Initiating a National Mammographic Screening Program: The Kuwait Experience Training With a US Cancer Center

Mango, Victoria L.; Al-Khawari, Hanaa; Dershaw, D. David; Ashkanani, Mohammad; Pennisi, Brenda; Turner, P.; Thornton, Cynthia; Morris, Elizabeth A.

doi:10.1016/j.jacr.2018.07.025

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…In our previous 2-year report analysis the recall rate was 14.7% with a PPV1 of 8.2% and PPV3 of 37.1%, and the detection rate was 10.7 invasive cancers per 1000 women screened. 6 In our current study the recall rate fluctuated between 11.9% and 16.5% (mean of 14.3%) which is in the same range as the previous study. 6 In addition, the PPV range for a positive mammogram referred for biopsy was 33–55% and of a positive mammogram among all abnormal mammography cases that required additional imaging was 5–12%.…”

Section: Discussionsupporting

confidence: 81%

“… 6 In our current study the recall rate fluctuated between 11.9% and 16.5% (mean of 14.3%) which is in the same range as the previous study. 6 In addition, the PPV range for a positive mammogram referred for biopsy was 33–55% and of a positive mammogram among all abnormal mammography cases that required additional imaging was 5–12%. The performance benchmarks for mammography among American Radiologists were lower than our results, including a 9.8% recall, 4.8%, PPV1 and 33.8% PPV3.…”

Section: Discussionsupporting

confidence: 81%

“…Their first investigation was reported in 2019. 6 The goal of the present study is to report the outcomes of asymptomatic Kuwaiti women who have undergone screening mammography for the 5-year period 2014–2019.…”

Section: Introductionmentioning

confidence: 99%

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Kuwait National Mammography Screening Program: outcomes of 5 years of screening in Kuwaiti women

et al. 2021

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BACKGROUND: Breast cancer is the most common malignancy among women in Kuwait, representing 39.8% of all female cancer cases. OBJECTIVES: Report the data of the Kuwait National Mammography Screening Program (KNMSP) for a 5-year period. DESIGN: Prospective data collection. SETTING: Population-based screening. SUBJECTS AND METHODS: We included mammography screens done for Kuwaiti women (age 40 years and older) who attended the KNMSP from 2014 to 2019 to screen for breast cancer. A full-field digital mammography system was used to acquire the mammographic images in craniocaudal and mediolateral oblique projections. Independent double-blind reading of the mammograms was performed by two radiologists. MAIN OUTCOME MEASURE: Early detection of breast cancer. SAMPLE SIZE: 14 773 asymptomatic women met inclusion criteria (mean [SD] age, 51.8 (8.2). RESULTS: Lesions were detected in 551 women (3.7%). These included 233 malignant lesions (233/551, 42.3%), 57 high-risk lesions (10.3%) and 261 benign lesions (47.4%). The participation rate was 7.8% of the target population of women 40–69 years of age. The majority of breast cancer cases were reported in the age group 45–49 years (23.2%). The KNMSP study recall rate for 5 consecutive years was in a range of 11.9–16.5% (mean, 14.3%). The detection rate of ductal/lobular carcinoma in situ and invasive breast cancer were 2.5 and 13.6 per 1000 screened women, respectively. Invasive ductal carcinoma was the most common type. Only 4314 women followed up within 12–15 months of the first mammography for a retention rate of 29.2%. CONCLUSIONS: Screening mammography improves early detection of breast cancer in women older than 40 years but poor participation is a limitation. We are aiming to increase the participation rate to 70% of the population. LIMITATIONS: Lack of participation by women. CONFLICT OF INTEREST: None.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

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Kuwait National Mammography Screening Program: outcomes of 5 years of screening in Kuwaiti women

et al. 2021

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“…It is located in 17q23.2, which is a region that has been found to be amplified in breast carcinomas and contains several oncogenes [ 21 ]. This miRNA was found up-regulated in ductal carcinomas in situ (DCIS) compared to non-malignant breast tissues [ 21 ], in several cancers, including BCa [ 17 , 19 , 22 , 23 ] and in the circulation of BCa patients compared to healthy donors [ 21 , 22 , 23 , 24 ]. Moreover, it was found up-regulated in plasma from BCa patients with Her2 and Luminal B subtypes, which proposes a link between hsa-miR-21-5p and the Her2 receptor [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

MiR-106b-5p: A Master Regulator of Potential Biomarkers for Breast Cancer Aggressiveness and Prognosis

Farré

Duca

Massillo

et al. 2021

IJMS

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Breast cancer (BCa) is the leading cause of death by cancer in women worldwide. This disease is mainly stratified in four subtypes according to the presence of specific receptors, which is important for BCa aggressiveness, progression and prognosis. MicroRNAs (miRNAs) are small non-coding RNAs that have the capability to modulate several genes. Our aim was to identify a miRNA signature deregulated in preclinical and clinical BCa models for potential biomarker discovery that would be useful for BCa diagnosis and/or prognosis. We identified hsa-miR-21-5p and miR-106b-5p as up-regulated and hsa-miR-205-5p and miR-143-3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues. We established 51 shared target genes between hsa-miR-21-5p and miR-106b-5p, which negatively correlated with the miRNA expression. Furthermore, we assessed the pathways in which these genes were involved and selected 12 that were associated with cancer and metabolism. Additionally, GAB1, GNG12, HBP1, MEF2A, PAFAH1B1, PPP1R3B, RPS6KA3 and SESN1 were downregulated in BCa compared to NAT. Interestingly, hsa-miR-106b-5p was up-regulated, while GAB1, GNG12, HBP1 and SESN1 were downregulated in aggressive subtypes. Finally, patients with high levels of hsa-miR-106b-5 and low levels of the abovementioned genes had worse relapse free survival and worse overall survival, except for GAB1.

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“…In addition, they are more capable of affording mammograms, which detect many malignancies that would otherwise remain undetected till a later stage [19]. High-income countries are more likely to offer population-based mammography screening programs [20][21][22][23][24][25][26][27][28][29][30][31][32][33] (Figure 3) and have more resources in terms of qualified physicians and mammogram units per capita (Figure 1), which contributes to higher breast cancer incidence through the increased screening. However, high-income countries such as Kuwait, Bahrain, Qatar, Oman, and Saudi Arabia have much lower incidence rates as compared to low-and lowmiddle-income countries (LMICs) such as Jordan, Syrian Arab Republic, Lebanon, Iraq, and Gaza Strip and West Bank.…”

Section: Affluence and Breast Cancer Incidencementioning

confidence: 99%

Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programmes, and Risk-based Screening Initiatives

Lim¹,

Lim²,

Ho³

et al. 2022

Preprint

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Close to half (45.4%) of 2.3 million breast cancers (BC) diagnosed in 2020 were from Asia. While the burden of breast cancer has been examined on the level of broad geographic regions, literature on more in-depth coverage of the individual countries and subregions of the Asian continent is lacking. This review examines the breast cancer burden in 47 Asian countries. Breast cancer screening guidelines and risk-based screening initiatives are discussed.

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Initiating a National Mammographic Screening Program: The Kuwait Experience Training With a US Cancer Center

Cited by 6 publications

References 10 publications

Kuwait National Mammography Screening Program: outcomes of 5 years of screening in Kuwaiti women

Kuwait National Mammography Screening Program: outcomes of 5 years of screening in Kuwaiti women

MiR-106b-5p: A Master Regulator of Potential Biomarkers for Breast Cancer Aggressiveness and Prognosis

Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programmes, and Risk-based Screening Initiatives

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