Initiation of migrating myoelectric complexes in human subjects: role of duodenal acidification and plasma motilin

Daniel, E. E.; Fox, J. E. T.; Collins, S. M.; Lewis, T. A.; Meghji, Mohamed M.; Track, Norman S.

doi:10.1139/y81-029

Cited by 16 publications

(4 citation statements)

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“…Measuring motilin response to a stimulus while ignoring its basal variation generates results of questionable significance, as we observed earlier in animals (22). Suboptimal experimental protocols used in earlier studies (6)(7)(8)(9)(10)(11) may possibly explain the controversial data then obtained. The postprandial increase of motilin we documented in man is not present in the dog, in which the ingestion of a meal abolishes motilin cyclical increases typical of the interdigestive period (3).…”

Section: Discussionmentioning

confidence: 92%

“…First, cyclic elevations in circulating motilin are present during the fasting state, coinciding with the phase 111 period of the MMC, and are abolished after feeding (3). Second, administration of exogenous synthetic canine motilin, at doses mimicking physiologic increases in the blood, in-(6), You et al (7), and Vantrappen et al (8) reported that the variations in endogenous circulating motilin were associated with the MMCs in man as in dog; however, these data could not be corroborated by Lux et al (9), Rees et al (lo), or Daniel et al (11).…”

Section: Introductionmentioning

confidence: 99%

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Plasma Motilin Variation During the Interdigestive and Digestive States in Man

Boivin

Raymond

Riberdy

et al. 1990

Neurogastroenterology Motil

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To evaluate the role of motilin in human physiology, we measured plasma motilin during the inter digestive and digestive states while recording antroduodenal contractile activity. In 24 healthy fasting subjects, 51 migrating periods of phase III activity were recognized, 42 of them started from the antral region and nine from the duodenum. A definite association was noted between circulating motilin and the gastric migrating motor complex. Significant peak elevations in plasma motilin were associated with phase Ills initiated from the antrum, but not with those originating from the duodenum. Exogenous synthetic motilin, when administered in supraphysiologic amounts, induced premature periods of front activity in fasting subjects. A test meal administered 30 minutes after a front of antral activity induced a significant release of motilin. Elevated plasma motilin levels were detected postprandially for a period of 30 minutes. Postprandial motilin increases were comparable in amplitude to the cyclic peak increases observed during the fasting period. Our study brings support for the argument that the contractile activity of the fasting stomach is regulated by circulating motilin in man, as it is in animals. The documented postprandial release of motilin is, however, unique to man and suggests that motilin could also be active during the digestive period in this species.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Plasma Motilin Variation During the Interdigestive and Digestive States in Man

Boivin

Raymond

Riberdy

et al. 1990

Neurogastroenterology Motil

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“…It has been suggested that circulating motilin levels may rise as a result of intestinal muscle contraction expressing the peptide into the circulation during the m.m.c. (Daniel, Fox, Collins, Lewis, Meghji & Track, 1980;Sarna, Chey, Condon, Dodds, Myers & Chang, 1983). This proposed mechanism is difficult to accept in view of the observations of: peak motilin levels in dogs before, during or after m.m.c.…”

Section: Discussionmentioning

confidence: 97%

Motilin and Migrating Myoelectric Complexes in the Pig and the Dog

1984

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Associations between migrating myoelectric complexes (m.m.c.s) and peak plasma motilin concentrations were confirmed in the dog fasted 18 h and shown not to be present in pigs fasted 3-4 h. Infusions of both natural porcine and synthetic 13-Nle-motilin failed to induce m.m.c.s in the pig. It was confirmed that motilin infusions stimulated the premature appearance of m.m.c.s in the dog whether motilin remained within, or exceeded, its normal plasma values. Immunoneutralization by intravenous administration of rabbit antimotilin serum was without effect on naturally occurring m.m.c.s in the dog and the pig. In the dog, antimotilin serum blocked production of m.m.c.s by exogenous motilin for 7-10 d post-immunoneutralization. It is suggested that there are both: (i) species differences in associations of m.m.c.s and plasma motilin concentration, and (ii) an independence of m.m.c.s from plasma motilin even in the dog in which normally exogenous motilin can produce m.m.c.s.

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“…In humans, controversy exists as to the role of motilin. Ouyang and Cohen (26) report that motilin concentrations are closely associated with the onset of phase 3 interdigestive myoelectric activity, while Daniel et al (33) report that plasma motilin concentrations do not correlate well with the phases of myoelectric activity. Although we did not correlate motilin samples with propulsive phase 3 myoelectric activity, we observed insignificant changes in motilin concentrations following a CF or HOF meal.…”

Section: Resultsmentioning

confidence: 99%

Hyperosmolal Formula in Neonatal Piglets

Szabo,

Rayford,

Uthman

et al. 1990

J. pediatr. gastroenterol. nutr.

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SummaryIngestion of hyperosmolal formula (HOF) by neonatal piglets has been shown to cause significant time‐dependent reduction in phase 3 myoclectric activity, which persists in the terminal ileum. To determine whether a single hyperosmolal meal leads to elevated concentrations of gastrointestinal (GI) hormones that inhibit intestinal motility and/or promote bacterial proliferation and disruption of intestinal mucosa, we studied 20 healthy neonatal piglets following feeding with an increased HOF (872 ± 32 mOsmol/kg, n = 10) and commercial pig milk formula (481 ± 41 mOsmol/kg, n = 10). Gastrin, secretin, cholecystokinin, and motilin concentrations were determined by radioimmunoassay during fasting and postprandial periods (15, 30, 45, 120, 180, and 240 min). Gastrin concentrations were significantly increased at 15 and 30 min following a hyperosmolal meal (p < 0.01), but there were no statistical differences in GI hormone concentrations between groups. These transient elevations of gastrin concentrations are associated with significant postprandial reductions in phase 3 small intestinal myoelectric activity (SIMEA) that we have observed. Aerobic bacterial titers were not significantly different between proximal and distal small intestinal segments or between experimental groups, and anaerobic bacteria were seldom recovered. Thus, SIMEA was not sufficiently altered to produce significant bacterial proliferation. Small intestinal histology, assessed by light microscopy, showed normal proximal and distal small intestinal mucosa in 8 of 10 piglets from each group. Therefore, orogastric instillation of a single hyperosmolal feed does not result in intestinal mucosal damage. Further studies are warranted to determine the effects of hyperosmolal feeds when additional risk factors exist in the neonate.

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Initiation of migrating myoelectric complexes in human subjects: role of duodenal acidification and plasma motilin

Cited by 16 publications

References 0 publications

Plasma Motilin Variation During the Interdigestive and Digestive States in Man

Plasma Motilin Variation During the Interdigestive and Digestive States in Man

Motilin and Migrating Myoelectric Complexes in the Pig and the Dog

Hyperosmolal Formula in Neonatal Piglets

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