Initial Results From the National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis

Armstrong, Lori; Derkay, Craig S.; Reeves, William C.

doi:10.1001/archotol.125.7.743

Cited by 194 publications

(162 citation statements)

References 8 publications

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“…However, only a few cases of RRP affecting elderly patients have been reported (3). The incidence of adult RRP in the United States is estimated to be 1.8 cases per 100,000 of the population (6). Despite this, <50 cases of solitary endobronchial papillomas have been reported in the English literature (7).…”

Section: Discussionmentioning

confidence: 99%

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Feng¹,

Wang²,

Chen³

et al. 2015

Oncology Letters

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Abstract. The present study described a rare case of malignant conversion of a solitary papilloma in the trachea, in addition to reviewing the current literature. A 54-year-old male presented with a cough, sputum and dyspnea. Chest computed tomography revealed a mediastinal soft-tissue mass in the trachea. A tumor biopsy, performed using a flexible bronchofiberscope, identified a squamous cell papilloma with moderate to severe atypical hyperplasia, as well as the formation of squamous cell carcinoma. Polymerase chain reaction analysis did not detect presence of human papilloma virus in the tumor. The patient was subsequently treated with radiotherapy and no evidence of recurrence was observed during a two-year follow-up period. To the best of our knowledge, this is the first study to describe the malignant conversion of a solitary papilloma in the trachea, which was subsequently treated with radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Feng¹,

Wang²,

Chen³

et al. 2015

Oncology Letters

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“…El segundo pico de aparición ocurre entre los 20 y 40 años, posiblemente por activación de un virus latente desde la niñez o exposición en la vida adulta por contacto sexual. La manifestación clínica de la enfermedad antes de los 3 años es un factor de riesgo para que el paciente presente enfermedad severa [6][7][8][9][10][11] siendo otro de ellos la infección por el VPH tipo 11. Éste se asocia a presentación más precoz, tiende a requerir cirugía más frecuente, tiene un mayor riesgo de extensión broncopulmonar y más frecuentemente requiere traqueostomía 4 .…”

Section: Introductionunclassified

Papilomatosis respiratoria recurrente y el rol de la vacunación antiVPH

2013

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMENLa papilomatosis respiratoria recurrente es una enfermedad infrecuente de la vía aereodigestiva, que afecta a niños y adultos, causada por el virus papiloma humano subtipos 6 y 11. La enfermedad tiene un curso impredecible y ha sido reportada la extensión pulmonar y la transformación maligna.Actualmente todos los tratamientos disponibles, tanto médicos como quirúrgicos, son sólo paliativos, enfocados a mantener una vía aérea adecuada y una calidad de voz aceptable. Se han desarrollado dos vacunas contra el virus papiloma humano con el fin de prevenir el cáncer cervicouterino causado por éste. Una de estas vacunas también incluye los subtipos asociados a la papilomatosis, por lo que la vacunación masiva podría disminuir drásticamente la incidencia de la enfermedad.Palabras clave: Papilomatosis, virus papiloma humano, vacunación. ABSTRACTRecurrent respiratory papillomatosis is a rare disease of the aerodigestive tract that affects children and adults, caused by the human papiloma virus subtypes 6 and 11. The disease has a unpredictable course and pulmonary spread and malignant transformation have been reported.All the medical and surgical treatments available are only palliative and are focused on keeping a adequate airway and an acceptable voice quality. Two vaccines have been developed against the human papilloma virus for the prevention of cervical cancer. One of these vaccines also includes the subtypes associated with papillomatosis so widespread vaccination could drastically diminish the incidence of the disease.

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“…The incidence of RPR varies and is estimated to range from 18 cases per million for AO to 43 cases per million for JO. 2 The AO TP affects male and female in a 4:1 ratio. TP can present at any age and is reported in all ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Tracheal papillomatosis

Harris

Chalhoub

2011

Chron Respir Dis

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Tracheal papillomatosis (TP) is a benign condition characterized by papillomatous growth of the bronchial epithelium that involves the trachea. This abnormal growth is a result of infection with human papilloma virus (HPV). Two subtypes of HPV were found in most cases of TP, HPV-6 and HPV-11. TP, presents in two forms, the juvenile onset (JO) or adult onset (AO). The clinical presentation is typically nonspecific and it ranges from mild symptoms like cough to life-threatening conditions like upper airway obstruction. Treatment depends on the location of the papillomas and age of the patient and the plan of therapy is usually made on an individual basis. Treatment can range from observation with symptomatic control to specific medical therapy and multiple surgeries in case of recurrence or progressively worsening disease. The recent invention of HPV vaccine is expected to be the first step in eradicating respiratory papillomatosis.

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Initial Results From the National Registry for Juvenile-Onset Recurrent Respiratory Papillomatosis

Cited by 194 publications

References 8 publications

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Papilomatosis respiratoria recurrente y el rol de la vacunación antiVPH

Tracheal papillomatosis

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