Initiator-free synthesis of molecularly imprinted polymers by polymerization of self-initiated monomers

Panagiotopoulou, Maria; Beyazıt, Selim; Nestora, Sofia; Haupt, Karsten; Bui, Bernadette Tse Sum

doi:10.1016/j.polymer.2015.04.012

Cited by 36 publications

(23 citation statements)

References 43 publications

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“…Actually, MIPs are synthesized by free radical polymerization, generated by the thermal or photo homolysis of a chemical bond on an initiator. The most widely used initiators for MIPs synthesis are benzoyl peroxide (BPO), 2,2-dimethoxy-2-phenylacetophenone (DMPA) and 2-azobis(2-methylpropionitrile) (AIBN) and 2,20-azo-bis(2,4-dimethyl) valeronitrile (ABDV) [17].…”

Section: Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

Wastewater Treatment Using Imprinted Polymeric Adsorbents

Okutucu¹

2020

Waste in Textile and Leather Sectors

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In twenty-first century, numbers of synthetic dyes are used in many industries, for example paper, textile, cosmetic, leather for coloring, vs. The dyeing industries wastes is the most found contaminant to be recognized in wastewater. There are various treatment methods including oxidation processes, biological degradation, membrane filtration and coagulation/flocculation have been studied to treat dyeing wastewater. Unfortunately, these methods are high operational costs, complicated operations and possibility of producing more toxic products. Molecularly imprinted polymers (MIPs) are interesting and alternative polymeric adsorbents that can be applied in wastewater treatment for sample preparation and for the quantification of dyes present in wastewater. Molecular imprinting is a process in which functional and crosslinking monomers are co-polymerized in the presence of the target analyte, the imprint molecule. Initially, the functional monomer forms a complex and, after polymerization, their functional groups are held by the highly crosslinking polymeric structure. Upon leaching of the imprint molecule from the polymer matrix, a polymer with binding sites complementary in size and shape to the imprint molecule is created. MIPs can function under extreme conditions of pH, temperature and complex environment. Also, MIPs present wide recognition due to their stability, ease of production and low-cost potential.

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Section: Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

Wastewater Treatment Using Imprinted Polymeric Adsorbents

Okutucu¹

2020

Waste in Textile and Leather Sectors

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“…In the context of cross‐linked polymer nanoparticles, such as MIPs, self‐initiated polymerization without initiators is possible in some cases, although this method is not compatible with all monomers . To broaden the application of these materials, we propose herein a novel strategy to produce MIPs in aqueous media by a “greener” process, in which molecularly imprinted polymer nanoparticles (MIP‐NPs) are synthesized by enzyme‐mediated free‐radical polymerization; an immobilized horseradish peroxidase (HRP) is used to catalyze the formation of free radicals (Figure A).…”

Section: Figurementioning

confidence: 99%

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

et al. 2017

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An enzyme‐mediated synthetic approach is described for the preparation of molecularly imprinted polymer nanoparticles (MIP‐NPs) in aqueous media. Horseradish peroxidase (HRP) was used to initiate the polymerization of methacrylate or vinyl monomers and cross‐linkers by catalyzing the generation of free radicals. To prevent entrapment of the enzyme in the cross‐linked polymer, and to enable it to be reused, HRP was immobilized on a solid support. MIPs based on 4‐vinylpyridine and 1,4‐bis(acryloyl)piperazine for the recognition of 2,4‐dichlorophenoxyacetic acid (2,4‐D) and salicylic acid were synthesized in an aqueous medium. MIPs for the protein trypsin were also synthesized. MIP nanoparticles with sizes between 50 and 300 nm were obtained with good binding properties, a good imprinting effect, and high selectivity for the target molecule. The reusability of immobilized HRP for MIP synthesis was shown for several batches.

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“…More traditional laboratory-based methods have also been used, such as: gas chromatography (GC) for measurement of anabolic steroids [11] and extraction steroids [12]; liquid chromatography (LC) for measurement of epitestosterone [13], testosterone [13][14][15], or other steroids [16]; capillary electrophoresis (EC) linked with mass spectrometry (MS) for testosterone [17], epitestosterone [17], urinary steroid hormones [18] and estrogenic endocrine disruptors [19]; diode-array detection (DAD) of steroids [20], progesterone [21] and testosterone [21] in human urine [11,17,[20][21][22][23] or in goat milk [24]. The functional and crosslinking monomers that have been used in molecular imprinting include acrylamide [16], methacrylic acid (MAA) [7][8][9][10][11]13,15,17,20,21,[24][25][26][27][28], trifluoromethacrylic acid (TFMAA) [13], 2-hydroxyethyl methacrylate (HEMA) [9,26], ethylvinylbenzene (EVB) [7], 2-vinylpyridine (2VP) [12], [12,…”

Section: Introductionmentioning

confidence: 99%

Self-assembly Synthesis of Molecularly Imprinted Polymers for the Ultrasensitive Electrochemical Determination of Testosterone

et al. 2020

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Molecularly imprinted polymers (MIPs) can often bind target molecules with high selectivity and specificity. When used as MIPs, conductive polymers may have unique binding capabilities; they often contain aromatic rings and functional groups, which can undergo π-π and hydrogen bonding interactions with similarly structured target (or template) molecules. In this work, an electrochemical method was used to optimize the synthetic self-assembly of poly(aniline-co-metanilic acid) and testosterone, forming testosterone-imprinted electronically conductive polymers (TIECPs) on sensing electrodes. The linear sensing range for testosterone was from 0.1 to 100 pg/mL, and the limit of detection was as low as ~pM. Random urine samples were collected and diluted 1000-fold to measure testosterone concentration using the above TIECP sensors; results were compared with a commercial ARCHITECT ci 8200 system. The testosterone concentrations in the tested samples were in the range of 0.33 ± 0.09 to 9.13 ± 1.33 ng/mL. The mean accuracy of the TIECP-coated sensors was 90.3 ± 7.0%.

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Initiator-free synthesis of molecularly imprinted polymers by polymerization of self-initiated monomers

Cited by 36 publications

References 43 publications

Wastewater Treatment Using Imprinted Polymeric Adsorbents

Wastewater Treatment Using Imprinted Polymeric Adsorbents

Enzyme‐Initiated Free‐Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source

Self-assembly Synthesis of Molecularly Imprinted Polymers for the Ultrasensitive Electrochemical Determination of Testosterone

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