Initial hypothalamic involvement is the major risk factor for impaired prognosis and quality of life in childhood craniopharyngioma regardless of chosen treatment strategies – Results of KRANIOPHARYNGEOM 2000

Hoffmann, Anika; Gebhardt, Ursel; Sterkenburg, AS; Warmuth-Metz, M.; Kortmann, RD; Falldum, A; Pietsch, Torsten; Calaminus, Gabriele; Sörensen, N.; Müller, HL

doi:10.1055/s-0032-1330091

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“…Obesity is one of the major causes of morbidity and reduced quality of life in children and adolescents with craniopharyngioma [2], leading to premature cardiovascular diseases, psychosocial problems, and failure to achieve academic potential, especially in children with hypothalamic involvement of the tumor [3]. …”

Section: Introductionmentioning

confidence: 99%

Longitudinal Changes in Body Mass Index in Children with Craniopharyngioma

et al. 2014

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Objective: We investigated the relationship of body mass index at presentation and pituitary status with long-term changes in BMI over a period of 5 years. Study Design: Craniopharyngioma patients (n = 25) attending a tertiary pediatric endocrine center were divided into three groups based on their BMI at presentation [BMI ≥2 standard deviation scores (SDS), 0-1.99 SDS, and <0 SDS) and then analyzed for trends of BMI over a period of up to 5 years. Results: Median (interquartile range) BMI SDS and hypopituitarism at presentation versus at the 5-year follow-up were as follows: BMI SDS ≥2 group (n = 10): 3.55 (0.68), 6/10 versus 3.76 (1.13), 8/10; BMI SDS 0-1.99 group (n = 11): 1.68 (1.05), 3/11 versus 1.64 (2.04), 7/11, and BMI SDS <0 group (n = 4): -0.23 (0.93), 2/4 versus 0.61, 4/4. At the 5-year follow-up, 10/10, 7/11, and 1/4 subjects when divided in groups according to BMI at presentation were obese. Conclusions: Our data indicate that obesity at presentation, rather than panhypopituitarism either at or after presentation, predicts obesity 5 years after diagnosis. However, obesity at presentation is not always associated with the subsequent development of panhypopituitarism. Pediatric craniopharyngioma subjects who have BMI SDS ≥2 at presentation require early and aggressive intervention to help prevent the complications of obesity.

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Section: Introductionmentioning

confidence: 99%