Initial Postoperative Hemoglobin Values Are Independently Associated With One-Year Mortality in Patients Undergoing Double-Lung Transplantation Requiring Intraoperative Transfusion

Menger, Johannes; Koch, Stefan; Mouhieddine, M.; Schwarz, Štefan; Höetzenecker, Konrad; Jaksch, Péter; Steinlechner, Barbara; Dworschak, Martin

doi:10.1053/j.jvca.2020.12.040

Cited by 5 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a prospective multicenter cohort study on 1225 patients, transfusion of more than 1 L of PRBCs was associated with a nearly 2-fold increased risk of developing PGD grade 3 [ 30 ]. Menger and colleagues even found in the multivariate analysis that transfusing more than 5 units of PRBCs was significantly associated with mortality in LuTX patients [ 31 ]. In order to elucidate whether FSLT1 is introduced via transfused blood products we measured FSTL1 concentrations in PRBCs and FFPs.…”

Section: Discussionmentioning

confidence: 99%

Follistatin-like 1 and Biomarkers of Neutrophil Activation Are Associated with Poor Short-Term Outcome after Lung Transplantation on VA-ECMO

Veraar

Kirschner

Schwarz

et al. 2022

Biology

View full text Add to dashboard Cite

The investigation of biomarkers associated with undesired outcome following lung transplantation (LuTX) is essential for a better understanding of the underlying pathophysiology, an earlier identification of susceptible recipients and the development of targeted therapeutic options. We therefore determined the longitudinal perioperative course of putative cytokines related to neutrophil activation (chemokine CC motif ligand 4 (CCL-4), interleukin (IL)-23 and Lipocalin 2 (LCN2)) and a cytokine that has been implicated in graft-versus-host disease (Follistatin-like 1 (FSTL1)) in 42 consecutive patients undergoing LuTX. We plotted receiver-operating curves (ROC) to assess the predictive power of the measured cytokines for short-term outcomes namely primary graft dysfunction (PGD), early complications requiring extracorporeal membrane oxygenation (ECMO), and a high postoperative sequential organ failure assessment (SOFA). All cytokines increased immediately after surgery. ROC analyses determined significant associations between CCL4 and a high SOFA score (area under the curve (AUC) 0.74 (95%CI:0.5–0.9; p < 0.05), between LCN2 and postoperative ECMO support (AUC 0.73 (95%CI:0.5–0.9; p < 0.05), and between FSTL1 and PGD (AUC 0.70 (95%CI:0.5–0.9; p < 0.05). The serum concentrations of the neutrophil-derived cytokines LCN2 and CCL4 as well as FSTL1 were all related to poor outcome after LuTX. The specific predictive power, however, still has to be assessed in larger trials. The potential role of FSTL1 as a biomarker in the development of PGD could be of great interest particularly since this protein appears to play a crucial role in allograft tolerance.

show abstract

Section: Discussionmentioning

confidence: 99%