Initial presentation of human papillomavirus‐related head and neck cancer: A retrospective review

Khalid, Mian; Ting, Peter; Pai, Akila; Russo, Jack; Bakst, Richard L.; Chai, Raymond L.; Teng, Marita S.; Genden, Eric M.; Miles, Brett A.

doi:10.1002/lary.27296

Cited by 30 publications

(29 citation statements)

References 44 publications

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“…This result was unexpected, given that HPVrelated OPSCC is classically associated with sexual activity, and most Middle Eastern countries are historically more conservative [6]. However, the patient profile of our study sample generally fits that of an HPV-related patient as described in the literature [6][7][8]. Most HPVrelated patients in our study were males who presented with nodal metastases and advanced stage at diagnosis.…”

Section: Discussionmentioning

confidence: 56%

“…An important aspect of our study will be its impact on health education and on raising awareness about HPV-related OPSCC, which could play a role in controlling the increasing prevalence of this entity and promoting vaccination among young adults. With the advent of vaccines for prevention of HPV-related cervical cancer, the incidence of HPV-related OPSCC might decrease with the decrease of HPV-positivity and transmission as a whole [8]. However, a recent study conducted in Lebanon found an HPV vaccination uptake rate of 2.5% and a rate of awareness about HPV infection of 34% amongst mothers of schoolgirls in their sample [27].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, HPV-related OPSCC is more likely to arise from tonsillar tissue compared to other subsites of the oropharynx, which attests to its infectious etiology [5]. Interestingly, HPV-related OPSCC is also more likely to present at an advanced stage, with significant nodal disease despite small primary tumors; regardless, its prognosis tends to be more favorable [7,8]. All of the previously mentioned characteristics demonstrate that HPV-related OPSCC is clearly a unique entity both clinically and demographically.…”

Section: Introductionmentioning

confidence: 98%

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HPV-related oropharyngeal cancer prevalence in a middle eastern population using E6/E7 PCR

Maroun

Feghali

Traboulsi

et al. 2020

Infect Agents Cancer

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Background: Given the paucity of data and widely variable rates that have been reported, the main objective of this study was to examine the prevalence of HPV-positivity in oropharyngeal squamous cell carcinoma (OPSCC) in Middle Eastern patients presenting to one of the region's largest tertiary care centers using polymerase chain reaction (PCR) amplification of the HPV E6/E7 oncogenes, a highly sensitive and specific method of detection. Methods: Medical charts and archived pathological specimens were obtained for patients diagnosed with biopsy proven oropharyngeal cancer who presented to the American University of Beirut Medical Center between 1972 and 2017. DNA was extracted from paraffin-embedded specimens and tested for 30 high-risk and low-risk papilloma viruses using the PCR-based EUROarray HPV kit (EuroImmun). Results: A total of 57 patients with oropharyngeal cancer were initially identified; only 34 met inclusion/exclusion criteria and were included in the present study. Most patients were males (73.5%) from Lebanon (79.4%). The most common primary tumor site was in the base of tongue (50%), followed by the tonsil (41.2%). The majority of patients (85.3%) tested positive for HPV DNA. Conclusion: The prevalence of HPV-positivity amongst Middle Eastern OPSCC patients, specifically those from Lebanon, may be far greater than previously thought. The Lebanese population and other neighboring Middle Eastern countries may require a more vigilant approach towards HPV detection and awareness. On an international level, further research is required to better elucidate non-classical mechanisms of HPV exposure and transmission.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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HPV-related oropharyngeal cancer prevalence in a middle eastern population using E6/E7 PCR

Maroun

Feghali

Traboulsi

et al. 2020

Infect Agents Cancer

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“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide [1]. In the last few decades, there has been an increase in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) related to human papilloma virus (HPV), a distinct entity from the traditional tobacco-and alcohol-related OPSCC [2].…”

Section: Introductionmentioning

confidence: 99%

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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Objectives To investigate the correlation between histogram-based Dynamic Contrast-Enhanced magnetic resonance imaging (DCE-MRI) parameters and positron emission tomography with 18 F-fluorodeoxyglucose (18 F-FDG-PET) values in oropharyngeal squamous cell carcinoma (OPSCC), both in primary tumors (PTs) and in metastatic lymph nodes (LNs). Methods 52 patients with a new pathologically-confirmed OPSCC were included in the present retrospective cohort study. Imaging including DCE-MRI and 18 F-FDG PET/CT scans were acquired in all patients. Both PTs and the largest LN, if present, were volumetrically contoured. Quantitative parameters, including the transfer constants, K trans and K ep , and the volume of extravascular extracellular space, v e , were calculated from DCE-MRI. The percentiles (P), P10, P25, P50, P75, P90, and skewness, kurtosis and entropy were obtained from the histogram-based analysis of each perfusion parameter. Standardized uptake values (SUV), SUV max , SUV peak , SUV mean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated applying a SUV threshold of 40%. The correlations between all variables were investigated with the Spearman-rank correlation test. To exclude false positive results under multiple testing, the Benjamini-Hockberg procedure was applied.

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“…A recent retrospective analysis of 207 patients with OPSCC found that patients with HPV-positive OPSCC were most likely to present with a neck mass (56%), sore throat (11%), or oral mass (11%). 14 Furthermore most HPV-positive patients in this study presented at a tumor, node, metastasis stage of IVa (57%), with the tonsil (60%) and base of tongue (40%) being the most common primary tumor site. 14 If a patient presents to the office with a history suspicious for OPSCC, it is recommended that providers conduct a formal head and neck examination that includes inspection of the oral cavity, palatine tonsils, base of tongue, and cervical lymph nodes.…”

Section: Screening and Presentationmentioning

confidence: 72%

Human Papillomavirus-Associated Head and Neck Cancer

et al. 2021

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Oropharyngeal squamous cell carcinoma (OPSCC) has historically been attributable to tobacco and alcohol exposure and saw a decline in incidence after societal norms shifted away from smoking. In recent decades, this disease has had a re-emergence due to human papillomavirus (HPV) infection, now surpassing cervical cancer as the number 1 cause of HPV-related cancer in the United States. HPVpositive OPSCC differs from HPV-negative disease in epidemiology, prognosis, treatment, and prevention. Additionally, there is a deficit in awareness of the causal relationship between HPV and OPSCC. This, coupled with low vaccination rates, puts primary care providers in a unique position to play a vital role in prevention and early diagnosis. In this review, we highlight the epidemiology, screening, patient presentation, diagnosis, prognosis, and prevention of HPV-positive OPSCC, with a focus on the primary care provider's role.

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Initial presentation of human papillomavirus‐related head and neck cancer: A retrospective review

Abstract: 4. Laryngoscope, 2018.

Cited by 30 publications

References 44 publications

HPV-related oropharyngeal cancer prevalence in a middle eastern population using E6/E7 PCR

HPV-related oropharyngeal cancer prevalence in a middle eastern population using E6/E7 PCR

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Human Papillomavirus-Associated Head and Neck Cancer

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