Initial Test of a Proton Radiographic System

Moffett, D.R.; Colton, E.; Concaildi, G. A.; Hoffman, E. W.; Klem, R.; Knott, M.; Kramer, S.L.; Martin, Ronald L.; Parker, E. F.; Passi, A. R.; Schultz, P. F.; Stockley, R. L.; Timm, R. E.; Skaggs, Lester S.; Steward, V. W.

doi:10.1109/tns.1975.4327982

Cited by 18 publications

(10 citation statements)

References 1 publication

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“…This first image is reproduced in Figure 1a where the contrast is generated by the addition of a 100-μm pennant-shaped sheet of aluminium. Other proton radiographic works followed 22 , 23 but the use of fluence as the mechanism for contrast limited the application of projection radiography to thin samples.…”

Section: Historical Surveymentioning

confidence: 99%

Proton radiography and tomography with application to proton therapy

Poludniowski¹,

Allinson²,

Evans³

2015

BJR

149

163

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Proton radiography and tomography have long promised benefit for proton therapy. Their first suggestion was in the early 1960s and the first published proton radiographs and CT images appeared in the late 1960s and 1970s, respectively. More than just providing anatomical images, proton transmission imaging provides the potential for the more accurate estimation of stopping-power ratio inside a patient and hence improved treatment planning and verification. With the recent explosion in growth of clinical proton therapy facilities, the time is perhaps ripe for the imaging modality to come to the fore. Yet many technical challenges remain to be solved before proton CT scanners become commonplace in the clinic. Research and development in this field is currently more active than at any time with several prototype designs emerging. This review introduces the principles of proton radiography and tomography, their historical developments, the raft of modern prototype systems and the primary design issues.

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Section: Historical Surveymentioning

confidence: 99%

Proton radiography and tomography with application to proton therapy

Poludniowski¹,

Allinson²,

Evans³

2015

BJR

149

163

View full text Add to dashboard Cite

show abstract

“…The image contrast was based on the attenuation of the energy fluence of the proton beams. The initially used passive 2D solid state detectors [ 62 ] were replaced from mid 70’s by active integrating electronic detection systems using collimators [ 12 , 38 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Helium ion beam imaging for image guided ion radiotherapy

Martišíková¹,

Gehrke²,

Berke³

et al. 2018

Radiat Oncol

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BackgroundIon beam radiotherapy provides potential for increased dose conformation to the target volume. To translate it into a clinical advantage, it is necessary to guarantee a precise alignment of the actual internal patient geometry with the treatment beam. This is in particular challenging for inter- and intrafractional variations, including movement. Ion beams have the potential for a high sensitivity imaging of the patient geometry. However, the research on suitable imaging methods is not conclusive yet. Here we summarize the research activities within the “Clinical research group heavy ion therapy” funded by the DFG (KFO214). Our aim was to develop a method for the visualization of a 1 mm thickness difference with a spatial resolution of about 1 mm at clinically applicable doses.MethodsWe designed and built a dedicated system prototype for ion radiography using exclusively the pixelated semiconductor technology Timepix developed at CERN. Helium ions were chosen as imaging radiation due to their decreased scattering in comparison to protons, and lower damaging potential compared to carbon ions. The data acquisition procedure and a dedicated information processing algorithm were established. The performance of the method was evaluated at the ion beam therapy facility HIT in Germany with geometrical phantoms. The quality of the images was quantified by contrast-to-noise ratio (CNR) and spatial resolution (SR) considering the imaging dose.ResultsUsing the unique method for single ion identification, degradation of the images due to the inherent contamination of the outgoing beam with light secondary fragments (hydrogen) was avoided. We demonstrated experimentally that the developed data processing increases the CNR by 350%. Consideration of the measured ion track directions improved the SR by 150%. Compared to proton radiographs at the same dose, helium radiographs exhibited 50% higher SR (0.56 ± 0.04lp/mm vs. 0.37 ± 0.02lp/mm) at a comparable CNR in the middle of the phantom. The clear visualization of the aimed inhomogeneity at a diagnostic dose level demonstrates a resolution of 0.1 g/cm2 or 0.6% in terms of water-equivalent thickness.ConclusionsWe developed a dedicated method for helium ion radiography, based exclusively on pixelated semiconductor detectors. The achievement of a clinically desired image quality in simple phantoms at diagnostic dose levels was demonstrated experimentally.

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“…The concept of the range-edge proton radiography was proposed by Koehler in 1968 [1]. Subsequently, Koehler and others [2][3][4][5] demonstrated that the high-contrast images obtained by proton radiography can provide improved imaging of low contrast lesions in human specimens over conventional x-ray techniques. Hanson described a proton CT method in 1981 [6,7], in which projections necessary for computer tomography (CT) reconstructions were obtained by measuring the proton energy losses.…”

Section: Introductionmentioning

confidence: 99%

Concept and design of charged particle optics using energy Fourier plane collimation

Gao

Tao

Zhou

et al. 2014

Phys. Rev. ST Accel. Beams

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Charged particle radiography has become a promising new approach in the field of transmission radiography because of the invention of the magnetic imaging lens. The using of the imaging lens makes it possible for thick objects to get significantly improved transmission radiography. Currently, the conventional charged particle radiography only uses the information of the flux attenuation and the angular scattering of the transmitted particles to determine the properties of the sample. However, the energy loss of the incident particles introduced by ionizations throughout the object limits the spatial resolution of the image because of the chromatic blur. In this paper a new concept of imaging lens that uses the information of the energy loss is proposed. With a specially designed imaging lens, the information of the energy loss could result in apparent contrast in the final image. This design procedure of the energy loss imaging lens is presented, and a preliminary design is verified by numerical simulations. Experimental demonstration is also expected on a cyclotron at the Institute of Fluid Physics, CAEP.

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Initial Test of a Proton Radiographic System

Cited by 18 publications

References 1 publication

Proton radiography and tomography with application to proton therapy

Proton radiography and tomography with application to proton therapy

Helium ion beam imaging for image guided ion radiotherapy

Concept and design of charged particle optics using energy Fourier plane collimation

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