD TG422. Male and female rats were administered the test chemical once daily by gavage at doses of 0 (control), 20, 60, or 200 mg/kg bw from 14 days before mating for a total of 28 to 61 days. The 200 mg/ kg bw/day dose caused a significant decrease in food consumption. Histopathological examination found ulcers in the forestomach and glandular stomach, and erosion and inflammatory cell infiltration in the submucosa of the glandular stomach at the end of dosing in both sexes. Inflammatory cell infiltration in the submucosa of the glandular stomach was also observed in both sexes after the recovery period. No reproductive and developmental toxicity was observed even at the highest dose. A no-observed-adverse-effect level (NOAEL) for repeated-dose toxicity was 60 mg/kg bw/day, and a NOAEL for reproductive and developmental toxicity was 200 mg/kg bw/day, the highest dose tested.

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Section: Discussionmentioning

confidence: 99%

“…The screening assessment procedure and hazard classification are reported by Matsumoto et al (2021). A hazard assessment value (D-value) is calculated by dividing a no-observed-adverse-effect level (NOAEL) by an uncertainty factor (UF).…”

Section: Hazard Assessment Of Polyoxymethylene For a Screening Assessment Under The Csclmentioning

confidence: 99%

Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Matsumoto¹,

Fujii

Hirose³

et al. 2021

Fundam. Toxicol. Sci.

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“…The reproductive toxicities are very important in ecological risk and hazard evaluation. It was reported that QACs signi cantly decreased reproduction, caused birth defects and impacted the development of ovaries in mice and rats (Jiao et al 2017, Hrubec et al 2021, Matsumoto et al 2021). In the yeast assays and in vitro cell line studies, QACs impacted hormones that are important in reproduction (Hrubec et al 2021, Liwarska-Bizukojc et al 2021.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Toxicities of Tetradecyltrimethylammonium Chloride and Tetradecyltrimethylammonium Bromide on Caenorhabditis elegans over Four Consecutive Generations

Zhang,

Ding,

2024

Chem. Res. Chin. Univ.

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Quaternary ammonium compounds (QACs) become emerging pollutants and their toxicities earn increasing attentions. So far, their reproductive toxicities were poorly investigated, and their effects over generations were even less explored. In the present study, reproductive toxicities of two QACs, i.e., tetradecyltrimethylammonium chloride (TTAC) and tetradecyltrimethylammonium bromide (TTAB) were studied on Caenorhabditis elegans with a consecutive exposure over four generations (from F1 to F4). The effects of TTAC on total reproduction showed stimulation and inhibition which oscillated from F1 to F4, and such oscillation was also observed in the effects on initial reproduction. The effects of TTAB on the total reproduction commonly showed stimulation over generations. The greatest stimulation was in F2, and it was accompanied with inhibition on the initial reproduction but stimulation on the reproduction duration. Further mechanisms exploration demonstrated that both TTAC and TTAB signi cantly disturbed the levels of SPE8, SPE9, Vg, MSP and VAB-1 and the expressions of vab-1, ceh-18, set-2, met-2 and mes-4 over generations. Such disturbances demonstrated that both QACs impacted the reproductive processes in multiple aspects including oocyte meiosis, gonadal support and germline development.Further analysis also showed that the effects of both TTAC and TTAB in parents were connected with those in the offspring, which highlighted the conjunctive roles of reproduction in responses of adjacent generations. In addition, the differences the effects of TTAC and TTAB also demonstrated the anionic in uences on the QACs' toxicities.

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Reproductive & developmental toxicity of quaternary ammonium compounds

Bobic,

Harbolic,

Warner

2024

Biology of Reproduction

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Quaternary ammonium compounds (QACs) are a class of chemicals commonly used as disinfectants in household and healthcare settings. Their usage has significantly increased in recent years due to the COVID-19 pandemic. In addition, QACs have replaced the recently banned disinfectants triclosan and triclocarban in consumer products. QACs are found in daily antimicrobial and personal care products such as household disinfectants, mouthwash, and hair care products. Due to the pervasiveness of QACs in daily use products, humans are constantly exposed. However, little is known about the health effects of everyday QAC exposure, particularly effects on human reproduction and development. Studies that investigate the harmful effects of QACs on reproduction are largely limited to high-dose studies, which may not be predictive of low dose, daily exposure, especially as QACs may be endocrine disrupting chemicals. This review analyzes recent studies on QAC effects on reproductive health, identifying knowledge gaps, and recommending future directions in QAC-related research.

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Initial hazard assessment of ethyl(dimethyl)(tetradecyl)ammonium ethyl sulfate: Genotoxicity tests and combined repeated-dose and reproductive/developmental toxicity screening in rats

Cited by 5 publications

References 11 publications

Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats

Reproductive Toxicities of Tetradecyltrimethylammonium Chloride and Tetradecyltrimethylammonium Bromide on Caenorhabditis elegans over Four Consecutive Generations

Reproductive & developmental toxicity of quaternary ammonium compounds

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