Initial nicotine sensitivity in humans as a function of impulsivity

Perkins, Kenneth A.; Lerman, Caryn; Coddington, Sarah; Jetton, Christopher; Karelitz, Joshua L.; Scott, John; Wilson, Annette

doi:10.1007/s00213-008-1231-7

Cited by 74 publications

(73 citation statements)

References 75 publications

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“…Adolescent sensation seekers are at increased risk for use of various drugs, including alcohol, tobacco, and marijuana (Martin et al, 2002(Martin et al, , 2004Sargent et al, 2010). Young adult high sensation seekers also are more sensitive to the effects of drugs (self-administration, positive subjective effects) than are low sensation seekers under controlled laboratory conditions (Stoops et al, 2007;Perkins et al, 2008;Fillmore et al, 2009;Kelly et al, 2009), suggesting that this facet is present before problem use. Neurobiological studies indicate that the underlying neurocircuitry associated with sensation seeking involves, at least in part, the nucleus accumbens.…”

Section: A Individual Differencesmentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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Section: A Individual Differencesmentioning

confidence: 99%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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“…The development of sensation seeking in relation to subsequent smoking has been much less studied (Crawford, Pentz, Chou, Li, & Dwyer, 2003). Explanatory mechanisms for the association between sensation seeking and the initiation of smoking include heightened reward sensitivity to nicotine, underestimation of risk, consorting with other sensation-seeking peers, and expectancies for positive reinforcement from smoking (Doran et al, 2012;Perkins et al, 2008;Wills, Windle, & Cleary, 1998;Yanovitzky, 2005).…”

Section: Sensation Seeking As An Etiological Variablementioning

confidence: 99%

Smoking Trajectories Across High School: Sensation Seeking and Hookah Use

Hampson

Tildesley

Andrews

et al. 2013

Nicotine & Tobacco Research

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“…For instance, sensation-seeking (similar to noveltyseeking), which has been defined as a need for varied, novel and stimulating experiences, 21 has been associated with heightened sensitivity to the rewarding effects of drugs. 22,23 Sensation-seeking has also been associated with rewardseeking in animal studies, 24 and it seems to be independent of rash impulsiveness. 25 However, many studies of pathologic gambling use the terms impulsiveness and sensation -seeking indistinctly, and most of them report high levels of both traits in this population.…”

Section: Introductionmentioning

confidence: 96%

Effect of executive functioning, decision-making and self-reported impulsivity on the treatment outcome of pathologic gambling

Álvarez-Moya

Ochoa

Jiménez‐Murcia

et al. 2011

jpn

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Background: Impairments in self-regulatory behaviour reflect a deficit in executive functioning and decision-making, as well as higher levels of self-reported impulsivity, and may be involved in the development and maintenance of addictive disorders. We sought to explore the association between self-reported impulsivity and neurocognitive measures, and their association with treatment outcome in pathologic gambling. Methods: We assessed patients with pathologic gambling using executive functioning and decision -making tests and self-report measures of impulsivity. Patients underwent cognitive-behavioural therapy (CBT) for pathologic gambling. Results: We included 88 patients (8% women) in our study. High self-reported extravagance was associated with poor performance in the Iowa Gambling Task (IGT)-ABCD version. High impulsiveness, low disorderliness, high exploratory excitability (trend), poor backward block span and poor IGT-EFGH scores (trend) predicted dropout. We observed no self-reported or neurocognitive predictors of relapse or number of treatment sessions attended. Limitations: Most participants were slot-machine gamblers seeking treatment. No follow-up data and no control group were included in the study. The missing sample (i.e., individuals who were recruited and assessed in the pretreatment stage but who chose not to begin treatment) had higher extravagance scores than the final sample. Conclusion: Neurocognitive reward sensitivity was related to self-reported overspending behaviour. Self-regulatory impairments (especially rash impulsiveness and punishment sensitivity) and executive dysfunction predicted only dropout of CBT in participants with pathologic gambling. Different neurocognitive processes and personality traits might mediate treatment response to psychological therapy of pathologic gambling according to the specific target variable assessed. Research Paper Effect of executive functioning, decision-making IntroductionImpairments in self-regulatory behaviour seem to be involved in the development and maintenance of pathologic gambling and other addictive disorders.1,2 From a neuropsychological point of view, this impairment reflects a deficit in executive functioning and decision-making. 3,4 Executive functioning includes functions such as cognitive flexibility (set-shifting), which is associated with orbitofrontal functioning, and working memory, planning and abstract thinking, which are associated with dorsolateral prefrontal functioning. [5][6][7] However, decision-making seems to be mainly associated with activation of the ventromedial prefrontal cortex. 5,8 People with pathologic gambling have shown impaired performance in tasks measuring both concepts. Specifically, studies report deficits in cognitive inhibition, complex executive functions and attention. [9][10][11] This population also shows impairments in decision-making.12-14 Decision-making impairments are observed in impulsive individuals in general. Specifically, impulsive individuals show an insensitivity to variations in re...

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Initial nicotine sensitivity in humans as a function of impulsivity

Cited by 74 publications

References 75 publications

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Smoking Trajectories Across High School: Sensation Seeking and Hookah Use

Effect of executive functioning, decision-making and self-reported impulsivity on the treatment outcome of pathologic gambling

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