2007
DOI: 10.1016/j.immuni.2007.04.007
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Initiation of Plasma-Cell Differentiation Is Independent of the Transcription Factor Blimp-1

Abstract: Blimp-1 is considered an essential regulator of the terminal differentiation of B cells into antibody-secreting plasma cells. We show here that Rag1-/- mice reconstituted with fetal liver cells homozygous for a DNA-binding-deficient mutant of Prdm1 (the gene encoding Blimp-1) lack a defined plasma-cell compartment, yet show detectable amounts of all immunoglobulin isotypes. In vitro analysis revealed that Blimp-1 is not required for the initiation of antibody secretion but is essential for subsequent high immu… Show more

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Cited by 226 publications
(306 citation statements)
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References 43 publications
(87 reference statements)
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“…Our previous results indicated that the inactivation of PAX5 in B cells results in the loss of BCL6 expression and induction of plasma cell differentiation after losing B-cell characteristics [4]. In support of the idea that the loss of the B-cell phenotype is the initial step in the induction of plasmacytic differentiation, a population of B cells that have lost their B-cell phenotype, but not yet started to express PRDM1, has been identified [3].…”
Section: Discussionmentioning
confidence: 67%
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“…Our previous results indicated that the inactivation of PAX5 in B cells results in the loss of BCL6 expression and induction of plasma cell differentiation after losing B-cell characteristics [4]. In support of the idea that the loss of the B-cell phenotype is the initial step in the induction of plasmacytic differentiation, a population of B cells that have lost their B-cell phenotype, but not yet started to express PRDM1, has been identified [3].…”
Section: Discussionmentioning
confidence: 67%
“…5) in which both Pax5 and Bcl6 are essential in the maintenance of GC B-cell phenotype. Given that the expression of Pax5 is downregulated before the induction of Blimp-1 [3], the apparent need of Pax5 for Bcl6 expression [4] and the potency of Bcl6 to suppress Blimp-1, it is likely that loss of both Bcl6 and Pax5 expression is needed to initiate plasma cell differentiation.…”
Section: Discussionmentioning
confidence: 99%
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“…Eventually, PAX5 is replaced by BLIMP1, which initiates plasma cell differentiation (14). The abolition of PAX5-mediated repression was thought to be the first event to initiate plasma cell differentiation (16); however, the mechanism is still unknown. In this study, we demonstrated that PAX5 was phosphorylated by ERK1/2 in vitro and in vivo at serines 189 and 283.…”
mentioning
confidence: 99%