Initial Misdiagnosis of Cerebral Venous Thrombosis: A Case Report

Alluri,

doi:10.4021/jmc1612e

J Med Cases

2013

DOI: 10.4021/jmc1612e

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Initial Misdiagnosis of Cerebral Venous Thrombosis: A Case Report

Alluri Alluri¹

Abstract: Cerebral venous thrombosis (CVT) is a rare condition with an incidence ranging from 2 to 4 cases per million people per year. Its presentation is highly variable and can include headaches, changes in vision, focal neurological deficits, seizures and coma. Treatment of CVT remains controversial, particularly regarding long-term anticoagulation. We report a case of a 35-year-old Asian male with a history of anti-thrombin III deficiency that was not adequately anticoagulated. He presented with an acute and progre… Show more

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2023

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“…However, missed diagnosis often occur, especially in the emergency department, due to various risk factors and atypical clinical presentation. 3…”

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confidence: 99%

Deep Learning Algorithm Enables Cerebral Venous Thrombosis Detection With Routine Brain Magnetic Resonance Imaging

Zhang

et al. 2023

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Background: Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease. Routine brain magnetic resonance imaging is commonly used to diagnose CVT. This study aimed to develop and evaluate a novel deep learning (DL) algorithm for detecting CVT using routine brain magnetic resonance imaging. Methods: Routine brain magnetic resonance imaging, including T1-weighted, T2-weighted, and fluid-attenuated inversion recovery images of patients suspected of CVT from April 2014 through December 2019 who were enrolled from a CVT registry, were collected. The images were divided into 2 data sets: a development set and a test set. Different DL algorithms were constructed in the development set using 5-fold cross-validation. Four radiologists with various levels of expertise independently read the images and performed diagnosis within the test set. The diagnostic performance on per-patient and per-segment diagnosis levels of the DL algorithms and radiologist’s assessment were evaluated and compared. Results: A total of 392 patients, including 294 patients with CVT (37±14 years, 151 women) and 98 patients without CVT (42±15 years, 65 women), were enrolled. Of these, 100 patients (50 CVT and 50 non-CVT) were randomly assigned to the test set, and the other 292 patients comprised the development set. In the test set, the optimal DL algorithm (multisequence multitask deep learning algorithm) achieved an area under the curve of 0.96, with a sensitivity of 96% (48/50) and a specificity of 88% (44/50) on per-patient diagnosis level, as well as a sensitivity of 88% (129/146) and a specificity of 80% (521/654) on per-segment diagnosis level. Compared with 4 radiologists, multisequence multitask deep learning algorithm showed higher sensitivity both on per-patient (all P <0.05) and per-segment diagnosis levels (all P <0.001). Conclusions: The CVT-detected DL algorithm herein improved diagnostic performance of routine brain magnetic resonance imaging, with high sensitivity and specificity, which provides a promising approach for detecting CVT.

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“…However, missed diagnosis often occur, especially in the emergency department, due to various risk factors and atypical clinical presentation. 3…”

mentioning

confidence: 99%

Deep Learning Algorithm Enables Cerebral Venous Thrombosis Detection With Routine Brain Magnetic Resonance Imaging

Zhang

et al. 2023

Stroke

View full text Add to dashboard Cite

show abstract

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Initial Misdiagnosis of Cerebral Venous Thrombosis: A Case Report

Cited by 1 publication

References 11 publications

Deep Learning Algorithm Enables Cerebral Venous Thrombosis Detection With Routine Brain Magnetic Resonance Imaging

Deep Learning Algorithm Enables Cerebral Venous Thrombosis Detection With Routine Brain Magnetic Resonance Imaging

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