Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment

Isoda, Kazuya; Nakade, Junya; Suga, Yukio; Fujita, Arimi; Shimada, Tsutomu; Sai, Yoshimichi

doi:10.1097/ftd.0000000000000870

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Meanwhile, Nakayama et al 7 showed that systemic clearance of vancomycin decreased in patients treated for more than 4 weeks, without any change in CrCl. In addition, Isoda et al 16 investigated the factors associated with an increased serum vancomycin concentration during treatment and found that a high CRP level at the beginning of vancomycin administration was a risk factor, independent of reduced renal function. However, the underlying mechanisms have not yet been clarified.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic variability of vancomycin in patients with nosocomial meningitis

Okamoto

Furuya

Ito

et al. 2022

Clinical Pharmacy Therapeu

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What is known and objective: High doses of vancomycin are required early in the treatment of nosocomial meningitis. However, the dosage is often reduced later during treatment, irrespective of renal function. This study was designed to investigate the pharmacokinetic variability of vancomycin and the associated factors throughout the treatment course for patients with nosocomial bacterial meningitis.Methods: This study included 17 patients who received vancomycin for nosocomial bacterial meningitis at the Tokyo Women's Medical University Yachiyo Medical Center from April 2013 to May 2020. All patients had their serum vancomycin concentrations and cerebrospinal fluid (CSF) parameters measured within 7 days of initiating treatment (early period) and after 8 days (later period) of treatment.Results and discussion: The relative error between the predicted serum vancomycin concentration and the measured value was significantly higher in the later period than in the early period. In 13 patients who did not have their dosing interval shortened, the vancomycin dosage/serum vancomycin concentration/estimated glomerular filtration rate (D/C/eGFR) ratio significantly decreased in the later period.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetic variability of vancomycin in patients with nosocomial meningitis

Okamoto

Furuya

Ito

et al. 2022

Clinical Pharmacy Therapeu

View full text Add to dashboard Cite

show abstract

Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment

Abstract: Background: Vancomycin has a narrow therapeutic window, and an increase in its serum concentration-to-dose ratio during treatment can cause renal toxicity. Therefore, this study was aimed at finding a marker to identify patients at risk of increasing serum vancomycin during treatment.

Cited by 1 publication

References 19 publications

Pharmacokinetic variability of vancomycin in patients with nosocomial meningitis

Pharmacokinetic variability of vancomycin in patients with nosocomial meningitis

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