Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

Jin, Ying; Liu, Hang; Chu, Lei; Yang, Jin; Li, Xiuyang; Zhou, Hang; Jiang, Haitao; Shi, Lei; Weeks, Jason; Rainbolt, Joshua; Yang, Changjiang; Xue, Thomas; Pan, Haobo; Deng, Zhongliang; Xie, Chao; Cui, Xu; Ren, Youliang

doi:10.1016/j.bioactmat.2024.05.040

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.05.040

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Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

Ying Jin,

Hang Liu,

Lei Chu

et al.

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2024

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Cited by 3 publications

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Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Zhou,

Ren,

Zou

et al. 2024

Adv Healthcare Materials

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Implant‐associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due to the formation of Staphylococcal abscess community within the bone marrow and bacterial colonization in the osteocyte lacuno‐canalicular network (OLCN). To address this, antimicrobial peptides (HHC36)‐loaded titania nanotubes (NTs) are developed on titanium screws (Ti‐NTs‐P‐A), which integrate pH‐responsive polymethacrylic acid to control HHC36 release for eradicating bacteria in IASO. Colony‐forming unit assay confirmed that Ti‐NTs‐P‐A screws maintained sustainable antibacterial effectiveness, killing over 65% of S. aureus even after multiple bacterial solution replacements. Notably, Ti‐NTs‐P‐A screws exhibit significant pH‐responsive HHC36 release behavior and bactericidal activity, consistent with the phenotype of peptides‐killed bacteria from scanning electron microscopy. Transcriptome sequencing results reveal that Ti‐NTs‐P‐A screws interfered with ribosome formation and disrupted the arginine biosynthesis, which is crucial for bacterial survival in acidic environments. In the non‐infected implant model, the bone‐implant contact ratio of the Ti‐NTs‐P‐A screw is 2.3 times that of the clinically used titanium screw. In an IASO model, Ti‐NTs‐P‐A screws effectively eradicated bacteria within the OLCN, achieving an 80% infection control rate and desirable osteointegration. Collectively, Ti‐NTs‐P‐A screws with pH‐responsive antibacterial properties exhibit great potential for eradicating bacteria and achieving osseointegration in IASO.

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Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Zhou,

Ren,

Zou

et al. 2024

Adv Healthcare Materials

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Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1⁺ Macrophages for Infectious Bone Defect Regeneration

Wu,

Chen,

et al. 2024

ACS Nano

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Release of antibiotics from the materials for postosteomyelitic bone defect filling

Stogov,

Shastov,

Kireeva

et al. 2024

jour

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Introduction The search for materials for bone defect filling that would provide a release of antibiotics in therapeutic levels over a long period is a pressing issue in the treatment of patients with osteomyelitis.The purpose of the work was to compare the kinetics of antibiotic release from materials based on polyurethane polymers for filling post-osteomyelitic bone defects.Materials and methods A comparative in vitro analysis of the kinetic release of cefotaxime, vancomycin, and meropenem from two materials was performed: one was based on polyurethane polymers (RK series) and the other on polymethyl methacrylate (PMMA series). In each series, antibiotics were added to the original materials in three proportions: polymer/ antibiotic — 10:1 (group 1); 10:0.5 (group 2), and 10:0.25 (group 3). The samples were incubated in 10 ml of saline at 37 °C. The incubation solution was changed daily during the first week, and then once a week. Six samples were incubated in each group.Results It was revealed that the volume of eluted cefotaxime in the PMMA series was higher than in the RK series for all antibiotic concentrations. In turn, for vancomycin and meropenem, it was observed only for group 1 samples. For groups 0.5 and 0.25, a larger volume of released antibiotics was noted in the RK series than in the PMMA series. It was found that in the RK series, the release of vancomycin and cefotaxime in an effective (therapeutic) concentration was more prolonged. In the RK series, there was prolonged release of effective concentrations but in a smaller volume of released antibiotic than in the PMMA series.Discussion Each material showed its own antibiotic elution profile and each of them may have its own indications. The RK-based material has advantages in terms of the duration of antibiotic elution in therapeutic doses.Conclusion The release of the studied antibiotics in effective concentrations from the material based on polyurethane polymers is longer than from the PMMA-based material.

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Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

Cited by 3 publications

References 62 publications

Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1⁺ Macrophages for Infectious Bone Defect Regeneration

Release of antibiotics from the materials for postosteomyelitic bone defect filling

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Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

Cited by 3 publications

References 62 publications

Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Efficacy of pH‐Responsive Surface Functionalized Titanium Screws in Treating Implant‐associated S. aureus Osteomyelitis with Biofilms Formation

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1+ Macrophages for Infectious Bone Defect Regeneration

Release of antibiotics from the materials for postosteomyelitic bone defect filling

Contact Info

Product

Resources

About

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1⁺ Macrophages for Infectious Bone Defect Regeneration