Initiation of type 2 immunity at barrier surfaces

McDaniel, Margaret M.; Lara, Heber I; Moltke, Jakob von

doi:10.1016/j.mucimm.2022.11.002

Cited by 6 publications

(2 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EoE is characterized by a specific cytokine secretion pattern that determines it as a type 2 inflammatory disease [18,19]. In healthy conditions, T helper 2 (Th2) cells are primarily important in defense against helminth infections and exposure to venoms [20], but in atopic individuals, they are also involved in different types of allergic diseases including asthma, atopic dermatitis, allergic rhinitis, and food allergies [21]. Thus, a Th2 response is induced in EoE as a particular form of non-IgE-mediated food allergy, and typically associated with increased expression of interleukin (IL)-4, IL-5, IL-13, and eotaxins [22].…”

Section: Immunological Aspects Of Eoementioning

confidence: 99%

Fibrous Remodeling in Eosinophilic Esophagitis: Clinical Facts and Pathophysiological Uncertainties

Arias-González,

Rodríguez-Alcolado,

Laserna-Mendieta

et al. 2024

IJMS

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is a chronic, progressive, type 2 inflammatory disease with increasing global prevalence. An eosinophil-predominant inflammation that permeates the epithelium and deeper esophageal layers characterizes the disease. Several cytokines, mainly derived from inflammatory T-helper 2 (Th2) cells and epithelial cells, are involved in perpetuating inflammatory responses by increasing surface permeability and promoting tissue remodeling characterized by epithelial–mesenchymal transition (EMT) and collagen deposition. This leads to esophageal strictures and narrow caliber esophagi, which are proportional a patient’s age and untreated disease length. Pathophysiological mechanisms leading to EoE have been described in recent years, and transforming growth factor beta (TGF)-beta have been involved in fibrotic phenomena in EoE. However, evidence on the dependence of these phenomena on TGF-beta is scarce and contradictory. This review provides state-of-the art knowledge on intimate mechanisms of esophageal fibrosis in EoE and its clinical consequences.

show abstract

Section: Immunological Aspects Of Eoementioning

confidence: 99%

Fibrous Remodeling in Eosinophilic Esophagitis: Clinical Facts and Pathophysiological Uncertainties

Arias-González,

Rodríguez-Alcolado,

Laserna-Mendieta

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Most attention in recent years has been given to the pathways of type 2 induction and its regulation in immunological disorders ( Gause et al, 2020 ; Hammad and Lambrecht, 2015 ; McDaniel et al, 2023 ). In brief, the type 2 response depends on innate cell sensing of infection, invasion, or actual tissue damage, such as that resulting from large multicellular parasites trafficking through tissues and releasing degradative enzymes and other excretory/secretory products that cause cellular damage.…”

Section: Introductionmentioning

confidence: 99%