Initiating newborn screening for metabolic disorders in Pakistan: A qualitative study of the early challenges and opportunities

Wasim, Muhammad; Khan, Haq Nawaz; Ayesha, Hina; Awan, Fazli Rabbi

doi:10.1016/j.rare.2023.100011

Rare

2023

DOI: 10.1016/j.rare.2023.100011

|View full text |Cite

Initiating newborn screening for metabolic disorders in Pakistan: A qualitative study of the early challenges and opportunities

Muhammad Wasim,

Haq Nawaz Khan,

Hina Ayesha

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Types of Inherited Hemoglobin Disorders among the Patients Attending a Tertiary Care Hospital

Anwar,

Arzoo,

Riaz

et al. 2024

PJHS-Lahore

View full text Add to dashboard Cite

The genetic conditions known as hemoglobinopathies, which include thalassemia impact the synthesis and structure of Hemoglobin, the red blood cell protein that carries oxygen. Objectives: To investigate the prevalence of different types of thalassemia associated with age, gender and Hematological parameters. Methods: The total number of participants was n=139. The cross-sectional study was conducted at Rai Medical College Sargodha. The study was conducted for six months, from July 2023 to Dec 2023. Biochemical parameters investigated such as Hemoglobin, mean corpuscular hemoglobin MCH, reticulocyte and ferritin were done in the Hematology lab. Collected data were analyzed by SPSS version 25.0. Results: The gender distribution among the participants included male 50.3% and female 49.6%. The mean age of the patients was approximately 34.8 years. This study of 139 participants found Hb-E Beta Thalassemia (25.4%) to be the most common type, especially among those with a history of cousin marriage. Severe forms like Hb-E Beta Thalassemia and Beta Thalassemia Major had low hemoglobin and MCH levels, indicating severe anemia, while milder forms showed near-normal levels. In mean corpuscular Hemoglobin E Beta Thalassemia (29.7 ± 4.1), p=0.001, mean corpuscular Hemoglobin A levels are considerably lower than Beta Thalassemia Trait. There was no association with age and gender, p>0.005. Conclusions: It was concluded that our investigation offered important insights into the biochemical profiles linked to various thalassemia types, even though it did not identify any appreciable variations in thalassemia prevalence by age or gender.

show abstract

Types of Inherited Hemoglobin Disorders among the Patients Attending a Tertiary Care Hospital

Anwar,

Arzoo,

Riaz

et al. 2024

PJHS-Lahore

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Initiating newborn screening for metabolic disorders in Pakistan: A qualitative study of the early challenges and opportunities

Cited by 1 publication

References 17 publications

Types of Inherited Hemoglobin Disorders among the Patients Attending a Tertiary Care Hospital

Types of Inherited Hemoglobin Disorders among the Patients Attending a Tertiary Care Hospital

Contact Info

Product

Resources

About