Initial Occupational Exposure to Lead

Forni, Alessandra; Cambiaghi, G; Secchi, G. C.

doi:10.1080/00039896.1976.10667193

Cited by 57 publications

(5 citation statements)

References 11 publications

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“…Exposure to lead in this study did not affect mitotic activity, as both groups had similar NDI (NDI exp =2.17 vs NDI cont= 2.13), which is in line with the report by Palus et al (41). Minozzo et al (58), in contrast, found significantly higher NDI in battery recycling workers than controls and other studies (99)(100)(101) showed increased mitotic activity in lead exposure.…”

Section: Resultssupporting

confidence: 91%

Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation

Kašuba

Milić

Želježić

et al. 2020

Archives of Industrial Hygiene and Toxicology

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Manufacture of lead-containing products has long been associated with various health risks. To get an insight into the related genotoxic risks, we conducted a biomonitoring study in 50 exposed workers and 48 matched controls using a battery of endpoints that sensitively detect the extent of genome instability in peripheral blood lymphocytes. The levels of primary DNA damage were estimated with the alkaline comet assay, while cytogenetic abnormalities were determined with the cytokinesis-block micronucleus (CBMN) cytome assay. Additionally, CBMN slides of 20 exposed and 16 control participants were subjected to fluorescence in situ hybridisation (FISH), coupled with pancentromeric probes to establish the incidence of centromere-positive micronuclei, nuclear buds, and nucleoplasmic bridges. Blood lead levels (B-Pb) were measured with atomic absorption spectrometry. To further characterise cumulative effects of occupational exposure, we measured erythrocyte protoporphyrin (EP) concentrations and delta-aminolevulinic acid dehydratase (ALAD) activity in blood. We also assessed the influence of serum folate (S-folate) and vitamin B12 (S-B12) on genome stability. Compared to controls, occupationally exposed workers demonstrated significantly higher B-Pb (298.36±162.07 vs 41.58±23.02), MN frequency (18.71±11.06 vs 8.98±7.50), centromere positive MN (C+ MN) (8.15±1.8 vs 3.69±0.47), and centromere negative MN (C- MN) (14.55±1.80 vs 4.56±0.89). Exposed women had significantly higher comet tail intensity (TI) and length (TL) than control women. Furthermore, workers showed a positive correlation between age and nuclear buds and MN, between MN and years of exposure, and between S-B12 levels and TI and ALAD activity, while a negative correlation was found between TI and B-Pb. These findings suggest that occupational settings in the manufacture of lead-containing products pose significant genotoxic risks, which calls for developing more effective work safety programmes, including periodical monitoring of B-Pb and genetic endpoints.

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Section: Resultssupporting

confidence: 91%

Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation

Kašuba

Milić

Želježić

et al. 2020

Archives of Industrial Hygiene and Toxicology

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“…This assumption is also compatible with various kinds of earlier data on the elimination (1,(11)(12)(13)(14)20,(27)(28)(29)36,37,40,46,50,53,54,56,65), if a second , slow compartment is taken into consideration, and on the accumulation (5,24,27,28,37,38,48,65,67) of PbB.…”

Section: Discussionsupporting

confidence: 73%

Kinetics of lead in blood after the end of occupational exposure.

Schütz¹,

Skerfving²,

Ranstam³

et al. 1987

Scand J Work Environ Health

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“…Lead is excreted by the adult at a rate of approximately 30 lg/day by the kidney (Kehoe 1969). With increasing body stores, this may rise considerably but is rarely more than 20 mg/day (Chisolm et al 1975;Forni et al 1976). Excretion may be due both to glomerular filtration and in part to shedding of tubular epithelial cells where the lead tends to concentrate (Bennett 1985).…”

Section: Introductionmentioning

confidence: 98%

?-adrenergic receptor density and adenylate cyclase activity in lead-exposed rat brain after cessation of lead exposure

Chang

Tsao

et al. 2004

Arch Toxicol

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To understanding the reversible or irreversible harm to the beta-adrenergic system in the brain of lead-exposed rats, this study sets up an animal model to estimate the change in the sympathetic nervous system of brain after lead exposure was withdrawn. We address the following topics in this study: (a) the relationship between withdrawal time of lead exposure and brain beta-adrenergic receptor, blood lead level, and brain lead level in lead-exposed rats after lead exposure was stopped; and (b) the relationship between lead level and beta-adrenergic receptor and cyclic AMP (c-AMP) in brain. Wistar rats were chronically fed with 2% lead acetate and water for 2 months. Radioligand binding was assayed by a method that fulfilled strict criteria of beta-adrenergic receptor using the ligand [125I]iodocyanopindolol. The levels of lead were determined by electrothermal atomic absorption spectrometry. The c-AMP level was determined by radioimmunoassay. The results showed a close relationship between decreasing lead levels and increasing numbers of brain beta-adrenergic receptors and brain adenylate cyclase activity after lead exposure was withdrawn. The effect of lead exposure on the beta-adrenergic system of the brain is a partly reversible condition.

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Initial Occupational Exposure to Lead

Cited by 57 publications

References 11 publications

Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation

Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation

Kinetics of lead in blood after the end of occupational exposure.

?-adrenergic receptor density and adenylate cyclase activity in lead-exposed rat brain after cessation of lead exposure

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