2018
DOI: 10.1016/j.cell.2017.11.036
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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

Abstract: SummaryB cells constitute an essential line of defense from pathogenic infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although this process is known to be regulated by follicular helper T (TfH) cells, the mechanism by which B cells initially seed germinal center reactions remains elusive. We found that NKT cells, a population of innate-like T lymphocytes, are critical for the induction of B cell immunity upon viral infection. The positioning of NKT cell… Show more

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Cited by 150 publications
(153 citation statements)
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“…Next, we investigated whether CD11c + cells are involved in CD1d‐dependent presentation of intestinal lipids to iNKT cells. We took advantage of a newly generated CD1d fl/fl mouse (Gaya et al , ) that we crossed with CD11c‐Cre mice to generate mice deficient in CD1d on CD11c + cells (CD1d fl/fl CD11c Cre strain; Appendix Fig S1B–G). To characterize DCs, we identified them as CD11c + MHC‐II + cells and segregated the DC/macrophage populations based on the expression of CD103 and CD11b as previously described (Loschko et al , ).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Next, we investigated whether CD11c + cells are involved in CD1d‐dependent presentation of intestinal lipids to iNKT cells. We took advantage of a newly generated CD1d fl/fl mouse (Gaya et al , ) that we crossed with CD11c‐Cre mice to generate mice deficient in CD1d on CD11c + cells (CD1d fl/fl CD11c Cre strain; Appendix Fig S1B–G). To characterize DCs, we identified them as CD11c + MHC‐II + cells and segregated the DC/macrophage populations based on the expression of CD103 and CD11b as previously described (Loschko et al , ).…”
Section: Resultsmentioning
confidence: 99%
“…CD1d fl/fl mice were generated by multi‐site Red/ET recombination in an ES line of B6 origin as reported (Gaya et al , ). Briefly, exon 3 of the Cd1d1 gene was loxP‐flanked and a PGK/neomycin cassette was introduced for in vitro selection of the recombined ES cells.…”
Section: Methodsmentioning
confidence: 99%
“…Like conventional αβ T cells, unconventional T cells express antigen-specific TCRs although their TCR repertoire is more restricted and composed of larger clonal families. The combination of this broad range of effector functions with the ability to rapidly respond to stimulation enable unconventional T cells to influence T cell and B cell responses early during immune responses (4,5). In addition, the unique TCR repertoire from unconventional T cells enables the recognition of antigens with unique biochemical characteristics such as microbial lipids, phosphoantigens, and metabolites presented by nonclassical major histocompatibility complex (MHC) molecules, which is in contrast to the peptide-restricted TCRs of conventional αβ T cells (1)(2)(3).…”
Section: Introductionmentioning
confidence: 99%
“…Classical natural killer T (NKT) cells express a highly biased T‐cell receptor (TCR) repertoire and serve as a bridge between the innate and adaptive immune systems . The semi‐invariant human NKT cell TCR comprises a fixed TRAV10/TRAJ18 gene‐encoded α‐chain with a canonical CDR3α loop and a restricted TRBV25 gene‐encoded β‐chain, which together enable the recognition of glycolipids presented in the context of CD1d .…”
Section: Introductionmentioning
confidence: 99%