Initial therapy of primary hypertension

Jennings, Garry; Sudhir, Krishnankutty

doi:10.5694/j.1326-5377.1990.tb125150.x

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…Until now there has been no convincing evidence to show that combinations of more than one dietary antihypertensive strategy are of greater benefit than a single dietary strategy (Jennings & Sudhir 1990). However, our observation that dietary fish oil enhanced the antihypertensive effect of sodium restriction suggests that there may be an interaction between fish oil and dietary sodium intake, as seen in hypertensive rats (Howe et al 1989(Howe et al , 1990.…”

Section: Discussionmentioning

confidence: 86%

Effects of Dietary Sodium Restriction and Fish Oil Supplements on Blood Pressure in the Elderly

Cobiac

Nestel

Wing

et al. 1991

Clin Exp Pharma Physio

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1. The effects on blood pressure of dietary fish oil, sodium restriction and a combination of both strategies were examined in a short-term dietary intervention study of 50 healthy elderly subjects (average age 67 years) with mean initial systolic and diastolic blood pressures of 133 and 77 mmHg, respectively. 2. Subjects were allocated to one of four treatment groups: fish oil with normal sodium, fish oil with low sodium, sunflower oil with normal sodium and sunflower oil with low sodium for 4 weeks. They then crossed over to the alternative sodium treatment for a further 4 weeks whilst remaining on the same oil. 3. The combination of fish oil supplementation with dietary sodium restriction caused significant reductions of blood pressure in the first 4 weeks: systolic blood pressure (SBP) fell by 8.9 mmHg, mean arterial pressure (MAP) by 7.4 mmHg and diastolic blood pressure (DBP) by 6.0 mmHg. 4. Fish oil enhanced the effect of sodium restriction on blood pressure. In the crossover protocol, a change in sodium excretion of 92 mmol/day was accompanied by changes of 6.4, 3.3 and 2.2 mmHg for SBP, MAP and DBP, respectively, in the subjects taking fish oil. However in those taking sunflower oil, blood pressure did not change significantly. 5. The results indicate beneficial interactive effect of dietary fish oil and sodium intake on blood pressure.

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Section: Discussionmentioning

confidence: 86%

Effects of Dietary Sodium Restriction and Fish Oil Supplements on Blood Pressure in the Elderly

Cobiac

Nestel

Wing

et al. 1991

Clin Exp Pharma Physio

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show abstract

“…Some started drug therapy at a diastolic even below 90 mmHg, clearly levels that may not even be considered abnormal in most of the world. When we use drugs, the majority in the United States and elsewhere continue to prescribe high doses of diuretics and beta blockers, which, as shown in a recent study from Australia clearly, worsen other cardiovascular risks while lowering the blood pressure [9] (Table 1). Furthermore, drugs that have outlived their usefulness, such as alpha-methyldopa, still are widely used.…”

mentioning

confidence: 88%

New approaches to the treatment of hypertension

Kaplan

1991

Cardiovasc Drug Ther

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In the past, therapy of hypertension has not provided protection against coronary heart disease. The possible reasons are multiple and likely will never be fully ascertained. Nonetheless, numerous changes in therapy can be made that should reduce coronary risk. These include more careful monitoring of the blood pressure with particular care for control of high levels during the early morning hours; attention to all alterable risk factors with care to avoid worsening of other risks with antihypertensive drugs; adroit use of nondrug therapies; and, when drugs are used, the pressure should be lowered slowly and only to a level that avoids coronary hypoperfusion.

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“…Jennings & Sudhir (1990) publicaram experimentos, nos quais verificaram hiperatividade adrenérgica em alguns hipertensos e nos estágios precoces da HAS. Com a utilização de exercícios físicos regulares de intensidade moderada, por 40 minutos, três vezes por semana, puderam constatar queda da PA, de 10 a 15mmHg, nos indivíduos sedentários, normo ou hipertensos 9 . Cléroux et al (1992), ao avaliarem os efeitos decorrentes do exercício de membros inferiores na hemodinâmica sistêmica, regional e nos níveis de catecolaminas plasmáticas, evidenciaram que os efeitos anti-hipertensivos do pós-exercício, em hipertensos, estariam correlacionados a importante e significante queda na RP e, também, a redução, sustentada na resistência vascular regional e nos níveis plasmáticos de catecolaminas, que não foram evidenciados no grupo controle de normotensos 13 .…”

Section: Exercícios Físicos E Redução Da Pressão Arterial Em Hipertensosunclassified

“…Dentre essas medidas, vem-se destacando a prática regular de exercícios físicos, componente importante na melhoria da qualidade de vida. Estudos constataram menor morbidade e mortalidade, por doenças do sistema cardiovascular, em indivíduos treinados fisicamente, com benefícios evidentes no subgrupo de hipertensos 9,10 .…”

Section: Introductionunclassified

Os efeitos da atividade física na prevenção da hipertensão

Júnior¹,

Martins²,

Dantas

1999

Rev Bras Med Esporte

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De acordo com o Segundo Consenso Brasileiro para o Tratamento da Hipertensão Arterial (1994), cerca de 14 milhões de brasileiros são hipertensos, sendo 15% desse total adultos em idade economicamente ativa, aumentando consideravelmente os custos sociais por invalidez e absenteísmo ao trabalho. Segundo o quinto relato do Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (1993), mais de 50 milhões de norte-americanos podem ser rotulados como hipertensos, o que afeta cerca de 18% da população de adultos brancos e 35% da de adultos negros. A hipertensão arterial sistêmica, nos países desenvolvidos, constitui o terceiro fator de risco para desordens do aparelho cardiovascular, sendo precedida da dislipidemia e do tabagismo. Grande ênfase tem-se dado às medidas não farmacológicas de mudanças dos hábitos de vida para prevenção e controle dos níveis tensoriais elevados, que devem ser implementadas para todos os hipertensos, mesmo aqueles em uso de droga. Dentre essas medidas, vem-se destacando a prática regular de exercícios físicos, componente importante na melhoria da qualidade de vida. Este artigo de revisão consiste em esclarecer o leitor, dentro de um contexto que envolve as vertentes relacionadas à influência do exercício físico aeróbico no sistema cardiovascular e no comportamento da pressão arterial, para os aspectos específicos da prescrição da reabilitação cardiovascular de hipertensos adultos, com o estabelecimento de carga de trabalho adequada.

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Initial therapy of primary hypertension

Cited by 7 publications

References 64 publications

Effects of Dietary Sodium Restriction and Fish Oil Supplements on Blood Pressure in the Elderly

Effects of Dietary Sodium Restriction and Fish Oil Supplements on Blood Pressure in the Elderly

New approaches to the treatment of hypertension

Os efeitos da atividade física na prevenção da hipertensão

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