Initial Muscle Quality Affects Individual Responsiveness of Interleukin-6 and Creatine Kinase following Acute Eccentric Exercise in Sedentary Obese Older Women

Neto, Ivo Vieira de Sousa; Nascimento, Dahan da Cunha; Prestes, Jonato; Fonseca, Eduardo Fernandes da; Celes, Rodrigo; Rolnick, Nicholas; Barbalho, Yuri Gustavo de Sousa; Silva, Alessandro de Oliveira; Stival, Marina Morato; Lima, Luciano Ramos de; Funghetto, Silvana Schwerz

doi:10.3390/biology11040537

Cited by 5 publications

(7 citation statements)

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“…Fifteen studies reported the acute effect of resistance exercise on circulating muscle proteins (Table 6 ). Four of these studies were conducted exclusively in females [ 50 , 61 – 63 ], seven were conducted in males [ 45 , 46 , 49 , 55 , 56 , 64 , 65 ], and four were conducted with a mixed sample [ 57 , 58 , 66 , 67 ]. Seven of the studies included a younger group of adults for comparison [ 45 , 46 , 49 , 50 , 57 , 58 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven of the studies included a younger group of adults for comparison [ 45 , 46 , 49 , 50 , 57 , 58 , 66 ]. Eleven of the studies involved an eccentric exercise protocol [ 45 , 46 , 50 , 56 – 58 , 61 – 63 , 65 , 66 ], three of which were solely using elbow flexors [ 45 , 46 , 50 ], one used an eccentric-concentric protocol of the knee extensors [ 66 ]. The remainder used concentric protocols involving the whole body or lower limbs [ 49 , 55 , 64 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies reported the acute effect of resistance exercise on circulating muscle proteins (Table 6). Four of these studies were conducted exclusively in females [50,[61][62][63], seven were conducted in males [45,46,49, three of which were solely using elbow flexors [45,46,50], one used an eccentric-concentric protocol of the knee extensors [66]. The remainder used concentric protocols involving the whole body or lower limbs [49,55,64,67].…”

Section: Biological Markers Of Muscle Damage Circulating Muscle Proteinsmentioning

confidence: 99%

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Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review

et al. 2023

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Background Resistance exercise is recommended for maintaining muscle mass and strength in older adults. However, little is known about exercise-induced muscle damage and recovery from resistance exercise in older adults. This may have implications for exercise prescription. This scoping review aimed to identify and provide a broad overview of the available literature, examine how this research has been conducted, and identify current knowledge gaps relating to exercise-induced muscle damage and recovery from resistance exercise in older adults. Methods Studies were included if they included older adults aged 65 years and over, and reported any markers of exercise-induced muscle damage after performing a bout of resistance exercise. The following electronic databases were searched using a combination of MeSH terms and free text: MEDLINE, Scopus, Embase, SPORTDiscus and Web of Science. Additionally, reference lists of identified articles were screened for eligible studies. Data were extracted from eligible studies using a standardised form. Studies were collated and are reported by emergent theme or outcomes. Results A total of 10,976 possible articles were identified and 27 original research articles were included. Findings are reported by theme; sex differences in recovery from resistance exercise, symptoms of exercise-induced muscle damage, and biological markers of muscle damage. Conclusions Despite the volume of available data, there is considerable variability in study protocols and inconsistency in findings reported. Across all measures of exercise-induced muscle damage, data in women are lacking when compared to males, and rectifying this discrepancy should be a focus of future studies. Current available data make it challenging to provide clear recommendations to those prescribing resistance exercise for older people.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Biological Markers Of Muscle Damage Circulating Muscle Proteinsmentioning

confidence: 99%

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Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review

et al. 2023

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“…It has been reported that IL-6 can induce GLUT4 translocation to the cell membrane in response to insulin-stimulated glucose disposal, and it can also improve glucose tolerance, possibly through the AMPK signaling pathway [ 78 – 80 ]. Several studies have reported eccentric exercise-mediated IL-6 release, which might serve as a possible link between eccentric training-related systemic adaptation and metabolic processes [ 81 – 83 ]. However, there is a controversy in the literature whether the magnitude of IL-6 response is more significant in eccentric exercise.…”

