Initial stress in biomechanical models of atherosclerotic plaques

Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions

“…Model construction procedures based on in vivo data are considerably different from earlier models based on idealized geometry or ex vivo data (Tang et al, 2004; Tang, 2006; Yang et al, 2007). Residual stress and zero-stress plaque morphology need to be handled properly to get accurate stress/strain predictions (Ohayon et al, 2007; Huang et al, 2009; Speelman et al, 2011). …”

“…It is well known that residual stress has considerable effect on stress/strain calculations (Ohayon et al, 2007; Speelman et al, 2011). In vivo plaque morphology data are acquired when the vessel is under physiological pressure, stretch and other tethering forces.…”

Topical bromfenac for post-cataract extraction: A systematic review and pooled analysis

“…The clinical benefits of bromfenac have been extensively discussed in several comparative studies including the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, as well as postoperative inflammation. Bromfenac was found to be 3.7, 6.5, and 18 times more potent than diclofenac, 31 amfenac, 32 and ketorolac, 33 respectively in inhibiting COX-2 activity. Since the clinical consensus has not been reached concerning the safety of bromfenac, we performed the current pooled analysis to offer evidence for the safety and efficacy of topical bromfenac in reducing overall ocular pain and inflammation during the whole postoperative period.…”

Inverse modelling of image-based patient-specific blood vessels: zero-pressure geometry andin vivostress incorporation

“…As such, the stress tensor gets updated towards the in vivo stress tensor and the strain tensor gets implicitly updated by a multiplicative split of the deformation gradient tensor F 0,i = F 0,i−1 .F i−1,i [7,18]. Afterwards, the zero-pressure geometry can be constructed by reducing the luminal pressure to 0 Pa [19]. According to [5] the last pressure increment has to be chosen extremely small to return a final equilibrium configuration.…”

“…According to [5] the last pressure increment has to be chosen extremely small to return a final equilibrium configuration. The method allows the use of a black box structural solver if the finite element code is able to update the initial stress tensor field with each iteration [19]. A similar approach of prestressing was used earlier by Pinsky et al to include the internal stress state in the cornea under the presence of the full intraocular pressure load through a fixed point iteration instead of increasing the pressure incrementally [20].…”