Objective: There is a paucity of robust clinical data on major postoperative complications following robotic-assisted resections for primary lung cancer. This study assessed the incidence and outcomes of patients who experienced major complications after robotic anatomical pulmonary resections.Methods: This was a multicenter, retrospective review of patients who underwent robotic anatomical pulmonary resections from 2002-2018. Major complications were defined as Grade III or higher complications according to the Clavien-Dindo Classification. Statistical analysis was performed based on patient-, surgeon-and treatment-related factors.Results: During the study period, 1264 patients underwent robotic anatomical pulmonary resections, and 64 major complications occurred in 54 patients (4.3%). Univariate analysis found male gender, FEV1, DLCO, neoadjuvant therapy, and extensiveness of resection to be associated with an increased likelihood of a major postoperative complication. Patient age, performance status, BMI, reoperation status, and surgeon experience did not have a significant impact on major complications. Patients who experienced at least one major complication were at higher risk for an ICU stay of greater than 24 hours (17.0% vs 1.4%, p<0.001) and prolonged hospitalization (8.5 vs