Section: Eccentric Contraction-induced Changes In Myokine Productionmentioning

confidence: 99%

Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity

Szűcs,

Pipicz,

Szabó

et al. 2023

Sports Med - Open

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There is a growing body of evidence showing the importance of physical activity against civilization-induced metabolic diseases, including type 2 diabetes (T2DM) and obesity. Eccentric contraction, when skeletal muscles generate force by lengthening, is a unique type of skeletal muscle activity. Eccentric contraction may lead to better power production characteristics of the muscle because eccentric contraction requires less energy and can result in higher tension. Therefore, it is an ideal tool in the rehabilitation program of patients. However, the complex metabolic effect (i.e., fat mass reduction, increased lipid oxidation, improvement in blood lipid profile, and increased insulin sensitivity) of the eccentric contraction alone has scarcely been investigated. This paper aims to review the current literature to provide information on whether eccentric contraction can influence metabolic health and body composition in T2DM or obesity. We also discussed the potential role of myokines in mediating the effects of eccentric exercise. A better understanding of the mechanism of eccentric training and particularly their participation in the regulation of metabolic diseases may widen their possible therapeutic use and, thereby, may support the fight against the leading global risks for mortality in the world.

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“…14 Therefore, MQ could help health professionals design better rehabilitation programs to enhance independence in the aging population. 15 In applied research settings, field-based estimates of MQI (dividing handgrip strength by upper limb muscle mass, body weight, or BMI) provide a similar prediction for mobility and lower extremity performance in communitydwelling older adults when compared to the most expensive method to determine MQI (eg, laboratory, normalized by lean mass through dual-energy x-ray (DXA)). 16 In our laboratory, we observed a strong correlation effect between field MQI and laboratory MQI in octogenarians, which highlights the importance of simpler measures.…”

Section: Introductionmentioning

confidence: 99%

Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women

Neto¹,

Diniz²,

Alves³

et al. 2023

CIA

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The muscle quality index (MQI) is associated with numerous health outcomes in adults; however, the effects of distinct MQI on functional capacity in obese older women have not yet been fully investigated. Thus, we investigated the contribution of different muscle quality indices on TUG performance prediction in obese older women. We secondarily evaluated the association between MQI, aerobic capacity performance (Treadmill performance and 6-minute walk test), and obesity indices (BMI, body fat percentage, and neck, waist, and hip circumference). Methods: Participants included 64 obese older women (mean age 67.05 ± 5.46 years, body fat ≥ 35%). General anthropometric, health history, body composition, treadmill exercise, and functional test (Time up and go) measures were collected. A hydraulic dynamometer was used to assess muscle strength, and Dual Energy X-ray Absorptiometry (DXA) to identify body fat percentage. The field MQI was defined as the highest reading divided by the subject's body mass index (BMI), while the laboratory MQI was obtained by the ratio of grip strength to the entire arm muscle in kilograms measured by DXA. A hierarchical multiple regression was performed to predict TUG-test performance. Results: An increase in field MQI of one unit is associated with a decrease of 2.59 seconds in the TUG test (β = −0.540; p = 0.004). There was no association between laboratory MQI and TUG performance (β = 0.067; p = 0.712). Furthermore, field MQI displays a positive correlation (p < 0.05) with aerobic capacity performance (6-minute walk test and peak O 2 consumption) and a negative correlation (p < 0.05) with diverse obesity indices (neck and waist circumference, body fat, and BMI). Conclusion: MQI displayed an important prediction with TUG-test, a positive correlation with aerobic capacity, and a negative correlation with obesity indices.

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Initial Muscle Quality Affects Individual Responsiveness of Interleukin-6 and Creatine Kinase following Acute Eccentric Exercise in Sedentary Obese Older Women

Cited by 5 publications

References 58 publications

Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review

Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review

Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity

Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women

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