Injectable alginate-based in situ self-healable transparent hydrogel as a vitreous substitute with a tamponading function

Choi, Geunho; An, Seoung Hyun; Choi, Jae-Won; Rho, Mee Sook; Park, Woo Chan; Jeong, Woo jin; Cha, Hyung Joon

doi:10.1016/j.biomaterials.2023.122459

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…Although it maintained a relatively consistent transparency of around 87% over time, it possesses a slightly lower transparency compared to natural vitreous and traditional vitreous substitutes. Additionally, the TALPPH hydrogel was effective functionally as a vitreous substitute in preventing retinal detachment and maintaining intraocular pressure without adverse effects such as post-operative cataracts and opacification [ 124 ]. Other compositions of alginate-hyaluronic acid-based hydrogels were also evaluated as potential vitreous replacements, where results showed high biocompatibility, high optical quality of >90% transparency, and similar viscoelastic properties as natural vitreous bodies [ 125 ].…”

Section: Applications Of Hydrogels In Ophthalmologymentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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The interface between material science and ophthalmic medicine is witnessing significant advances with the introduction of biopolymers in medical device fabrication. This review discusses the impact of biopolymers on the development of ophthalmic devices, such as intraocular lenses, stents, and various prosthetics. Biopolymers are emerging as superior alternatives due to their biocompatibility, mechanical robustness, and biodegradability, presenting an advance over traditional materials with respect to patient comfort and environmental considerations. We explore the spectrum of biopolymers used in ophthalmic devices and evaluate their physical properties, compatibility with biological tissues, and clinical performances. Specific applications in oculoplastic and orbital surgeries, hydrogel applications in ocular therapeutics, and polymeric drug delivery systems for a range of ophthalmic conditions were reviewed. We also anticipate future directions and identify challenges in the field, advocating for a collaborative approach between material science and ophthalmic practice to foster innovative, patient-focused treatments. This synthesis aims to reinforce the potential of biopolymers to improve ophthalmic device technology and enhance clinical outcomes.

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Section: Applications Of Hydrogels In Ophthalmologymentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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Application of Silicone in Ophthalmology: A Review

Mladenovic,

Zivic,

Petrovic

et al. 2024

Materials

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This paper reviews the latest trends and applications of silicone in ophthalmology, especially related to intraocular lenses (IOLs). Silicone, or siloxane elastomer, as a synthetic polymer, has excellent biocompatibility, high chemical inertness, and hydrophobicity, enabling wide biomedical applications. The physicochemical properties of silicone are reviewed. A review of methods for mechanical and in vivo characterization of IOLs is presented as a prospective research area, since there are only a few available technologies, even though these properties are vital to ensure medical safety and suitability for clinical use, especially if long-term function is considered. IOLs represent permanent implants to replace the natural lens or for correcting vision, with the first commercial foldable lens made of silicone. Biological aspects of posterior capsular opacification have been reviewed, including the effects of the implanted silicone IOL. However, certain issues with silicone IOLs are still challenging and some conditions can prevent its application in all patients. The latest trends in nanotechnology solutions have been reviewed. Surface modifications of silicone IOLs are an efficient approach to further improve biocompatibility or to enable drug-eluting function. Different surface modifications, including coatings, can provide long-term treatments for various medical conditions or medical diagnoses through the incorporation of sensory functions. It is essential that IOL optical characteristics remain unchanged in case of drug incorporation and the application of nanoparticles can enable it. However, clinical trials related to these advanced technologies are still missing, thus preventing their clinical applications at this moment.

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Injectable alginate-based in situ self-healable transparent hydrogel as a vitreous substitute with a tamponading function

Cited by 2 publications

References 51 publications

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Application of Silicone in Ophthalmology: A Review

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