Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Decandia, Gianfranco; Palumbo, Fabio; Treglia, Annalisa; Armenise, Vincenza; Favia, Pietro; Baruzzi, Federico; Unger, Katrin; Perrotta, Alberto; Coclite, Anna Maria

doi:10.3390/pharmaceutics12030213

Cited by 11 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The low substrate temperature of iCVD is also compatible with substrates that are unable to withstand significant heating. As a result, iCVD layers have been deposited directly on top of reservoir layers of drug molecules without degrading the drug (Decandia et al, 2020 ).…”

Section: Icvd Polymerizationmentioning

confidence: 99%

“…Fourier transform infrared spectroscopy (FTIR) is widely used for quantifying iCVD copolymer composition. Figure 3A displays the FTIR spectra for a series of copolymers grown from the monomers methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) (Decandia et al, 2020 ). The most intense peak in Figure 3A , as well as in the FTIR spectra of many iCVD films, is the stretching mode of the carbonyl group (C=O).…”

Section: Icvd Polymerizationmentioning

confidence: 99%

“…(C) Percentage of gentamicin released with time. Reprinted with permission from Decandia et al ( 2020 ).…”

Section: Icvd Polymerizationmentioning

confidence: 99%

“…By using a low-growth temperature and by avoiding the use of solvent, the iCVD method enables polymers to form directly on fragile substrates without degrading them. Indeed, pharmaceuticals have been demonstrated to retain their efficacy after being encapsulated with iCVD layers (Sayin et al, 2019b ; Decandia et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Gleason

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release.

show abstract

Section: Icvd Polymerizationmentioning

confidence: 99%

Section: Icvd Polymerizationmentioning

confidence: 99%

“…(C) Percentage of gentamicin released with time. Reprinted with permission from Decandia et al ( 2020 ).…”

Section: Icvd Polymerizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Gleason

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Among the possible chemical vapor deposition methods, initiated chemical vapor deposition (iCVD) suits the requirements to coat pharmaceutics as it operates without plasma, works under mild pressure (>100 mTorr) and low substrate temperature (20–60 °C) and is, therefore, also suitable for delicate substrates such as tissue paper, pharmaceutics or even ionic liquids [ 4 , 5 , 6 ]. iCVD was invented in 2005 by the group of Karen Gleason at the Massachusetts Institute of Technologies and is a vacuum-based free radical polymerization technique [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate

Unger¹,

Coclite²

2020

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Encapsulation of pharmaceutical powders within thin functional polymer films is a powerful and versatile method to modify drug release properties. Conformal coating over the complete surface of the particle via chemical vapor deposition techniques is a challenging task due to the compromised gas–solid contact. In this study, an initiated chemical vapor deposition reactor was adapted with speakers and vibration of particles was achieved by playing AC/DC’s song “Thunderstruck” to overcome the above-mentioned problem. To show the possibilities of this method, two types of powder of very different particle sizes were chosen, magnesium citrate (3–10 µm, cohesive powder) and aspirin (100–500 µm, good flowability), and coated with poly-ethylene-glycol-di-methacrylate. The release curve of coated magnesium citrate powder was retarded compared to uncoated powder. However, neither changing the thickness coating nor vibrating the powder during the deposition had influence on the release parameters, indicating, that cohesive powders cannot be coated conformally. The release of coated aspirin was as well retarded as compared to uncoated aspirin, especially in the case of the powder that vibrated during deposition. We attribute the enhancement of the retarded release to the formation of a conformal coating on the aspirin powder.

show abstract

Temporary Tattoo pH Sensor with pH‐Responsive Hydrogel via Initiated Chemical Vapor Deposition

Unger

Greco

Coclite

2021

Adv Materials Technologies

Self Cite

View full text Add to dashboard Cite

In the expanding field of physiological pH skin sensors, thin temporary tattoo‐based devices have gained attention because of ultra‐conformal adhesion while providing excellent water vapor transmission. Here, a pH sensor tattoo made of temporary tattoo paper, screen‐printed poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate electrodes, and pH‐responsive hydrogel deposited via initiated chemical vapor deposition, is proposed. The tattoo sensor is easily transferred on skin, maintaining full functionality, and shows excellent conformability to topographical features of epidermis. The investigation of the morphology of all layers within the sensor verifies full control of the desired width of electrodes, thickness of hydrogel, and deposition shielded areas. The hydrogel layer exhibits a reversible pH‐responsive swelling of 24.7 ± 0.3% to 38 ± 1%, with respect to the dry state, at pH 4 to pH 6, respectively. Impedance spectroscopy identifies the phase shift at 10 and 1000 Hz as an excellent pH‐related property of the sensor, which can be only ascribed to the presence of the hydrogel. The sensors ability to be operated with non‐sophisticated read‐out hardware and software is also demonstrated.

show abstract

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery

Cited by 11 publications

References 29 publications

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers

Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate

Temporary Tattoo pH Sensor with pH‐Responsive Hydrogel via Initiated Chemical Vapor Deposition

Contact Info

Product

Resources

About